High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity.

Autor: Lee S; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Weiss T; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Bühler M; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Mena J; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Lottenbach Z; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Wegmann R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Sun M; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Bihl M; Institute of Pathology, University Hospital Zurich, Zurich, Switzerland., Augustynek B; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Bern, Switzerland.; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland., Baumann SP; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Bern, Switzerland., Goetze S; Department of Health Sciences and Technology, Institute of Translational Medicine (ITM), ETH Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH PHRT Swiss Multi-Omics Center (SMOC), Zurich, Switzerland., van Drogen A; Department of Health Sciences and Technology, Institute of Translational Medicine (ITM), ETH Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH PHRT Swiss Multi-Omics Center (SMOC), Zurich, Switzerland., Pedrioli PGA; Department of Health Sciences and Technology, Institute of Translational Medicine (ITM), ETH Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH PHRT Swiss Multi-Omics Center (SMOC), Zurich, Switzerland., Penton D; Electrophysiology Facility, University of Zurich, Zurich, Switzerland., Festl Y; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland., Buck A; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Kirschenbaum D; Department of Neuropathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Zeitlberger AM; Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Neidert MC; Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Vasella F; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland., Rushing EJ; Department of Neuropathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Wollscheid B; Department of Health Sciences and Technology, Institute of Translational Medicine (ITM), ETH Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH PHRT Swiss Multi-Omics Center (SMOC), Zurich, Switzerland., Hediger MA; Membrane Transport Discovery Lab, Department of Nephrology and Hypertension and Department of Biomedical Research, Inselspital, University of Bern, Bern, Switzerland., Weller M; Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, University Hospital Zurich, Zurich, Switzerland., Snijder B; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. bsnijder@ethz.ch.; Swiss Institute of Bioinformatics, Lausanne, Switzerland. bsnijder@ethz.ch.; Comprehensive Cancer Center Zurich, University Hospital Zurich, Zurich, Switzerland. bsnijder@ethz.ch.

Publikováno v: Nature medicine [Nat Med] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.

Multiple craniotomies in patients with brain metastases: a two-center, propensity score-matched study.

Autor: Padevit L; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Zeitlberger AM; Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Maldaner N; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Sarnthein J; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Bozinov O; Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Regli L; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Neidert MC; Department of Neurosurgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Serra C; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Voglis S; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland. stefanos.voglis@usz.ch.

Publikováno v: Neurosurgical review [Neurosurg Rev] 2024 Jul 26; Vol. 47 (1), pp. 354. Date of Electronic Publication: 2024 Jul 26.

A T-cell antigen atlas for meningioma: novel options for immunotherapy.

Autor: Medici G; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland. gioele.medici@usz.ch.; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland. gioele.medici@usz.ch., Freudenmann LK; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; DKFZ Partner Site Tübingen, German Cancer Consortium (DKTK), Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Velz J; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland., Wang SS; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.; Department of Neurosurgery and Neurotechnology, Eberhard Karls University Tübingen, Tübingen, Germany., Kapolou K; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Paramasivam N; Computational Oncology Group, Molecular Precision Oncology Program, NCT Heidelberg and DKFZ, Heidelberg, Germany., Mühlenbruch L; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Peptide-Based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany., Kowalewski DJ; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; DKFZ Partner Site Tübingen, German Cancer Consortium (DKTK), Tübingen, Germany., Vasella F; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland., Bilich T; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA., Frey BM; Blood Transfusion Service, Swiss Red Cross, Schlieren, Switzerland., Dubbelaar ML; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Peptide-Based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany.; Quantitative Biology Center (QBiC), Eberhard Karls University Tübingen, 72076, Tübingen, Baden-Württemberg, Germany., Patterson AB; Institute of Immunobiology, Cantonal Hospital St.Gallen, 9007, St. Gallen, Switzerland., Zeitlberger AM; Department of Neurosurgery, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland., Silginer M; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland., Roth P; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland., Weiss T; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland., Wirsching HG; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland., Krayenbühl N; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland., Bozinov O; Department of Neurosurgery, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland., Regli L; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland., Rammensee HG; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; DKFZ Partner Site Tübingen, German Cancer Consortium (DKTK), Tübingen, Germany., Rushing EJ; Department of Neuropathology, University Hospital and University of Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland., Sahm F; Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Walz JS; Institute for Cell Biology, Department of Immunology, University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Peptide-Based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany.; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Weller M; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland., Neidert MC; Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.; Department of Neurosurgery, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, 9007, St. Gallen, Switzerland.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2023 Aug; Vol. 146 (2), pp. 173-190. Date of Electronic Publication: 2023 Jun 27.

Association of pre- and postoperative αKlotho levels with long-term remission after pituitary surgery for acromegaly.

Autor: Neidert MC; Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland. marian.neidert@kssg.ch.; Department of Neurosurgery, Kantonsspital St.Gallen, Rohrschacher Strasse 95, 9007, St. Gallen, Switzerland. marian.neidert@kssg.ch., Zeitlberger AM; Department of Neurosurgery, Kantonsspital St.Gallen, Rohrschacher Strasse 95, 9007, St. Gallen, Switzerland., Leske H; Department of Neuropathology, University Hospital Zurich, Zurich, Switzerland.; Department of Pathology, Oslo University Hospital, Oslo, Norway.; University of Oslo (UiO), Oslo, Norway., Tschopp O; Division of Endocrinology and Diabetes, University Hospital Zurich, Zurich, Switzerland., Sze L; Division of Endocrinology and Diabetes, Kantonsspital Winterthur, Winterthur, Switzerland., Zwimpfer C; Division of Endocrinology and Diabetes, University Hospital Zurich, Zurich, Switzerland., Wiesli P; Department of Internal Medicine, Kantonsspital Frauenfeld, Frauenfeld, Switzerland., Bellut D; Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland., Bernays RL; Department of Neurosurgery, Clinic Hirslanden, Zurich, Switzerland., Rushing EJ; Department of Neuropathology, University Hospital Zurich, Zurich, Switzerland., Schmid C; Division of Endocrinology and Diabetes, University Hospital Zurich, Zurich, Switzerland.

Publikováno v: Scientific reports [Sci Rep] 2022 Aug 30; Vol. 12 (1), pp. 14765. Date of Electronic Publication: 2022 Aug 30.

Gender disparity in neurosurgery: A multinational survey on gender-related career satisfaction.

Autor: Zeitlberger AM; Department of Neurosurgery, Kantonsspital St.Gallen, St.Gallen, Switzerland., Baticam NS; Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland., Sprenger L; Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland., Tizi K; Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland., Schaller K; Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland.; Faculty of Medicine, University of Geneva, Geneva, Switzerland., Stienen MN; Department of Neurosurgery, Kantonsspital St.Gallen, St.Gallen, Switzerland.

Publikováno v: Brain & spine [Brain Spine] 2022 May 06; Vol. 2, pp. 100890. Date of Electronic Publication: 2022 May 06 (Print Publication: 2022).