Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Zekavat, SM"'
Autor:
Emdin, CA, Khera, AV, Natarajan, P, Klarin, D, Won, HH, Peloso, GM, Stitziel, NO, Nomura, A, Zekavat, SM, Bick, AG, Gupta, N, Asselta, R, Duga, S, Merlini, PA, Correa, A, Kessler, T, Wilson, JG, Bown, MJ, Hall, AS, Braund, PS, Samani, NJ, Schunkert, H, Marrugat, J, Elosua, R, McPherson, R, Farrall, M, Watkins, H, Willer, C, Abecasis, GR, Felix, JF, Vasan, RS, Lander, E, Rader, DJ, Danesh, J, Ardissino, D, Gabriel, S, Saleheen, D, Kathiresan, S, CHARGE–Heart Failure Consortium, CARDIoGRAM Exome Consortium
Publikováno v:
Journal of the American College of Cardiology, 68(25), 2761-2772. Elsevier Inc.
Background Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) levels has emerged as a therapeutic str
Autor:
Hathaway JT; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Shah MP; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Hathaway DB; Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts., Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston., Krasniqi D; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Gittinger JW Jr; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Cestari D; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Mallery R; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Abbasi B; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Bouffard M; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Chwalisz BK; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Estrela T; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston., Rizzo JF 3rd; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.; Neuro-Ophthalmology Service, Massachusetts Eye and Ear, Harvard Medical School, Boston.
Publikováno v:
JAMA ophthalmology [JAMA Ophthalmol] 2024 Aug 01; Vol. 142 (8), pp. 732-739.
Autor:
Rajasundaram S; Faculty of Medicine, Imperial College London, London, United Kingdom.; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States., Segrè AV; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Woolf B; School of Psychological Science, University of Bristol, Bristol, United Kingdom.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom., Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.; Yale University School of Medicine, New Haven, Connecticut, United States., Burgess S; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom., Khawaja AP; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom., Zebardast N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States., Wiggs JL; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.
Publikováno v:
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 Jul 01; Vol. 65 (8), pp. 35.
Autor:
Liu A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. liuaoxin@broadinstitute.org.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. liuaoxin@broadinstitute.org.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. liuaoxin@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. liuaoxin@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. liuaoxin@broadinstitute.org., Genovese G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. giulio@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. giulio@broadinstitute.org.; Department of Genetics, Harvard Medical School, Boston, MA, USA. giulio@broadinstitute.org., Zhao Y; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Pirinen M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland., Zekavat SM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Kentistou KA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Yang Z; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Yu K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Vlasschaert C; Department of Medicine, Queen's University, Kingston, Ontario, Canada., Liu X; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Brown DW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA., Hudjashov G; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Gorman BR; Center for Data and Computational Sciences (C-DACS), VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.; Booz Allen Hamilton, McLean, VA, USA., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Zhou W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Pyarajan S; Center for Data and Computational Sciences (C-DACS), VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tuzov V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Pajuste FD; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Aavikko M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Sipilä TP; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Ghazal A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Freedman ND; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Song L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Gardner EJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Sankaran VG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ollila HM; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Tukiainen T; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Natarajan P; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Daly MJ; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bick A; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., McCarroll SA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Loh PR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. poruloh@broadinstitute.org.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. poruloh@broadinstitute.org.; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. poruloh@broadinstitute.org., Ganna A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. andrea.ganna@helsinki.fi.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. andrea.ganna@helsinki.fi.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. andrea.ganna@helsinki.fi.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. andrea.ganna@helsinki.fi., Perry JRB; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. mitchell.machiela@nih.gov.
Publikováno v:
Nature [Nature] 2024 Jul; Vol. 631 (8019), pp. 134-141. Date of Electronic Publication: 2024 Jun 12.
Autor:
Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jorshery SD; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Rauscher FG; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany., Horn K; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany., Sekimitsu S; Tufts University School of Medicine, Boston, MA 02111, USA., Koyama S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Nguyen TT; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Costanzo MC; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jang D; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Burtt NP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kühnapfel A; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany., Shweikh Y; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Ye Y; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA., Raghu V; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zhao H; Computational Biology and Bioinformatics Program, Yale School of Medicine, New Haven, CT 06511, USA.; School of Public Health, Yale University, New Haven, CT 06510, USA., Ghassemi M; Departments of Computer Science/Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON M5G 1M1, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Elze T; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA., Segrè AV; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wiggs JL; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Del Priore L; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA., Scholz M; Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig University, Leipzig 04107, Germany.; Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig 04103, Germany., Wang JC; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT 06510, USA.; Northern California Retina Vitreous Associates, Mountain View, CA 94040, USA., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zebardast N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Publikováno v:
Science translational medicine [Sci Transl Med] 2024 Jan 24; Vol. 16 (731), pp. eadg4517. Date of Electronic Publication: 2024 Jan 24.
