Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Zen Itoh"'
Publikováno v:
Arzneimittelforschung. 49:618-625
The present study was undertaken to clarify a prokinetic activity of nizatidine (CAS 76963-41-2) during the digestive state as well as gastric emptying of a solid test meal in comparison with cimetidine (CAS 51481-61-9), famotidine (CAS 76842-35-6) a
Autor:
Satoshi Omura, Shuji Hayashi, Etsuko Fujii, Atsuhiko Kato, Hisanori Takanashi, Zen Itoh, Kazuya Kimura, Tetsuro Sugimoto, Hideki Wanibuchi, Keiji Mizoguchi, Masami Suzuki
Publikováno v:
Toxicologic Pathology. 36:858-865
Mitemcinal is an erythromycin derivative with motilin agonistic action, developed as a gastrointestinal motor-activating agent. The characteristics of mitemcinal-induced multinuclear hepatocytes (MNHs, hepatocytes with three or more nuclei per cell)
Autor:
Zen Itoh, Hiroyasu Muramatsu, Kenshi Kamei, Satoshi Ōmura, Hisanori Takanashi, Saori Matsuo, Kenji Yogo, Mitsu Onoma, Yoshiki Kawabe, Shuji Hayashi, Makoto Monnai, Masami Suzuki, Toshihiko Shiga, Ken-ichi Ozaki
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 35:788-796
SUMMARY 1 The aim of the present study was to evaluate the effects of mitemcinal (GM-611), an orally active motilin receptor agonist, on delayed gastric emptying in a canine model of diabetic gastroparesis and to compare these effects with those of c
Publikováno v:
Neurogastroenterology & Motility. 1:131-137
The effect of intravenous infusion of 5-hydroxytryptamine (5-HT) on gastrointestinal contractile activity was studied in conscious dogs during the digestive and interdigestive states. It was found that 30 to 300 μg/kg per hour of 5-HT induced phasic
Publikováno v:
Neurogastroenterology & Motility. 5:9-16
Autor:
Zen Itoh, Yuji Iwanaga, Naoshi Miyashita, Akiyoshi Mizumoto, Yoichi Kondo, Naoyuki Yoshida, Masaki Fujimura
Publikováno v:
Neurogastroenterology & Motility. 2:273-280
We studied the anticholinesterase activity of three H2-receptor antagonists (cimetidine, ranitidine, and famotidine) in vitro and in conscious dogs with chronically implanted strain-gauge force transducers. In vivo, acetylcholine (ACh) was infused in
Autor:
Etsuko Fujii, Kazuya Kimura, Masami Suzuki, Zen Itoh, Atsuhiko Kato, Keiji Mizoguchi, Satoshi Ōmura, Hisanori Takanashi
Publikováno v:
Toxicology and Applied Pharmacology. 228:1-7
Mitemcinal is an erythromycin derivative, which acts as an agonist of the motilin receptor. For assessment of the carcinogenicity of mitemcinal, we conducted a short-term carcinogenicity study in p53 (+/-) C57BL/6 mice and a 104-week carcinogenicity
Publikováno v:
Digestive Diseases and Sciences. 52:3112-3122
Neither the presence of motilin receptors nor their action has been investigated in monkeys. The object of this study was to determine the effects of motilin and mitemcinal (GM-611), an erythromycin derivative, on the gastrointestinal tract in rhesus
Autor:
Ken-ichi Ozaki, Hisanori Takanashi, Hiroyasu Muramatsu, Kenshi Kamei, Omura S, Osamu Cynshi, Zen Itoh, Kenji Yogo, Hirokazu Sudo, Hiroshi Koga
Publikováno v:
Neurogastroenterology & Motility. 19:318-326
The effects of mitemcinal (GM-611), an orally active motilin agonist, on defecation were investigated in rabbits and dogs. In normal rabbits, within 0-3 h of dosing, orally administered mitemcinal (2.5-10 mg kg(-1)) increased stool weight in a dose-d
Autor:
Kazuya Kimura, Mitsuyasu Tabo, Atsuhiko Kato, Keiji Mizoguchi, Satoshi Omura, Zen Itoh, Hisanori Takanashi, Misae Itoh, Masami Suzuki
Publikováno v:
The Journal of Toxicological Sciences. 32:217-230
Mitemcinal (GM-611) is a novel erythromycin-derived prokinetic agent that acts as an agonist at the motilin receptor. Erythromycin has shown QT prolongation and torsades de pointes (TdP) in humans and cisapride, a second class of prokinetic agents ty