Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group.

Autor: Morland K; Global Medical Affairs United Therapeutics Corporation Research Triangle Park North Carolina USA., Gerges C; Department of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria., Elwing J; Division of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Cincinnati Ohio USA., Visovatti SH; Division of Cardiovascular Medicine The Ohio State University Columbus Ohio USA., Weatherald J; Department of Medicine, Division of Pulmonary Medicine University of Alberta Edmonton Canada., Gillmeyer KR; The Pulmonary Center Boston University Chobian & Avedisian School of Medicine Boston Massachusetts USA.; Center for Healthcare Organization & Implementation Research VA Bedford Healthcare System and VA Boston Healthcare System Bedford Massachusetts USA., Sahay S; Division of Pulmonary, Critical Care & Sleep Medicine Houston Methodist Hospital Houston Texas USA., Mathai SC; Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA., Boucly A; Faculté de Médecine Université Paris-Saclay Le Kremlin-Bicêtre France.; Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre Assistance Publique Hôpitaux de Paris Le Kremlin Bicêtre France.; National Heart and Lung Institute Imperial College London UK., Williams PG; Center of Chest Diseases & Critical Care Milpark Hospital Johannesburg South Africa., Harikrishnan S; Sree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala India., Minty EP; Department of Medicine & O'Brien Institute for Public Health University of Calgary Calgary Canada., Hobohm L; Department of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.; Center for Thrombosis and Hemostasis (CTH) University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany., Jose A; Division of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Cincinnati Ohio USA., Badagliacca R; Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome Policlinico Umberto I Rome Italy., Lau EMT; Department of Respiratory Medicine, Royal Prince Alfred Hospital University of Sydney Camperdown New South Wales Australia.; Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia., Jing ZC; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China., Vanderpool RR; Division of Cardiovascular Medicine The Ohio State University Columbus Ohio USA., Fauvel C; Service de Cardiologie, Centre de Compétence en Hypertension Pulmonaire 27/76, Centre Hospitalier Universitaire Charles Nicolle, INSERM EnVI U1096 Université de Rouen Rouen France., Leonidas Alves J Jr; Pulmonary Division, Heart Institute University of São Paulo Medical School São Paulo Brazil., Strange G; School of Medicine The University of Notre Dame Australia Perth Western Australia Australia., Pulido T; Ignacio Chávez National Heart Institute México City Mexico., Qian J; Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China., Li M; Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China., Mercurio V; Department of Translational Medical Sciences Federico II University Naples Italy., Zelt JGE; Department of Medicine, Faculty of Medicine University of Ottawa Ottawa Canada., Moles VM; Division of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA., Cirulis MM; Division of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA.; Department of Pulmonary and Critical Care Medicine Intermountain Medical Center Murray Salt Lake City Utah USA., Nikkho SM; Global Clinical Development Bayer AG Berlin Germany., Benza RL; Mount Sinai Heart Icahn School of Medicine at Mount Sinai New York New York USA., Elliott CG; Division of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA.; Department of Pulmonary and Critical Care Medicine Intermountain Medical Center Murray Salt Lake City Utah USA.

Publikováno v: Pulmonary circulation [Pulm Circ] 2023 Dec 21; Vol. 13 (4), pp. e12317. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).

Pharmacological and metabolic parameters of [ ¹⁸ F]flubrobenguane in clinical imaging populations.

Autor: Mair BA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Zelt JGE; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.; Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada., Nekesa K; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Saint-Georges Z; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.; The University of Ottawa Institute of Mental Health Research at the Royal, Ottawa, Canada., Dinelle K; The University of Ottawa Institute of Mental Health Research at the Royal, Ottawa, Canada., Adi M; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada.; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Robinson S; Lantheus Medical Imaging, Inc, North Billerica, MA, USA., Mielniczuk LM; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Shlik J; The University of Ottawa Institute of Mental Health Research at the Royal, Ottawa, Canada.; Department of Psychiatry, University of Ottawa, Ottawa, Canada., Beanlands RS; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., deKemp RA; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. radekemp@ottawaheart.ca., Rotstein BH; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada. benjamin.rotstein@uottawa.ca.; University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. benjamin.rotstein@uottawa.ca.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada. benjamin.rotstein@uottawa.ca.

Publikováno v: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2023 Oct; Vol. 30 (5), pp. 2089-2095. Date of Electronic Publication: 2023 Jul 26.

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics.

