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pro vyhledávání: '"Zenab Lightwala"'
Autor:
Zenab Lightwala, Romany L. Stansborough, Joseph Shirren, Rachel J. Gibson, Ysabella Z.A. Van Sebille, Anthony Wignall, Imogen A. Ball, Kate R. Secombe, Hannah R. Wardill, Joanne M. Bowen, Janet K. Coller
Publikováno v:
Cancer chemotherapy and pharmacology. 79(2)
Purpose: Irinotecan-induced gut toxicity is mediated in part by Toll-Like receptor 4 (TLR4) signalling. The primary purpose of this preclinical study was to determine whether blocking TLR4 signalling by administering (−)-naloxone, a TLR4 antagonist