Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture

Autor: Frühauf, Marie, Zeitschel, Ulrike, Höfling, Corinna, Ullm, Franziska, Rabiger, Friederike V., Alber, Gottfried, Pompe, Tilo, Müller, Uwe, Roßner, Steffen

Neurodegenerative disorders are characterised by the activation of brain-resident microglia cells and by the infiltration of peripheral T cells. However, their interplay in disease has not been clarified yet. It is difficult to investigate complex ce

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A93679
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Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer's disease

Autor: Hartlage-Rübsamen, Maike, Ratz, Veronika, Zeitschel, Ulrike, Finzel, Lukas, Machner, Lisa, Köppen, Janett, Schulze, Anja, Demuth, Hans-Ulrich, von Hörsten, Stephan, Höfling, Corinna, Roßner, Steffen

Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington's disease patients and HTT-transgenic animals. However, little is known about the physiological brain region- and

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A93869
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Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation

Autor: Schlenzig, Dagmar, Cynis, Holger, Hartlage-Rübsamen, Maike, Zeitschel, Ulrike, Menge, Katja, Fothe, Anja, Ramsbeck, Daniel, Spahn, Claudia, Wermann, Michael, Roßner, Steffen, Buchholz, Mirko, Schilling, Stephan, Demuth, Hans-Ulrich

The formation of amyloid-β (Aβ) peptides is causally involved in the development of Alzheimer’s disease (AD). A significant proportion of deposited Aβ is N-terminally truncated and modified at the N-terminus by a pGlu-residue (pGlu-Aβ). These f

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A94918
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Defined astrocytic expression of human amyloid precursorprotein in Tg2576 mouse brain

Autor: Heiland, Tina, Zeitschel, Ulrike, Puchades, Maja, Kuhn, Peer-Hendrik, Lichtenthaler, Stefan F., Bjaalie, Jan G., Hartlage-Rübsamen, Maike, Roßner, Steffen, Höfling, Corinna

Publikováno v: Heiland, Tina Zeitschel, Ulrike Puchades, Maja Kuhn, Peer-Hendrik Lichtenthaler, Stefan F. Bjaalie, Jan G. Hartlage-Rübsamen, Maike Roßner, Steffen Höfling, Corinna . Defined astrocytic expression of human amyloid precursorprotein in Tg2576 mouse brain. Glia. 2018, 67(67), 393-403
Glia

Externí odkaz: http://hdl.handle.net/10852/71997
https://www.duo.uio.no/bitstream/handle/10852/71997/1/Heiland_et_al-2019-Glia.pdf