Osteomyelitis-relevant antibiotics at clinical concentrations show limited effectivity against acute and chronic intracellular S. aureus infections in osteocytes.

Autor: Zelmer AR; Center for Orthopedic and Trauma Research, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia., Yang D; Center for Orthopedic and Trauma Research, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia., Gunn NJ; Center for Orthopedic and Trauma Research, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia., Solomon LB; Center for Orthopedic and Trauma Research, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Department of Orthopedics and Trauma, Royal Adelaide Hospital, Adelaide, Australia., Nelson R; Department of Infectious Diseases, Central Adelaide Local Health Network, Adelaide, Australia., Kidd SP; Australian Center for Antimicrobial Resistance Ecology, University of Adelaide, Adelaide, Australia.; Research Center for Infectious Disease, School of Biological Science, University of Adelaide, Adelaide, Australia., Richter K; Department of Surgery, Richter Lab, Basil Hetzel Institute for Translational Health Research, University of Adelaide, Adelaide, Australia.; Institute for Photonics and Advanced Sensing, University of Adelaide, Adelaide, Australia., Atkins GJ; Center for Orthopedic and Trauma Research, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Oct 08; Vol. 68 (10), pp. e0080824. Date of Electronic Publication: 2024 Aug 28.

The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section.

Autor: Hickok NJ; Department of Orthopaedic Surgery, Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Li B; Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia, USA., Oral E; Harris Orthopaedic Laboratory, Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Zaat SAJ; Department of Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Armbruster DA; DePuy Synthes Biomaterials, West Chester, Pennsylvania, USA., Atkins GJ; Centre for Orthopaedic and Trauma Research, University of Adelaide, Adelaide, South Australia, Australia., Chen AF; Department of Orthopaedics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Coraça-Huber DC; Research Laboratory for Implant Associated Infections (Biofilm Lab), University Hospital for Orthopedics and Traumatology, Experimental Orthopaedics, Medical University of Innsbruck, Innsbruck, Austria., Dai T; Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Greenfield EM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indiana Center for Musculoskeletal Health, Indianapolis, Indiana, USA., Kasinath R; DePuy Synthes Biomaterials, Warsaw, Indiana, USA., Libera M; Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, New Jersey, USA., Marques CNH; Department of Biological Sciences, Binghamton Biofilm Research Center, Binghamton University, Binghamton, New York, USA., Moriarty TF; AO Research Institute Davos, Davos, Switzerland., Scott Phillips K; Laboratory of Analytical Chemistry, Division of Biological Standards and Quality Control, Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Raghuraman K; Enovis, Austin, Texas, USA., Ren D; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York, USA., Rimondini L; Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy., Saeed K; University Hospital Southampton NHS Foundation Trust, Winchester and Basingstoke, UK.; University of Southampton, Southampton, UK., Schaer TP; Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA., Schwarz EM; Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA., Spiegel C; Research Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Experimental Orthopedics, University Hospital for Orthopedics and Traumatology, Medical University of Innsbruck, Innsbruck, Austria., Stoodley P; Department Microbial Infection and Immunity and Department of Orthopaedics, The Ohio State University, Columbus, Ohio, USA., Truong VK; Biomedical Nanoengineering Laboratory, College of Medicine and Public Health, Bedford Park, South Australia, Australia., Tsang SJ; Department of Trauma and Orthopaedic Surgery, University of Edinburgh, Edinburgh, Scotland, UK., Wildemann B; Experimental Trauma Surgery, Department of Trauma, Hand and Reconstructive Surgery, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany., Zelmer AR; Centre for Orthopaedic and Trauma Research, University of Adelaide, Adelaide, South Australia, Australia., Zinkernagel AS; Department of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Mar; Vol. 42 (3), pp. 512-517. Date of Electronic Publication: 2024 Jan 12.

Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis.

Autor: Zelmer AR; Centre for Orthopaedic and Trauma Research, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia., Nelson R; Department of Infectious Diseases, Central Adelaide Local Health Network, Adelaide, SA, 5000, Australia.; Royal Adelaide Hospital, Adelaide, SA, 5000, Australia., Richter K; Richter Lab, Department of Surgery, Basil Hetzel Institute for Translational Health Research, University of Adelaide, Adelaide, SA, 5011, Australia., Atkins GJ; Centre for Orthopaedic and Trauma Research, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, 5000, Australia. gerald.atkins@adelaide.edu.au.

Publikováno v: Bone research [Bone Res] 2022 Aug 12; Vol. 10 (1), pp. 53. Date of Electronic Publication: 2022 Aug 12.

Evidence for osteocyte-mediated bone-matrix degradation associated with periprosthetic joint infection (PJI)

Autor: Ormsby RT, Zelmer AR, Yang D, Gunn NJ, Starczak Y, Kidd SP, Nelson R, Solomon LB, Atkins GJ

Publikováno v: European cells & materials [Eur Cell Mater] 2021 Oct 08; Vol. 42, pp. 264-280. Date of Electronic Publication: 2021 Oct 08.