Identification of Small Molecules Affecting the Secretion of Therapeutic Antibodies with the Retention Using Selective Hook (RUSH) System

Autor: Mathilde Coulet, Sylvie Lachkar, Marion Leduc, Marc Trombe, Zelia Gouveia, Franck Perez, Oliver Kepp, Guido Kroemer, Stéphane Basmaciogullari

Publikováno v: Cells, Vol 12, Iss 12, p 1642 (2023)

Unlocking cell secretion capacity is of paramount interest for the pharmaceutical industry focused on biologics. Here, we leveraged retention using a selective hook (RUSH) system for the identification of human osteosarcoma U2OS cell secretion modula

Externí odkaz: https://doaj.org/article/4e8d2b8b7b4849619780f26877bc9c09

EXPERIMENTALLY-GENERATED GROUND TRUTH FOR DETECTING CELL TYPES IN AN IMAGE-BASED IMMUNOTHERAPY SCREEN

Autor: Franck Perez, Zelia Gouveia, Thomas Walter, Joseph Boyd

Publikováno v: 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI)
2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), Apr 2020, Iowa City, United States. pp.886-890, ⟨10.1109/ISBI45749.2020.9098696⟩
ISBI

International audience; Chimeric antigen receptor is an immunotherapy whereby T lympho-cytes are engineered to selectively attack cancer cells. Image-based screens of CART cells, combining phase contrast and fluorescence microscopy, suffer from the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96140865edeb3adf678e1c5a298eb51e
https://hal.archives-ouvertes.fr/hal-02976141