SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis

Autor: Yining Liu, Wei Zhang, Nan Lin, Zelei Yang, Yanxin Liu, Huaxia Chen

Publikováno v: Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-13 (2024)

Abstract Background Keloids are currently challenging to treat because they recur after resection which may affect patients’ quality of life. At present, no universal consensus on treatment regimen has been established. Thus, finding new molecular

Externí odkaz: https://doaj.org/article/4cb185f9dee54cccaf79777ec3fee2cd

Nationwide Outcomes following Percutaneous Cholecystostomy for Acute Calculous Cholecystitis and the Impact of Coronavirus Disease 2019: Results of the Multicentre Audit of Cholecystostomy and Further Interventions (MACAFI study)

Autor: Andrew MacCormick, Paul Jenkins, Jim Zhong, Gregory C. Makris, Nelofer Gafoor, David Chan, John Brittenden, David Stockell, Vinesh Palanimuthu, Yousef Shahin, Naomi Hersey, Thomas Geh, Joe Kang, Maria Sukhanenko, Zheng Dao Yin, Wei Sheng Pang, Dominic McGowan, Lokesh Saraswat, Nabil Ali, Usman Mahay, Katrina Harborne, Rahul Chivate, Romman Nourzaie, Niall Burke, Benedict Thomson, Gregory Makris, Christopher Clarke, Mehreen Yousuff, James Davies, John Sammut, Cherian George, Salman Javed Arain, Damian Mullan, Katherine Sophie Moore, Emile King, Zelei Yang, Chantal Liu, Alicia Skervin, Bankole Oyewole, Ajay Belgaumkar, Georgiana Zamfir, Matthew John Seager, Dinesh Madhavan Ramalingam Sethumadhavan, Praveen Peddu, Hunain Shiwani, Niaz Ahmed, Usman Goga, Mohammed Rashid Akthar, Arjun Bhondi, Fahad Mohammad, Can Hazar, Conor Aleman, Alex Hardman, James Murdoch, Mohamed Kasem, Syed Rahman, Edward Wigmore, Cameron Bullock, Andrew Gemmell, Omotolani Lewis, Joshua Lee, Sabrina Mason, Jun-Li Tham, Choong Leng Poon, Charlotte Jones, Ashley Thorpe, Vinay Kumar Doddaballapur, Tarryn Carlsson, Andrew White, Tonia Forjoe, Gaurav Sundar, A.J. Greenwood, Katherine Lewis, Karen Man Yan Chan, Amr Moussa, Kelvin Tan, Michael Crawford, Tariq Ali, Yasir Sabir, Amjad Chamsi Basha, Wing Yan Liu, Samuel Walker, Tze Hung Siah, Akash Ganguly, Mohammad Haroon Akram, Shian Patel, Drew Maclean, Harriet Williams-Gunn, Matthew O'Brien, Hannah Cliffe, Flavius Parvulescu, Joey Fong, Jins Kallampallil, Symeon Lechareas, Dexter Valencia, Pubudu Piyatissa, Robert Bakewell, Nicholas Heptonstall, Nadeem Shaida, Michael Ryder, Ketan Gaikwad, Vinay Gangadharan, Abubakar Habib, Gautam Menon, Abdishakur Mohamed, Jackson Pat, Nick Railton, Matthew Tam, Yong Keen Hor, Claire Ryan, Timothy Guest, Naeem Jagirdar, Madhurima R. Chetan, Faraaz Khan, Andrew MacDonald, Jim Zhong Kit Yeng Wong, Mahak Shah, Simon Burbidge, Mayooreshan Anandarajah

Publikováno v: Journal of vascular and interventional radiology : JVIR.

To assess the mortality, readmission rates, and practice variation of percutaneous cholecystostomy (PC) in patients with acute calculous cholecystitis in the United Kingdom (UK).A total of 1,186 consecutive patients (636 men [53.6%]; median age, 75 y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0a24251877e384eafe7c8ea5cfe9ed
https://pubmed.ncbi.nlm.nih.gov/36265818

Human Cytomegalovirus Seropositivity and Viral DNA in Breast Tumors Are Associated with Poor Patient Prognosis

Autor: Zelei Yang, Xiaoyun Tang, Maria Eloisa Hasing, Xiaoli Pang, Sunita Ghosh, Todd P. W. McMullen, David N. Brindley, Denise G. Hemmings

Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1148

Human cytomegalovirus (HCMV) infects 40–70% of adults in developed countries. Detection of HCMV DNA and/or proteins in breast tumors varies considerably, ranging from 0–100%. In this study, nested PCR to detect HCMV glycoprotein B (gB) DNA in bre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f113bf57d6fd92f91532807d76681264
https://doi.org/10.3390/cancers14051148

Lysophosphatidate Signaling: The Tumor Microenvironment’s New Nemesis

Autor: David N. Brindley, Xiaoyun Tang, Zelei Yang, Guanmin Meng, Matthew G.K. Benesch

Publikováno v: Trends in Cancer. 3:748-752

Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f104630adc19eaf16969ed9fb8222e
https://doi.org/10.1016/j.trecan.2017.09.004

Latent Cytomegalovirus Infection in Female Mice Increases Breast Cancer Metastasis

Autor: Guanmin Meng, Ana Paula Belon, Denise G. Hemmings, Jesus Serrano-Lomelin, David N. Brindley, Martina Mackova, Matthew G.K. Benesch, Zelei Yang, Xiaoyun Tang, Ing Swie Goping

Publikováno v: Cancers, Vol 11, Iss 4, p 447 (2019)
Cancers
Volume 11
Issue 4

Cytomegalovirus (CMV) infects 40&ndash
70% of women, but infection has been reported in >
95% of breast cancer patients. We investigated the consequences of these observations by infecting mice with mCMV or a negative control medium for 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feefb5114b71ff4726b006472c131b9
https://www.mdpi.com/2072-6694/11/4/447