Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms.

Autor: Rokad D; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Harischandra DS; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Samidurai M; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA., Chang YT; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA., Luo J; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Lawana V; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Sarkar S; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Palanisamy BN; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Manne S; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Kim D; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Zenitsky G; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA., Jin H; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA., Anantharam V; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA., Willette A; Department of Neurology, Rutgers University, New Brunswick, NJ 07101, USA., Kanthasamy A; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA., Kanthasamy AG; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.; Isakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, 325 Riverbend Road, Athens, GA 30602, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 14; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 14.

Epitranscriptomic reader YTHDF2 regulates SEK1( MAP2K4 )-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.

Autor: Malovic E; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Ealy A; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Miller C; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Jang A; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Hsu PJ; Department of Chemistry, University of Chicago, Chicago, IL, USA., Sarkar S; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Rokad D; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Goeser C; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Hartman AK; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Zhu A; Department of Chemistry, University of Chicago, Chicago, IL, USA., Palanisamy B; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Zenitsky G; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Jin H; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Anantharam V; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Kanthasamy A; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., He C; Department of Chemistry, University of Chicago, Chicago, IL, USA., Kanthasamy AG; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.

Publikováno v: IScience [iScience] 2024 Jul 31; Vol. 27 (9), pp. 110619. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).

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Video recording system for the measurement of eyelid movements during classical conditioning of the eyeblink response in the rabbit

Autor: Bracha, Vlastislav ^*, Nilaweera, W., Zenitsky, G., Irwin, K.

Publikováno v: In Journal of Neuroscience Methods 2003 125(1):173-181

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders.

Autor: Padhi P; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States., Worth C; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States., Zenitsky G; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States., Jin H; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States., Sambamurti K; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States., Anantharam V; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States., Kanthasamy A; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States., Kanthasamy AG; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.; Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2022 Feb 25; Vol. 16, pp. 836605. Date of Electronic Publication: 2022 Feb 25 (Print Publication: 2022).