Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Zengping Duan"'
Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Peptides are valuable for therapeutic development, with multicyclic peptides showing promise in mimicking antigen-binding potency of antibodies. However, our capability to engineer multicyclic peptide scaffolds, particularly for the construc
Externí odkaz:
https://doaj.org/article/27b038a97272432595442038f638ddda
Autor:
Xiaoting Meng, Chaoying Xu, Shihui Fan, Meng Dong, Jie Zhuang, Zengping Duan, Yibing Zhao, Chuanliu Wu
Publikováno v:
Chemical Science. 14:3668-3675
A selection system leveraging cellular protein quality control (termed PQC-select) has been designed to select DRPs with robust foldability from random sequences, providing valuable scaffolds for developing peptide-based probes or therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5959a63623dd580bdb6edf7fc418921
https://doi.org/10.1039/d2sc05343h
https://doi.org/10.1039/d2sc05343h
Publikováno v:
Chemical science. 12(34)
Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. However, there are only a limited number of topologically distinct DRP folds in nature, and most of them suffer from the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89a1f14411025103c7773f1fd349320
https://pubmed.ncbi.nlm.nih.gov/34567500
https://pubmed.ncbi.nlm.nih.gov/34567500