Výsledky vyhledávání - "Zengping Duan"

Akademický článek

Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders

Autor: Zengping Duan, Chuilian Kong, Shihui Fan, Chuanliu Wu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Peptides are valuable for therapeutic development, with multicyclic peptides showing promise in mimicking antigen-binding potency of antibodies. However, our capability to engineer multicyclic peptide scaffolds, particularly for the construc

Externí odkaz: https://doaj.org/article/27b038a97272432595442038f638ddda

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Selection and evolution of disulfide-rich peptides via cellular protein quality control

Autor: Xiaoting Meng, Chaoying Xu, Shihui Fan, Meng Dong, Jie Zhuang, Zengping Duan, Yibing Zhao, Chuanliu Wu

Publikováno v: Chemical Science. 14:3668-3675

A selection system leveraging cellular protein quality control (termed PQC-select) has been designed to select DRPs with robust foldability from random sequences, providing valuable scaffolds for developing peptide-based probes or therapeutics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5959a63623dd580bdb6edf7fc418921
https://doi.org/10.1039/d2sc05343h

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An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation

Autor: Jun Zha, Jinjing Li, Yibing Zhao, Shihui Fan, Zengping Duan, Chuanliu Wu

Publikováno v: Chemical science. 12(34)

Natural disulfide-rich peptides (DRPs) are valuable scaffolds for the development of new bioactive molecules and therapeutics. However, there are only a limited number of topologically distinct DRP folds in nature, and most of them suffer from the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89a1f14411025103c7773f1fd349320
https://pubmed.ncbi.nlm.nih.gov/34567500

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