Autor: Zelt JGE; Molecular Function and Imaging Program, The National Cardiac PET Centre, and Advanced Heart Disease Program, Division of Cardiology, Department of Medicine (J.G.E.Z., R.d., R.B., L.M.M., D.J.S.), University of Ottawa, Canada.; Department of Medicine, Faculty of Medicine (J.G.E.Z., R.B., L.M.M., D.J.S.), University of Ottawa, Canada., Cadete V; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.)., Deng Y; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.)., Godoy R; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.)., Cuillerier A; Faculty of Health Sciences (A.C., Y.B.), University of Ottawa, Canada., Rowe K; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.)., Abdul-Ghani M; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.)., Megeney L; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.)., Burelle Y; Faculty of Health Sciences (A.C., Y.B.), University of Ottawa, Canada., Giulivi A; Eastern Ontario Regional Laboratory Association (A.G.)., Stewart AFR; Laboratory of Translational Genomics (A.F.R.S.), University of Ottawa Heart Institute, Canada.; Department of Biochemistry, Immunology and Microbiology (A.F.R.S., D.J.S.), University of Ottawa, Canada., Provencher S; Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada (S.P., S.B.-B., S.B.).; Department of Medicine, Université Laval, Québec, Canada (S.P., S.B.-B., S.B.)., Breuils-Bonnet S; Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada (S.P., S.B.-B., S.B.).; Department of Medicine, Université Laval, Québec, Canada (S.P., S.B.-B., S.B.)., Bonnet S; Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada (S.P., S.B.-B., S.B.).; Department of Medicine, Université Laval, Québec, Canada (S.P., S.B.-B., S.B.)., deKemp R; Molecular Function and Imaging Program, The National Cardiac PET Centre, and Advanced Heart Disease Program, Division of Cardiology, Department of Medicine (J.G.E.Z., R.d., R.B., L.M.M., D.J.S.), University of Ottawa, Canada., Beanlands R; Molecular Function and Imaging Program, The National Cardiac PET Centre, and Advanced Heart Disease Program, Division of Cardiology, Department of Medicine (J.G.E.Z., R.d., R.B., L.M.M., D.J.S.), University of Ottawa, Canada.; Department of Medicine, Faculty of Medicine (J.G.E.Z., R.B., L.M.M., D.J.S.), University of Ottawa, Canada., Mielniczuk LM; Molecular Function and Imaging Program, The National Cardiac PET Centre, and Advanced Heart Disease Program, Division of Cardiology, Department of Medicine (J.G.E.Z., R.d., R.B., L.M.M., D.J.S.), University of Ottawa, Canada.; Department of Medicine, Faculty of Medicine (J.G.E.Z., R.B., L.M.M., D.J.S.), University of Ottawa, Canada., Stewart DJ; Molecular Function and Imaging Program, The National Cardiac PET Centre, and Advanced Heart Disease Program, Division of Cardiology, Department of Medicine (J.G.E.Z., R.d., R.B., L.M.M., D.J.S.), University of Ottawa, Canada.; Department of Medicine, Faculty of Medicine (J.G.E.Z., R.B., L.M.M., D.J.S.), University of Ottawa, Canada.; Department of Biochemistry, Immunology and Microbiology (A.F.R.S., D.J.S.), University of Ottawa, Canada.; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (V.C., Y.D., R.G., K.R., M.A.-G., L.M., D.J.S.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2022 Dec; Vol. 79 (12), pp. 2774-2786. Date of Electronic Publication: 2022 Oct 24.

Mortality trends in pulmonary arterial hypertension in Canada: a temporal analysis of survival per ESC/ERS guideline era.

Autor: Zelt JGE; Dept of Cellular and Molecular Medicine and Dept of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada., Sugarman J; Internal Medicine Residency Program, Dept of Medicine, University of Calgary, Calgary, AB, Canada., Weatherald J; Division of Respirology, Dept of Medicine, University of Calgary, Calgary, AB, Canada.; Libin Cardiovascular Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada., Partridge ACR; Dept of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Liang JC; Dept of Cellular and Molecular Medicine and Dept of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Swiston J; Division of Respirology, University of British Columbia, Vancouver, BC, Canada., Brunner N; Division of Cardiology, University of British Columbia, Vancouver, BC, Canada., Chandy G; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada.; Division of Respirology and Internal Medicine, University of Ottawa, Ottawa, ON, Canada., Stewart DJ; Dept of Cellular and Molecular Medicine and Dept of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada.; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Contreras-Dominguez V; Division of Respirology and Internal Medicine, University of Ottawa, Ottawa, ON, Canada., Thakrar M; Division of Respirology, Dept of Medicine, University of Calgary, Calgary, AB, Canada., Helmersen D; Division of Respirology, Dept of Medicine, University of Calgary, Calgary, AB, Canada., Varughese R; Division of Respirology, Dept of Medicine, University of Calgary, Calgary, AB, Canada.; Division of Pulmonary Medicine, Dept of Medicine, University of Alberta, Edmonton, AB, Canada., Hirani N; Division of Respirology, Dept of Medicine, University of Calgary, Calgary, AB, Canada., Umar F; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada., Dunne R; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada., Doyle-Cox C; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada., Foxall J; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada., Mielniczuk L; Dept of Cellular and Molecular Medicine and Dept of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada lmielniczuk@ottawaheart.ca.; Division of Cardiology, University of Ottawa Heart Institute and University of Ottawa, Ottawa, ON, Canada.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Jun 02; Vol. 59 (6). Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).

Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients.

Autor: Ahmadi A; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Renaud JM; National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada., Promislow S; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Burwash IG; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada., Dwivedi G; Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Australia., Klein R; Division of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Zelt JGE; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., deKemp RA; National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada., Beanlands RS; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.; National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada., Mielniczuk LM; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. lmielniczuk@ottawaheart.ca.

Publikováno v: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2021 Dec; Vol. 28 (6), pp. 2784-2795. Date of Electronic Publication: 2020 May 07.