Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Zengdun, Shi"'
Autor:
Xiaoying Liu, Sarah A. Taylor, Kyle D. Gromer, Danny Zhang, Susan C. Hubchak, Brian E. LeCuyer, Takao Iwawaki, Zengdun Shi, Don C. Rockey, Richard M. Green
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of liver diseases in the United States and can progress to cirrhosis, end-stage liver disease and need for liver transplantation. There are limited therapies for NAFLD, in part
Externí odkaz:
https://doaj.org/article/93dc9610f3cd45d8919bdb1217e37370
Publikováno v:
BIOCELL. 46:2003-2007
Hepatic stellate cells (HSCs) are the primary effector cells in liver fibrosis. In the normal liver, HSCs serve as the primary vitamin A storage cells in the body and retain a "quiescent" phenotype. However, after liver injury, they transdifferentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1276f3bd1f152b6c7abfd92346dbf494
https://doi.org/10.32604/biocell.2022.020171
https://doi.org/10.32604/biocell.2022.020171
Publikováno v:
Histochemistry and cell biology. 158(4)
Ongoing liver injury leads to fibrosis and ultimately cirrhosis, a leading cause of death worldwide. The primary mechanism underlying the fibrogenic response is the activation of cells known as hepatic stellate cells (HSCs) which are "quiescent" in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d868e537670fc4f594cc2c8e8d4d70
https://pubmed.ncbi.nlm.nih.gov/35960334
https://pubmed.ncbi.nlm.nih.gov/35960334
Autor:
Zhentao Zhang, Wenhui Zhang, Robert Blakes, Lauren J. Sundby, Zengdun Shi, Don C. Rockey, James M. Ervasti, Young-Jae Nam
Publikováno v:
Stem cell reports. 17(7)
Fibroblasts can be reprogrammed into induced cardiomyocyte-like cells (iCMs) by forced expression of cardiogenic transcription factors. However, it remains unknown how fibroblasts adopt a cardiomyocyte (CM) fate during their spontaneous ongoing trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578a111cfd6d128af7a430625edd7544
https://pubmed.ncbi.nlm.nih.gov/35688153
https://pubmed.ncbi.nlm.nih.gov/35688153
Publikováno v:
Biocell; 2022, Vol. 46 Issue 9, p2003-2007, 5p
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77166 (2013)
Smooth muscle α actin (Acta2) expression is largely restricted to smooth muscle cells, pericytes and specialized fibroblasts, known as myofibroblasts. Liver injury, associated with cirrhosis, induces transformation of resident hepatic stellate cells
Externí odkaz:
https://doaj.org/article/86dae0dfb6f841aa96e24eae27ee8b37
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Activation of hepatic stellate cells (HSCs), characterized by development of a robust actin cytoskeleton and expression of abundant extracellular matrix (ECM) proteins, such as type 1 collagen (COL.1), is a central cellular and molecular event in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e23911cb8992124c8a2a327b5e38927
https://europepmc.org/articles/PMC7099496/
https://europepmc.org/articles/PMC7099496/
Publikováno v:
Am J Pathol
In the liver, smooth muscle α-actin (SM α-actin) is up-regulated in hepatic stellate cells (HSCs) as they transition to myofibroblasts during liver injury and the wound healing response. Whether SM α-actin has specific functional effects on cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00db701d9f87fc83315b59b129cc33f9
https://pubmed.ncbi.nlm.nih.gov/32433909
https://pubmed.ncbi.nlm.nih.gov/32433909
Publikováno v:
American Journal of Physiology: Gastrointestinal & Liver Physiology; Mar2020, Vol. 318 Issue 3, pG504-G517, 14p
Autor:
Zengdun Shi, Don C. Rockey
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Liver fibrosis, a model wound healing system, is characterized by excessive deposition of extracellular matrix (ECM) in the liver. Although many fibrogenic cell types may express ECM, the hepatic stellate cell (HSC) is currently considered to be the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab6dd8b2881f541f3613f00039f455a
https://pubmed.ncbi.nlm.nih.gov/29035375
https://pubmed.ncbi.nlm.nih.gov/29035375