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Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD.

Autor: Garcés, Polett, Amaro, Armando, Montecino, Martin, van Zundert, Brigitte

Publikováno v: Biochemical Society Transactions; Feb2024, Vol. 52 Issue 1, p123-135, 13p

A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens.

Autor: Mattson NM; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Chan AKN; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.; Division of Epigenetic and Transcriptional Engineering, Beckman Research Institute, City of Hope, Duarte, CA, USA., Miyashita K; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Mukhaleva E; Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, CA, USA., Chang WH; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Yang L; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.; Division of Epigenetic and Transcriptional Engineering, Beckman Research Institute, City of Hope, Duarte, CA, USA., Ma N; Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, CA, USA., Wang Y; Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, CA, USA., Pokharel SP; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.; Division of Epigenetic and Transcriptional Engineering, Beckman Research Institute, City of Hope, Duarte, CA, USA., Li M; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Liu Q; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Xu X; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Chen R; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Singh P; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Zhang L; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Elsayed Z; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Chen B; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Keen D; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Pirrotte P; Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Rosen ST; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chen J; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., LaBarge MA; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA., Shively JE; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Department of Immunology and Theranostics, Beckman Research Institute, City of Hope, Duarte, CA, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, CA, USA.; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Rockne RC; Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, CA, USA.; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Feng M; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Department of Immuno-Oncology, Beckman Research Institute, City of Hope, Duarte, CA, USA., Chen CW; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA. cweichen@coh.org.; Division of Epigenetic and Transcriptional Engineering, Beckman Research Institute, City of Hope, Duarte, CA, USA. cweichen@coh.org.; City of Hope Comprehensive Cancer Center, Duarte, CA, USA. cweichen@coh.org.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Mar; Vol. 31 (3), pp. 465-475. Date of Electronic Publication: 2024 Feb 05.

Inorganic pyrophosphatase from the red flour beetle (Tribolium castaneum) modulates mitochondrial polyphosphate metabolism.

Autor: Mirra, Bianca, Carvalho, Klébea, Curitiba, Bianca, Ribeiro, Lupis, Moraes, Jorge, da Silva, José R., Costa, Evenilton P., da Fonseca, Rodrigo N., Campos, Eldo

Publikováno v: Archives of Insect Biochemistry & Physiology; Dec2019, Vol. 102 Issue 4, pN.PAG-N.PAG, 1p