In vivo engineered B cells retain memory and secrete high titers of anti-HIV antibodies in mice

Autor: Rina Rosin-Arbesfeld, Deli Huang, Shengdar Q. Tsai, Cicera R. Lazzarotto, James E. Voss, Nahmad Ad, Mary Tenuta, Zelikson N, Horovitz-Fried M, Iris Dotan, Adi Barzel, David Nemazee, Reuveni I, Talia Kustin, Adi Stern

As a potential single-shot HIV therapy, transplanted engineered B cells allow robust secretion of broadly neutralizing antibodies (bNAbs). However, ex vivo engineering of autologous B cells is expensive and requires specialized facilities, while allo

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https://doi.org/10.1101/2021.04.08.438900

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Striatin is a novel modulator of cell adhesion.

Autor: Lahav-Ariel L; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Caspi M; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Nadar-Ponniah PT; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Zelikson N; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Hofmann I; Division of Vascular Oncology and Metastasis, Center for Molecular Biology-German Cancer Research Center (DKFZ-ZMBH) Alliance, German Cancer Research Center, Heidelberg, Germany.; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Hanson KK; Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, USA; and., Franke WW; Helmholtz Group for Cell Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sklan EH; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Avraham KB; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Rosin-Arbesfeld R; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Apr; Vol. 33 (4), pp. 4729-4740. Date of Electronic Publication: 2018 Dec 28.