Autor:
Yu Z; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Fidler TP; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Ruan Y; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Vlasschaert C; Department of Medicine, Queen's University, Kingston, Ontario, Canada., Nakao T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Uddin MM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mack T; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Niroula A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden., Heimlich JB; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Zekavat SM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Ophthalmology, Massachusetts Eye and Ear Institute, Boston, Massachusetts, USA., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Heard-Costa N; Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Levy D; Framingham Heart Study, Framingham, Massachusetts, USA.; Division of Intramural Research, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA., Vasan RS; Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Libby P; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Jaiswal S; Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA., Ebert BL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Bick AG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Tall AR; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Publikováno v:
The Journal of clinical investigation [J Clin Invest] 2023 Sep 15; Vol. 133 (18). Date of Electronic Publication: 2023 Sep 15.
Autor:
Wong WJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Emdin C; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Bick AG; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Zekavat SM; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Yale University School of Medicine, New Haven, CT, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Niroula A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden., Pirruccello JP; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA., Dichtel L; Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Griffin G; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Uddin MM; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Kovalcik V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lin AE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., McConkey ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Vromman A; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sellar RS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Haematology, UCL Cancer Institute, London, UK., Kim PG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Agrawal M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weinstock J; Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Long MT; Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA., Yu B; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Banerjee R; Perspectum Ltd, Oxford, UK., Nicholls RC; Perspectum Ltd, Oxford, UK., Dennis A; Perspectum Ltd, Oxford, UK., Kelly M; Perspectum Ltd, Oxford, UK., Loh PR; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., McCarroll S; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Vasan RS; The University of Texas School of Public Health San Antonio, San Antonio, TX, USA.; Framingham Heart Study of the NHLBI and Boston University School of Medicine, Framingham, MA, USA.; The University of Texas Health Science Center, San Antonio, TX, USA., Jaiswal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Johnson AD; Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, MA, USA., Chung RT; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Corey K; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Levy D; Framingham Heart Study of the NHLBI and Boston University School of Medicine, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Ballantyne C; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Benjamin_Ebert@dfci.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu.; Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu., Natarajan P; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.
Publikováno v:
Nature [Nature] 2023 Jul; Vol. 619 (7970), pp. E47.
Autor:
Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jorshery SD; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departments of Computer Science/Medicine, University of Toronto, Toronto, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Shweikh Y; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Horn K; Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Germany and Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany., Rauscher FG; Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Germany and Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany., Sekimitsu S; Tufts University School of Medicine, Boston, MA, USA., Kayoma S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ye Y; Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA., Raghu V; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zhao H; Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.; School of Public Health, Yale University, New Haven, CT, USA., Ghassemi M; Departments of Computer Science/Medicine, University of Toronto, Toronto, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada.; Department of Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Elze T; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Segrè AV; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Wiggs JL; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Germany and Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Leipzig, Germany., Priore LD; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA., Wang JC; Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.; Northern California Retina Vitreous Associates, Mountain View, CA., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zebardast N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Publikováno v:
MedRxiv : the preprint server for health sciences [medRxiv] 2023 May 17. Date of Electronic Publication: 2023 May 17.
Autor:
Zekavat SM; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Sekimitsu S; Tufts University School of Medicine, Boston, Massachusetts., Doroodgar Jorshery S; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Computer Science, University of Toronto, Toronto, Canada; Computer Science and Electrical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Rossin EJ; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts., Del Priore L; Department of Ophthalmology, Yale School of Medicine, New Haven, Connecticut., Zebardast N; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts., Wang JC; Department of Ophthalmology, Yale School of Medicine, New Haven, Connecticut; Northern California Retina Vitreous Associates, Mountain View, California. Electronic address: jwang@ncrva.com.
Publikováno v:
Ophthalmology [Ophthalmology] 2023 Apr; Vol. 130 (4), pp. e15-e16. Date of Electronic Publication: 2023 Jan 25.
Autor:
Wong WJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Emdin C; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Bick AG; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Zekavat SM; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Yale University School of Medicine, New Haven, CT, USA.; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Niroula A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden., Pirruccello JP; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, University of California San Francisco, San Francisco, CA, USA., Dichtel L; Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Griffin G; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Uddin MM; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Kovalcik V; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lin AE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., McConkey ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Vromman A; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sellar RS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Haematology, UCL Cancer Institute, London, UK., Kim PG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Agrawal M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weinstock J; Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Long MT; Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA., Yu B; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Banerjee R; Perspectum Ltd, Oxford, UK., Nicholls RC; Perspectum Ltd, Oxford, UK., Dennis A; Perspectum Ltd, Oxford, UK., Kelly M; Perspectum Ltd, Oxford, UK., Loh PR; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., McCarroll S; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Vasan RS; The University of Texas School of Public Health San Antonio, San Antonio, TX, USA.; Framingham Heart Study of the NHLBI and Boston University School of Medicine, Framingham, MA, USA.; The University of Texas Health Science Center, San Antonio, TX, USA., Jaiswal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Johnson AD; Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, MA, USA., Chung RT; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Corey K; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Levy D; Framingham Heart Study of the NHLBI and Boston University School of Medicine, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Ballantyne C; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu.; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Benjamin_Ebert@dfci.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu.; Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu., Natarajan P; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.
Publikováno v:
Nature [Nature] 2023 Apr; Vol. 616 (7958), pp. 747-754. Date of Electronic Publication: 2023 Apr 12.