Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Zelda R. Althaus"'
Publikováno v:
Developmental Pharmacology and Therapeutics. 7:319-333
The metabolism of radiolabeled cortisol and triamcinolone acetonide (TAC) was compared in the early, middle, and late gestational age rhesus monkeys. Trace amounts of 14C-cortisol and 10 mg/kg 3H-TAC (Kenalog) were simultaneously administered i.m. to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d776f10889c8c06b5a725f90ec7c2c8a
https://doi.org/10.1159/000457181
https://doi.org/10.1159/000457181
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 227:11-23
A high-performance liquid chromatography (HPLC) technique was developed for the determination of radiolabeled triamcinolone acetonide (TAC), cortisol and their metabolites in rhesus monkey plasma, urine and tissue samples. After protein precipitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5047c6e926d0daa402f7041cfcbec1e
https://doi.org/10.1016/s0378-4347(00)80351-5
https://doi.org/10.1016/s0378-4347(00)80351-5
Publikováno v:
Biochemical Pharmacology. 35:1389-1391
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90e569ba02a6a3a9a6a79d1afccb6c5
https://doi.org/10.1016/0006-2952(86)90286-8
https://doi.org/10.1016/0006-2952(86)90286-8
Publikováno v:
Cellular Biology and Pharmacology of the Placenta ISBN: 9781475719383
The oxidoreductase activity of 17β-hydroxysteroid dehydrogenase (17β-HSD) has been demonstrated in human placenta and catalyzes the interconversion of estradiol-17β (E2) and estrone (E1) (Langer and Engel, 1958; Jarabak and Sack, 1969; Strickler a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64def4215b8609ec44ec412d2cc8a499
https://doi.org/10.1007/978-1-4757-1936-9_33
https://doi.org/10.1007/978-1-4757-1936-9_33
Publikováno v:
Developmental pharmacology and therapeutics. 9(5)
The synthetic glucocorticoid dexamethasone (DEX) and endogenous cortisol were compared in 2 groups of pregnant monkeys of gestational age 143-148 days. In group I, a fetal intraplacental vein and a maternal femoral vessel were catheterized. 3H-Cortis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474354cc6926a5199bc18ba40d6df697
https://pubmed.ncbi.nlm.nih.gov/3780368
https://pubmed.ncbi.nlm.nih.gov/3780368
Publikováno v:
Toxicology and applied pharmacology. 67(1)
The distribution and metabolism of triamcinolone acetonide (TAC) in the rat embryomaternal unit were investigated during a teratogenically sensitive period. Pregnant rats (Day 12 of gestation) were injected im with 0.125 or 0.5 mg/kg [3H]TAC. Materna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03253da1ec26e5272fa599a783a72581
https://pubmed.ncbi.nlm.nih.gov/6845358
https://pubmed.ncbi.nlm.nih.gov/6845358
Metabolism of 17alpha-ethynylestradiol by intact liver parenchymal cells isolated from mouse and rat
Publikováno v:
Journal of toxicology and environmental health. 3(5-6)
Liver parenchymal cells isolated by perfusion from female C3H/HeN-MTV+Nctr mice and Sprague-Dawley rats were incubated with [6,7-3H] 17alpha-ethynylestradiol (EE2). The incubates were individually fractionated into free steroid (organic phase), stero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2a2dbaef535ae76cc39b3495bd900a
https://pubmed.ncbi.nlm.nih.gov/599590
https://pubmed.ncbi.nlm.nih.gov/599590
Publikováno v:
Teratology. 27(3)
Triamcinolone acetonide (TAC) is teratogenic in rats while cortisol has been reported as not teratogenic. The objective of this investigation was to determine whether this difference in teratogenicity could be due to a difference in the metabolism an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890514c309319a99865cd24974191903
https://pubmed.ncbi.nlm.nih.gov/6879456
https://pubmed.ncbi.nlm.nih.gov/6879456