Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zengyuan Zhang"'
Publikováno v:
Cell Insight, Vol 3, Iss 2, Pp 100150- (2024)
As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. Th
Externí odkaz:
https://doaj.org/article/b5a4952f5af2440aae968b401023b566
Autor:
Zhennan Zhao, Jingya Zhou, Mingxiong Tian, Min Huang, Sheng Liu, Yufeng Xie, Pu Han, Chongzhi Bai, Pengcheng Han, Anqi Zheng, Lutang Fu, Yuanzhu Gao, Qi Peng, Ying Li, Yan Chai, Zengyuan Zhang, Xin Zhao, Hao Song, Jianxun Qi, Qihui Wang, Peiyi Wang, George F. Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F subst
Externí odkaz:
https://doaj.org/article/90e8f270726e4bf38984d7f2e5f9e902
Autor:
Pengcheng Han, Chao Su, Yanfang Zhang, Chongzhi Bai, Anqi Zheng, Chengpeng Qiao, Qing Wang, Sheng Niu, Qian Chen, Yuqin Zhang, Weiwei Li, Hanyi Liao, Jing Li, Zengyuan Zhang, Heecheol Cho, Mengsu Yang, Xiaoyu Rong, Yu Hu, Niu Huang, Jinghua Yan, Qihui Wang, Xin Zhao, George Fu Gao, Jianxun Qi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The SARS-CoV-2 spike (S) protein mediates viral entry by binding of its receptor-binding domain (RBD) to the human angiotensin-converting enzyme 2 (ACE2) receptor and mutations of the S protein may have a great impact on virus transmissibility. Here,
Externí odkaz:
https://doaj.org/article/dc7aa3eaa6504c398a72531979ddf0df
Autor:
Zengyuan Zhang, Yanfang Zhang, Kefang Liu, Yan Li, Qiong Lu, Qingling Wang, Yuqin Zhang, Liang Wang, Hanyi Liao, Anqi Zheng, Sufang Ma, Zheng Fan, Huifang Li, Weijin Huang, Yuhai Bi, Xin Zhao, Qihui Wang, George F. Gao, Haixia Xiao, Zhou Tong, Jianxun Qi, Yeping Sun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angioten
Externí odkaz:
https://doaj.org/article/79fdbab038eb40bfba09615269e6e989
Publikováno v:
Future Generation Computer Systems. 146:260-272
Publikováno v:
IEEE Transactions on Computers. :1-14
Autor:
Chengpeng Qiao, Anqi Zheng, Jing Li, Sheng Niu, Qihui Wang, Yanfang Zhang, Yuqin Zhang, Mengsu Yang, Qing Wang, Niu Huang, Chao Su, Pengcheng Han, Zengyuan Zhang, Yu Hu, Heecheol Cho, Hanyi Liao, Weiwei Li, Jianxun Qi, Xiaoyu Rong, Xin Zhao, Chongzhi Bai, Qian Chen, Jinghua Yan, George F. Gao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some have been linked to an increase in case numbers globally. However, there is yet a lack of understanding of the molecular basis for the interactions between the human ACE2 (hAC
Autor:
Min Huang, Lili Wu, Anqi Zheng, Yufeng Xie, Qingwen He, Xiaoyu Rong, Pu Han, Pei Du, Pengcheng Han, Zengyuan Zhang, Runchu Zhao, Yunfei Jia, Linjie Li, Bin Bai, Ziliang Hu, Shixiong Hu, Sheng Niu, Yu Hu, Honghui Liu, Bo Liu, Kaige Cui, Weiwei Li, Xin Zhao, Kefang Liu, Jianxun Qi, Qihui Wang, George Fu Gao
Publikováno v:
Immunity. 55(8)
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal antibodies (mAbs), covering the seven identified epitope classes of the SARS-Co
Autor:
Min Huang, Lili Wu, Anqi Zheng, Yufeng Xie, Qingwen He, Xiaoyu Rong, Pu Han, Pei Du, Pengcheng Han, Zengyuan Zhang, Runchu Zhao, Yunfei Jia, Linjie Li, Bin Bai, Ziliang Hu, Shixiong Hu, Sheng Niu, Yu Hu, Honghui Liu, Bo Liu, Kaige Cui, Weiwei Li, Xin Zhao, Kefang Liu, Jianxun Qi, Qihui Wang, George F. Gao
Publikováno v:
SSRN Electronic Journal.
Autor:
Zheng Fan, Yanfang Zhang, Zhou Tong, Xin Zhao, Yeping Sun, Haixia Xiao, Anqi Zheng, Huifang Li, Hanyi Liao, Jianxun Qi, Sufang Ma, Liang Wang, Qingling Wang, Yuhai Bi, George F. Gao, Yan Li, Yuqin Zhang, Qiong Lu, Kefang Liu, Zengyuan Zhang, Qihui Wang, Weijin Huang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
SARS-CoV-2 can infect many domestic animals, including dogs. Herein, we show that dog angiotensin-converting enzyme 2 (dACE2) can bind to the SARS-CoV-2 spike (S) protein receptor binding domain (RBD), and that both pseudotyped and authentic SARS-CoV