Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zenon, Konteatis"'
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Figure 1. Synthesis and pharmacokinetic characterization of AG-221. Supplementary Figure 2. Biochemical attributes of AG-221. Supplementary Figure 3. Biochemistry of AG-221 with respect to substrate and cofactor. Supplementary Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1
https://doi.org/10.1158/2159-8290.22531945.v1
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Table 1. Drug metabolism and pharmacokinetic attributes of AG-221. Supplementary Table 2. Selectivity of AG-221 confirmed by testing against a panel of kinases. Supplementary Table 3. Clinical characteristics of patients with IDH2R140Q-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936
https://doi.org/10.1158/2159-8290.22531936
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939
https://doi.org/10.1158/2159-8290.22531939
Autor:
Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, met
Externí odkaz:
https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141
Autor:
Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui, Samuel K. Reznik
Publikováno v:
Journal of medicinal chemistry. 65(6)
Inhibition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4665a566b3b92c2d5c0229953dea0
https://pubmed.ncbi.nlm.nih.gov/35293760
https://pubmed.ncbi.nlm.nih.gov/35293760
Autor:
Zenon, Konteatis, Jeremy, Travins, Stefan, Gross, Katya, Marjon, Amelia, Barnett, Everton, Mandley, Brandon, Nicolay, Raj, Nagaraja, Yue, Chen, Yabo, Sun, Zhixiao, Liu, Jie, Yu, Zhixiong, Ye, Fan, Jiang, Wentao, Wei, Cheng, Fang, Yi, Gao, Peter, Kalev, Marc L, Hyer, Byron, DeLaBarre, Lei, Jin, Anil K, Padyana, Lenny, Dang, Joshua, Murtie, Scott A, Biller, Zhihua, Sui, Kevin M, Marks
Publikováno v:
Journal of medicinal chemistry. 64(8)
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ec9204e0504cb32589dbe975f9a1cd3
https://pubmed.ncbi.nlm.nih.gov/33829783
https://pubmed.ncbi.nlm.nih.gov/33829783
Autor:
Katharine, Yen, Jeremy, Travins, Fang, Wang, Muriel D, David, Erin, Artin, Kimberly, Straley, Anil, Padyana, Stefan, Gross, Byron, DeLaBarre, Erica, Tobin, Yue, Chen, Raj, Nagaraja, Sung, Choe, Lei, Jin, Zenon, Konteatis, Giovanni, Cianchetta, Jeffrey O, Saunders, Francesco G, Salituro, Cyril, Quivoron, Paule, Opolon, Olivia, Bawa, Véronique, Saada, Angelo, Paci, Sophie, Broutin, Olivier A, Bernard, Stéphane, de Botton, Benoît S, Marteyn, Monika, Pilichowska, YingXia, Xu, Cheng, Fang, Fan, Jiang, Wentao, Wei, Shengfang, Jin, Lee, Silverman, Wei, Liu, Hua, Yang, Lenny, Dang, Marion, Dorsch, Virginie, Penard-Lacronique, Scott A, Biller, Shin-San Michael, Su
Publikováno v:
Cancer discovery. 7(5)
AG-221 or enasidenib is a first-in-class selective inhibitor of mutated isocitrate dehydrogenase 2 (IDH2) with early demonstrated clinical efficacy in acute myeloid leukemia as a single agent, yet with persistence of mutant IDH2 clones. Two papers in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d30618427a82a8efe6855ead5edc951
https://pubmed.ncbi.nlm.nih.gov/28461409
https://pubmed.ncbi.nlm.nih.gov/28461409
Publikováno v:
Drug Development Research. 72:130-137
Fragment-based drug design (FBDD) has become an important and successful approach to drug discovery. In this review, we discuss two classes of simulation technologies that we routinely employ as part our of computational FBDD efforts. The first class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136d12228975936aaf035b24bc8fb653
https://doi.org/10.1002/ddr.20409
https://doi.org/10.1002/ddr.20409
Publikováno v:
Journal of Chemical Information and Modeling. 51:52-60
We introduce TICRA (transplant-insert-constrain-relax-assemble), a method for modeling the structure of unknown protein-ligand complexes using the X-ray crystal structures of homologous proteins and ligands with known activity. We present results fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b904e9fe3582307a8728d8cca8b1d49c
https://doi.org/10.1021/ci100256u
https://doi.org/10.1021/ci100256u
Autor:
Steven J. Freedman, Matthew Clark, Jinming Zou, Jeffrey S. Wiseman, Jennifer L. Ludington, George Talbot, Sia Meshkat, Zenon Konteatis
Publikováno v:
Drug Development Research. 70:279-287
The development of small-molecule drugs to counter the threat of bioterrorism will differ from classical drug discovery because it will be impossible to evaluate efficacy in clinical trials for many agents. This difference focuses biodefense on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c08cdc8f5a8ea3d7b680d427268f69
https://doi.org/10.1002/ddr.20305
https://doi.org/10.1002/ddr.20305