Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Zeji, Du"'
Autor:
Clara T. Nicolas, Caitlin J. VanLith, Raymond D. Hickey, Zeji Du, Lori G. Hillin, Rebekah M. Guthman, William J. Cao, Benjamin Haugo, Annika Lillegard, Diya Roy, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre Kocher, Robert A. Kaiser, Stephen J. Russell, Joseph B. Lillegard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Hereditary tyrosinemia type 1 (HT1) is an inborn error of metabolism caused by a deficiency in fumarylacetoacetate hydrolase (FAH). Here, the authors show in an animal model that HT1 can be treated via in vivo portal vein administration of a lentivir
Externí odkaz:
https://doaj.org/article/e139874638f64ab69e044b4aab48bfa5
Autor:
Clara T. Nicolas, Robert A. Kaiser, Raymond D. Hickey, Kari L. Allen, Zeji Du, Caitlin J. VanLith, Rebekah M. Guthman, Bruce Amiot, Lukkana Suksanpaisan, Bing Han, Maria Giovanna Francipane, Amin Cheikhi, Huailei Jiang, Aditya Bansal, Mukesh K. Pandey, Ishan Garg, Val Lowe, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre A. Kocher, Timothy R. DeGrado, Scott L. Nyberg, Eric Lagasse, Joseph B. Lillegard
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 738-750 (2020)
The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-
Externí odkaz:
https://doaj.org/article/8ffcb39c8aed4257acfa76228d16a408
Autor:
Raymond D. Hickey, Clara T. Nicolas, Kari Allen, Shennen Mao, Faysal Elgilani, Jaime Glorioso, Bruce Amiot, Caitlin VanLith, Rebekah Guthman, Zeji Du, Harvey Chen, Cary O. Harding, Robert A. Kaiser, Scott L. Nyberg, Joseph B. Lillegard
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Orthotopic liver transplantation remains the only curative therapy for inborn errors of metabolism. Given the tremendous success for primary immunodeficiencies using ex-vivo gene therapy with lentiviral vectors, there is great interest in developing
Externí odkaz:
https://doaj.org/article/28fa4edd0f0d436b83ea7d18ccf3489b
Autor:
Bruce Amiot, Timothy R. DeGrado, Amin Cheikhi, Caitlin J. VanLith, Val J. Lowe, Aditya Bansal, Robert A. Kaiser, Mukesh K. Pandey, Daniel R. O'Brien, Zeji Du, Huailei Jiang, Raymond D. Hickey, Rebekah M. Guthman, Lukkana Suksanpaisan, Scott L. Nyberg, Jean Pierre A. Kocher, Aditya Bhagwate, Ishan Garg, Maria Giovanna Francipane, Eric Lagasse, Clara T. Nicolas, Joseph B. Lillegard, Bing Han, Kari L. Allen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 738-750 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-
Publikováno v:
Energy & Fuels. 34:1791-1801
Artificial intelligence approach can be used to solve complicated process problems. A hybrid methodology comprising artificial neural network (ANN) and genetic algorithms (GA) was utilized to model...
Autor:
Clara T. Nicolas, Caitlin J. VanLith, Raymond D. Hickey, Zeji Du, Lori G. Hillin, Rebekah M. Guthman, William J. Cao, Benjamin Haugo, Annika Lillegard, Diya Roy, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre Kocher, Robert A. Kaiser, Stephen J. Russell, Joseph B. Lillegard
Publikováno v:
Nature communications. 13(1)
Conventional therapy for hereditary tyrosinemia type-1 (HT1) with 2-(2-nitro-4-trifluoromethylbenzoyl)−1,3-cyclohexanedione (NTBC) delays and in some cases fails to prevent disease progression to liver fibrosis, liver failure, and activation of tum
Publikováno v:
BioTechniques, Vol 35, Iss 1, Pp 66-72 (2003)
As a method for accurate quantitative and qualitative analysis of cell transcription, serial analysis of gene expression (SAGE) has been widely used in biological, medical, and pharmaceutical areas of research. The numerous steps required in the SAGE
Externí odkaz:
https://doaj.org/article/f42a0e2f2e3b487eaf7e11944cb37418
Autor:
Raymond D. Hickey, Kari L. Allen, Joseph B. Lillegard, Robert A. Kaiser, Zeji Du, Jennifer Anne Chilton, Clara T. Nicolas
Publikováno v:
Human Gene Therapy Clinical Development. 30:57-66
General safety and toxicology assessments supporting in vivo lentiviral vector-based therapeutic development are sparse. We have previously demonstrated the efficacy of a lentiviral vector expressi...
Autor:
Caitlin J. VanLith, Harvey S. Chen, Kari L. Allen, Faysal Elgilani, Scott L. Nyberg, Cary O. Harding, Raymond D. Hickey, Jaime Glorioso, Clara T. Nicolas, Zeji Du, Rebekah M. Guthman, Robert A. Kaiser, Joseph B. Lillegard, Shennen A. Mao, Bruce Amiot
Publikováno v:
Cell Transplantation
Cell Transplantation, Vol 28 (2019)
Cell Transplantation, Vol 28 (2019)
Orthotopic liver transplantation remains the only curative therapy for inborn errors of metabolism. Given the tremendous success for primary immunodeficiencies using ex-vivo gene therapy with lentiviral vectors, there is great interest in developing
Autor:
Kari L. Allen, Clara T. Nicolas, Rebekah M. Guthman, Zeji Du, Joseph B. Lillegard, Caitlin J. VanLith, Scott L. Nyberg, Raymond D. Hickey, Dong Jin Joo
Publikováno v:
Human Gene Therapy. 29:1315-1326
Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disorder caused by deficiency of fumarylacetoacetate hydrolase (FAH). It has been previously shown that ex vivo hepatocyte-directed gene therapy using an integrating lentiviral vector to r