Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Zenaide M.N. Quezado"'
Autor:
Li Wang, Aili Wang, William W. Supplee, Kayla Koffler, Ying Cheng, Zenaide M.N. Quezado, Richard J. Levy
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 550-556 (2017)
The data presented here detail the changes in size, cellular content, and neuronal density of the developing brain over time with respect to sex in C57Bl/6 mice following neonatal exposure to isoflurane, carbon monoxide, or their combination. Specifi
Externí odkaz:
https://doaj.org/article/4d64bdb44e324c24a228cb0f9787531d
Autor:
Li Wang, Luis E.F. Almeida, Celia M. de Souza Batista, Alfia Khaibullina, Nuo Xu, Sarah Albani, Kira A. Guth, Ji Sung Seo, Martha Quezado, Zenaide M.N. Quezado
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 60-72 (2016)
Strokes are perhaps the most serious complications of sickle cell disease (SCD) and by the fifth decade occur in approximately 25% of patients. While most patients do not develop strokes, mounting evidence indicates that even without brain abnormalit
Externí odkaz:
https://doaj.org/article/926cf95afd564c0b87a3ca481f00a5b3
Autor:
Alfia Khaibullina, Elena A. Adjei, Nowah Afangbedji, Andrey Ivanov, Namita Kumari, Luis E.F. Almeida, Zenaide M.N. Quezado, Sergei Nekhai, Marina Jerebtsova
Publikováno v:
Haematologica, Vol 103, Iss 5 (2018)
Sickle cell disease patients are at increased risk of developing a chronic kidney disease. Endothelial dysfunction and inflammation associated with hemolysis lead to vasculopathy and contribute to the development of renal disease. Here we used a Town
Externí odkaz:
https://doaj.org/article/9e5ea2f79f0b41c7b6fc46474f12e3f2
Publikováno v:
Expert review of hematology. 15(10)
Patients with sickle cell disease (SCD) present recurrent episodes of acute pain, the hallmark of the disease, and some will also develop chronic pain. Currently, the treatment of SCD acute pain only targets its symptoms, rather than underlying mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56828c0629c203116ecc6f9dc3529205
https://pubmed.ncbi.nlm.nih.gov/36191299
https://pubmed.ncbi.nlm.nih.gov/36191299
Publikováno v:
Exp Biol Med (Maywood)
Sickle cell disease is the most common hemoglobinopathy and affects millions worldwide. The disease is associated with severe organ dysfunction, acute and chronic pain, and significantly decreased life expectancy. The large body of work demonstrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de97f74511593b8265ad140a2c7c69b
https://doi.org/10.1177/1535370220976397
https://doi.org/10.1177/1535370220976397
Autor:
Laxminath Tumburu, Mehdi Pirooznia, Arun S. Shet, Luis E.F. Almeida, James S. Nichols, Jun Zhu, Eric Lindberg, Maliha Maryam Ahmad, Christopher K. E. Bleck, Ilker Tunc, Ishwarya Sivakumar, Christian A. Combs, Emilia Alina Barbu, Fayaz Seifuddin, Lauren H. W. Wilkins, Swee Lay Thein, Shohini Ghosh-Choudhary, Shutong Yang, Simon Yang, Pradeep K. Dagur, Zenaide M.N. Quezado, Jay H. Chung
Publikováno v:
Blood
The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA (cfDNA) in patients with SCD is not just a prognostic biomarker, it also co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd088c5875ba43424f5c0c86979f0f0
https://europepmc.org/articles/PMC8176765/
https://europepmc.org/articles/PMC8176765/
Autor:
Zenaide M.N. Quezado, Sayuri Kamimura, Meghann Smith, Xunde Wang, Michael R. Heaven, Sirsendu Jana, Sebastian Vogel, Patricia Zerfas, Christian A. Combs, Luis E.F. Almeida, Quan Li, Martha Quezado, Iren Horkayne-Szakaly, Penelope A. Kosinski, Shaoxia Yu, Unnati Kapadnis, Charles Kung, Lenny Dang, Paul Wakim, William A. Eaton, Abdu I. Alayash, Swee Lay Thein
Publikováno v:
Blood Cells Mol Dis
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, factors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fae3b20d22c75bd489e292ed02baa27
https://doi.org/10.1016/j.bcmd.2022.102660
https://doi.org/10.1016/j.bcmd.2022.102660
Autor:
Sayuri Kamimura, Luis E.F. Almeida, Zenaide M.N. Quezado, Taruna Arora, Christian A. Combs, Meghann L. Smith, Sebastian Vogel, Swee Lay Thein
Publikováno v:
Biochem Biophys Res Commun
The nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) inflammasome is a critical inflammatory mechanism identified in platelets, which controls platelet activation and aggregation. We have recently shown that the platelet NLR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115f1a5a4d74226bd980bba94aa52afa
https://pubmed.ncbi.nlm.nih.gov/33831782
https://pubmed.ncbi.nlm.nih.gov/33831782
Autor:
Jack H. Van der Meulen, Zenaide M.N. Quezado, Martha Quezado, Luis E.F. Almeida, Sayuri Kamimura, Kanneboyina Nagaraju, Li Wang, Paul Wakim
Publikováno v:
Nitric Oxide. 80:70-81
Sickle cell disease (SCD) patients can have limited exercise capacity and muscle dysfunction characterized by decreased force, atrophy, microvascular abnormalities, fiber distribution changes, and skeletal muscle energetics abnormalities. Growing evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5bede5ae6e85a6e15b6c635ebffc4b
https://doi.org/10.1016/j.niox.2018.08.005
https://doi.org/10.1016/j.niox.2018.08.005
Autor:
Sebastian Vogel, Swee Lay Thein, Zenaide M.N. Quezado, James S. Nichols, Taruna Arora, Laurel Mendelsohn, Xunde Wang, Arun S. Shet, Darlene Allen, Christian A. Combs
Publikováno v:
Blood Advances. 2:2672-2680
A key inflammatory mechanism recently identified in platelets involves the Nod-like receptor nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK), which control activation of caspase-1 within inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26406e723e23bfe96d742ca16d17b5e5
https://doi.org/10.1182/bloodadvances.2018021709
https://doi.org/10.1182/bloodadvances.2018021709