Výsledky vyhledávání - "Zeinab Abdel-All"

Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein

Autor: Elizabeta B. Mukaetova-Ladinska, Charlotte Graham, Estibaliz Santiago-Mugica, Rajesh N. Kalaria, Mosi Li, Richard J. Q. McNally, Zeinab Abdel-All

Publikováno v: Journal of Alzheimer's Disease. 71:569-580

Background Discovering biomarkers for dementia is a pivotal step toward successful early diagnosis and treatment. Although plasma biomarkers have been explored, no consensus has been reached. Alpha-synuclein (AS), a 14 kDa synaptic protein associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4ab75b23eca06fc5f455afed9c8821
https://doi.org/10.3233/jad-190567

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Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study

Autor: John T. O'Brien, Joana Andrade, Elizabeta B. Mukaetova-Ladinska, Raj N. Kalaria, Zeinab Abdel-All, Joaquim Alves da Silva

Publikováno v: International Journal of Geriatric Psychiatry. 30:368-375

Background Clusterin protein in plasma has been found to differentiate between people with and without cognitive changes. However, these findings are not conclusive, despite the clusterin gene variations repeatedly being linked to increased risk for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bef6fca27ffa9f026360c8c12bae90a
https://doi.org/10.1002/gps.4145

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Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study

Autor: Joana Andrade, Joaquim Alves da Silva, Zeinab Abdel-All, Steven Dodds, John T. O'Brien, Elizabeta B. Mukaetova-Ladinska, Raj N. Kalaria

Publikováno v: Age and Ageing. 41:408-412

Background: the diagnosis of dementia, in particular Alzheimer’s disease (AD), is enhanced with the use of molecular biomarkers. Since cerebrospinal fluid analysis and molecular neuroimaging are not routinely used in many countries, blood biomarker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bae88c297f100ff63c3c6372b400309
https://doi.org/10.1093/ageing/afr171

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Alpha- and Gamma-Synuclein Proteins Are Present in Cerebrospinal Fluid and Are Increased in Aged Subjects with Neurodegenerative and Vascular Changes

Autor: Jeanette Doherty, G McIntosh, I Milton, Alina Andras, Elizabeta B. Mukaetova-Ladinska, J. Robson, Ian G. McKeith, Evelyn Jaros, E Greally, J Milne, John H. Xuereb, Robert H. Perry, Zeinab Abdel-All, Carol Brayne, Andrea Cleghorn, Joaquim Cerejeira

Publikováno v: Dementia and Geriatric Cognitive Disorders. 26:32-42

Background: Disease-specific biomarkers should reflect a fundamental feature of neuropathology and be validated in neuropathologically confirmed cases. Several synaptic proteins have been described in cerebrospinal fluid (CSF) of patients with dement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91bdf21daef8e0569db91bc7770161d
https://doi.org/10.1159/000141039

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Tau proteins in the temporal and frontal cortices in patients with vascular dementia

Autor: Arthur E. Oakley, Mosi Li, Lucy J. L. Craggs, Raj N. Kalaria, Zeinab Abdel-All, William G. Honer, Elizabeta B. Mukaetova-Ladinska, Estibaliz Santiago Mugica

Publikováno v: Journal of neuropathology and experimental neurology. 74(2)

We previously reported that, in the brains of older patients with vascular dementia (VaD), there is a distinctive accumulation of detergent-extractable soluble amyloid-β, with a predominance of Aβ42 species. It is unclear, however, if tau proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a0ea33b1cbdc6db4d39cd1dde3dfa6
https://pubmed.ncbi.nlm.nih.gov/25575131

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Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies

Autor: Joan Milne, William G. Honer, Andrea Cleghorn, Elaine K. Perry, Raj N. Kalaria, Evelyn Jaros, Alina Andras, Robert H. Perry, Zeinab Abdel-All, Elizabeta B. Mukaetova-Ladinska, Gary McIntosh, Ian G. McKeith, Iwo Borr, Jeanette Doherty

Publikováno v: Journal of neuropathology and experimental neurology. 72(1)

Functional neuroimaging studies have consistently reported abnormalities in the visual cortex in patients with dementia with Lewy bodies (DLB), but their neuropathologic substrates are poorly understood. We analyzed synaptic proteins and choline acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ba54760985bc02f401a8013d5783b4
https://pubmed.ncbi.nlm.nih.gov/23242284

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Increase in platelet immunoglobulin in Alzheimer's disease is normalised following cholinesterase inhibitor treatment: preliminary results

Autor: John T. O'Brien, Peter W. James, Elizabeta B. Mukaetova-Ladinska, Richard J. Q. McNally, Zeinab Abdel-All, Raj N. Kalaria, Joana Andrade

Publikováno v: Journal of Alzheimer's disease : JAD. 32(2)

We report a 16.5% increase in platelet immunoglobulin (Ig) content in subjects with Alzheimer's disease (AD) in relation to cognitively intact individuals (p = 0.021), whereas the plasma Ig levels were unaltered (p = 0.428). The upregulation of plate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c031e9aea32e9829a2dd95691c3424b
https://pubmed.ncbi.nlm.nih.gov/22810090

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Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals

Autor: E. C. Downes, Zeinab Abdel-All, John H. Xuereb, Carol Brayne, Elizabeta B. Mukaetova-Ladinska, E. Grailly, Anthony J. Holland, J. Robson, William G. Honer

Publikováno v: Neuropathology and applied neurobiology. 34(1)

AIMS This study quantified the density of the synaptic proteins synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in brains from elderly Down's syndrome individuals. METHODS Six areas (frontal, occipital, parietal and temporal lobes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52300450275bca4fb30bc1bd97a9f89
https://pubmed.ncbi.nlm.nih.gov/18005332

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Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement

Autor: Andrew M. Schaefer, D.M. Turnbull, Joanne Betts, Evelyn Jaros, Robert H. Perry, Zeinab Abdel-All, Robert N. Lightowlers, Robert W. Taylor

Publikováno v: Neuropathology and applied neurobiology. 32(4)

Mitochondrial DNA (mtDNA) disease is an important genetic cause of neurological disability. A variety of different clinical features are observed and one of the most common phenotypes is MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e01bd6aa97c7635d58342258929271
https://pubmed.ncbi.nlm.nih.gov/16866982

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