Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Zenele Mncube"'
Autor:
Kamini Gounder, Nagavelli Padayachi, Jaclyn K Mann, Mopo Radebe, Mammekwa Mokgoro, Mary van der Stok, Lungile Mkhize, Zenele Mncube, Manjeetha Jaggernath, Tarylee Reddy, Bruce D Walker, Thumbi Ndung'u
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119886 (2015)
In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven selection pressure in Gag from the time of acute infection are limited. In this study we exami
Externí odkaz:
https://doaj.org/article/2fa256d7af9645c3a346388a58734015
Autor:
Philippa C Matthews, Jennifer Listgarten, Jonathan M Carlson, Rebecca Payne, Kuan-Hsiang Gary Huang, John Frater, Dominique Goedhals, Dewald Steyn, Cloete van Vuuren, Paolo Paioni, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Zenele Mncube, Thumbi Ndung'u, Bruce D Walker, David Heckerman, Philip J R Goulder
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47799 (2012)
BACKGROUND:HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage di
Externí odkaz:
https://doaj.org/article/223ab9c411464a6d9824377365c855a0
Autor:
Danni Ramduth, Cheryl L Day, Christina F Thobakgale, Nompumelelo P Mkhwanazi, Chantal de Pierres, Sharon Reddy, Mary van der Stok, Zenele Mncube, Kriebashne Nair, Eshia S Moodley, Daniel E Kaufmann, Hendrik Streeck, Hoosen M Coovadia, Photini Kiepiela, Philip J R Goulder, Bruce D Walker
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5013 (2009)
A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This association has not been investigated in
Externí odkaz:
https://doaj.org/article/ee88e71953b84f48aebb816035d8099c
Autor:
Sindiswa Nkotwana, Thumbi Ndung'u, Marcusa Altfeld, Kewreshini K. Naidoo, Maja Ziegler, Zenele Mncube, Nasreen Ismael, Philipb Goulder, Jaclyn K. Mann, Anais Chapel, Christina F. Thobakgale
Publikováno v:
AIDS. 35:151-154
HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leukocyte antigen class I (HLA-I) molecules modulating natural killer cell function. HIV-1 strains encoding amino acids that mediate bind
Autor:
Zenele Mncube, Christina F. Thobakgale, Marcus Altfeld, Michael Z. Zulu, Kewreshini K. Naidoo, Manjeetha Jaggernath, Philip J. R. Goulder, Thumbi Ndung'u
Publikováno v:
AIDS Research and Human Retroviruses. 33:1205-1213
HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alteration
Autor:
Michael Z, Zulu, Kewreshini K, Naidoo, Zenele, Mncube, Manjeetha, Jaggernath, Philip J R, Goulder, Thumbi, Ndung'u, Marcus, Altfeld, Christina F, Thobakgale
Publikováno v:
AIDS research and human retroviruses. 33(12)
HIV-1 viremia has been shown to induce several phenotypic and functional abnormalities in natural killer (NK) cells. To assess immune defects associated with HIV viremia, we examined NK cell function, differentiation status, and phenotypic alteration
Autor:
Nonhlanhla Yende, Zaza M. Ndhlovu, Lungile Mkhize, Catherine K. Koofhethile, Christina F. Thobakgale-Tshabalala, Nasreen Ismail, Bruce D. Walker, Thumbi Ndung'u, Philip J. R. Goulder, Mary van der Stok, Julia G. Prado, Zenele Mncube
Publikováno v:
Journal of Virology
The mechanisms of viral control and loss of viral control in chronically infected individuals with or without protective HLA class I alleles are not fully understood. We therefore characterized longitudinally the immunological and virological feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa4cb24b1e68de214c30337df42bb8
https://hdl.handle.net/11858/00-001M-0000-002B-A5FA-C21.11116/0000-0003-E254-F
https://hdl.handle.net/11858/00-001M-0000-002B-A5FA-C21.11116/0000-0003-E254-F
Autor:
Zabrina L. Brumme, Toshiyuki Miura, Bruce D. Walker, Fundisiwe Chonco, Mary van der Stok, Mark A. Brockman, Carl M. Kadie, Chanson J. Brumme, Jaclyn K. Wright, Elena Losina, Zenele Mncube, David Heckerman, Jonathan M. Carlson, Philip J. R. Goulder, Karen S. Bishop, Thumbi Ndung'u, Bingxia Wang
The mechanisms underlying HIV-1 control by protective HLA class I alleles are not fully understood and could involve selection of escape mutations in functionally important Gag epitopes resulting in fitness costs. This study was undertaken to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4130c8554e70f55674ba7545dcefbb
https://ora.ox.ac.uk/objects/uuid:5489e532-141d-43c6-aac3-bee90a6a8cd6
https://ora.ox.ac.uk/objects/uuid:5489e532-141d-43c6-aac3-bee90a6a8cd6
Autor:
Marcus Altfeld, Jaclyn K. Wright, Fundisiwe Chonco, Kriebashnie Nair, Karen S. Bishop, Mary van der Stok, Zenele Mncube, Mopo Radebe, Ingrid V. Bassett, Bruce D. Walker, Thumbi Ndung'u
Publikováno v:
The Journal of Infectious Diseases. 204:768-776
Background. Human immunodeficiency virus type 1 (HIV-1)–specific CD8+ responses contribute to the decline in acute peak viremia following infection. However, data on the relative immunogenicity of CD8+ T-cell epitopes during and after acute viremia
Autor:
Zenele Mncube, Ying Qi, Eshia Moodley, Shabashini Reddy, Roger Detels, Bruce D. Walker, Thumbi Ndung'u, Philip J. R. Goulder, Danni Ramduth, Mary Carrington, Boris Julg, Xiaojiang Gao
Publikováno v:
The Journal of Infectious Diseases. 203:803-809
CD4+ T cells play a pivotal role in adaptive immunity, because they are required for the development and maintenance of memory and cytotoxic CD8+ T cells [1–4]. On the other hand, human immunodeficiency virus (HIV)–specific CD4+ T cells serve as