Hydrolysis of glycosyl thioimidates by glycoside hydrolase requires remote activation for efficient activity

Autor: Zeinab Assaf, Salvatore G. Pistorio, Laure Guillotin, Richard Daniellou, Alexei V. Demchenko, Pierre Lafite

Publikováno v: Catalysts
Catalysts, MDPI, 2019, 9 (10), pp.826. ⟨10.3390/catal9100826⟩
Catalysts, 2019, 9 (10), pp.826. ⟨10.3390/catal9100826⟩
Volume 9
Issue 10
Catalysts, Vol 9, Iss 10, p 826 (2019)

International audience; Chemoenzymatic synthesis of glycosides relies on efficient glycosyl donor substrates able to react rapidly and efficiently, yet with increased stability towards chemical or enzymatic hydrolysis. In this context, glycosyl thioi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5799e38ed67b1b2d4bdfb44dcc7ab95
https://hal-univ-orleans.archives-ouvertes.fr/hal-03478291/document

Chemoenzymatic Synthesis of New 2,4-syn-Functionalized (S)-Glutamate Analogues and Structure–Activity Relationship Studies at Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

Autor: Darryl S. Pickering, Thierry Gefflaut, Birgitte Nielsen, Jette S. Kastrup, Michael Gajhede, Raminta Venskutonytė, Bjarke Abrahamsen, Zeinab Assaf, Karla Frydenvang, Anders A. Jensen, Lennart Bunch, Liwei Han, Anja Probst Larsen

Publikováno v: Journal of Medicinal Chemistry. 56:1614-1628

In the mammalian central nervous system, (S)-glutamate (Glu) is released from the presynaptic neuron where it activates a plethora of pre- and postsynaptic Glu receptors. The fast acting ionotropic Glu receptors (iGluRs) are ligand gated ion channels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9440fb05de9eecd85a4a7d9926bb46e0
https://doi.org/10.1021/jm301433m

Fructose-1,6-Bisphosphate Aldolase-Mediated Synthesis of Aminocyclitols (Analogues of Valiolamine) and their Evaluation as Glycosidase Inhibitors

Autor: Zeinab Assaf, H. Veschambre, Flora Camps Bres, Jean Bolte, Lahssen El Blidi, Marielle Lemaire, Vincent Théry

Publikováno v: ChemCatChem. 1:463-471

A highly stereoselective method for the preparation of nitro- and aminocyclitols, using fructose-1,6-bisphosphate aldolase, which catalyzes the aldol reaction of dihydroxyacetone phosphate (DHAP) on hydroxynitrobutanals, is reported. The key part of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40c97a4233acaaab0f99dfdeb3cda3a7
https://doi.org/10.1002/cctc.200900151

A 'click' chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins

Autor: Xinjun Liu, Otmane Lamrabet, Yang Wang, Cheng-Cai Zhang, Fabio Ziarelli, Gilles Quéléver, Fanqi Qu, Amel Latifi, Zeinab Assaf, Ling Peng

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (33), pp.6470-6475. ⟨10.1039/c4ob01005a⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2014, 12 (33), pp.6470-6475. ⟨10.1039/c4ob01005a⟩

An ingenious and specific affinity resin designed to capture the 2-oxoglutaric acid (2-OG) binding proteins was constructed by appending a 2-OG tag to the solid resin via a Cu-catalyzed Huisgen "click" reaction. The so-obtained affinity resin was abl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dff877cb889d543644663f5d15caa8
https://pubmed.ncbi.nlm.nih.gov/25019277

Preparation of Glutamate Analogues by Enzymatic Transamination

Autor: Martine Sancelme, Thierry Gefflaut, Zeinab Assaf

Publikováno v: Methods in Molecular Biology ISBN: 9781617793301

Aminotransferases are key enzymes of the metabolism of proteinogenic amino acids. These ubiquitous biocatalysts show high specific activities and relaxed substrate specificities making them valuable tools for the stereoselective synthesis of unnatura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d57360484e5355bd441904e352cd0a3
https://doi.org/10.1007/978-1-61779-331-8_4