Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zeina Kais"'
Autor:
Jeffrey D. Parvin, Kun Huang, Charles L. Shapiro, Robert T. Pilarski, Gang He, Derek J.R. Ransburgh, Alicia Zha, Haritha Mathsyaraja, Sanford H. Barsky, Zeina Kais
To find genes and proteins that collaborate with BRCA1 or BRCA2 in the pathogenesis of breast cancer, we used an informatics approach and found a candidate BRCA interactor, KIAA0101, to function like BRCA1 in exerting a powerful control over centroso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a568c8afe723d12f0f9ec1960b6ee89
https://doi.org/10.1158/1541-7786.c.6542176
https://doi.org/10.1158/1541-7786.c.6542176
Autor:
Jeffrey D. Parvin, Kun Huang, Charles L. Shapiro, Robert T. Pilarski, Gang He, Derek J.R. Ransburgh, Alicia Zha, Haritha Mathsyaraja, Sanford H. Barsky, Zeina Kais
PDF file - 2651K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e50a3f394e69f0596c79e26e802983a
https://doi.org/10.1158/1541-7786.22518904.v1
https://doi.org/10.1158/1541-7786.22518904.v1
Autor:
Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O’Leary, David Kozono, Alan D. D’Andrea, Raphael Ceccaldi
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2488-2499 (2016)
BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity through replication fork stabilization. Loss of BRCA1/2 proteins results in DNA repair defici
Externí odkaz:
https://doaj.org/article/141f993ac6784bf3b60e216a37c7558b
Autor:
Jie Zhang, Kewei Lu, Yang Xiang, Muhtadi Islam, Shweta Kotian, Zeina Kais, Cindy Lee, Mansi Arora, Hui-Wen Liu, Jeffrey D Parvin, Kun Huang
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002656 (2012)
Gene co-expression network analysis is an effective method for predicting gene functions and disease biomarkers. However, few studies have systematically identified co-expressed genes involved in the molecular origin and development of various types
Externí odkaz:
https://doaj.org/article/8e538ade19134298862ed292dd2f3ec7
Autor:
Colin O’Leary, Raphael Ceccaldi, Zeina Kais, Beatrice Rondinelli, David Kozono, Alan D. D'Andrea, Amie Holmes
Publikováno v:
Cell Reports
Cell Reports, Vol 15, Iss 11, Pp 2488-2499 (2016)
Cell Reports, Vol 15, Iss 11, Pp 2488-2499 (2016)
SummaryBRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity through replication fork stabilization. Loss of BRCA1/2 proteins results in DNA repair
Publikováno v:
Oncogene. 31:799-804
We analyzed the effects of 14 different missense mutations in the RING domain of BRCA1 on the function of the protein in the control of centrosome number in tissue culture cells. Whereas 2 of the 14 BRCA1 variant proteins were neutral in the centroso
Autor:
Hui Wen Liu, Zeina Kais, Shweta Kotian, Jeffrey D. Parvin, Kun Huang, Kewei Lu, Mansi Arora, Cindy Lee, Yang Xiang, Jie Zhang, Muhtadi M. Islam
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 8, Iss 8, p e1002656 (2012)
PLoS Computational Biology, Vol 8, Iss 8, p e1002656 (2012)
Gene co-expression network analysis is an effective method for predicting gene functions and disease biomarkers. However, few studies have systematically identified co-expressed genes involved in the molecular origin and development of various types
Autor:
Zeina Kais, Jeffrey D. Parvin
Publikováno v:
The Centrosome ISBN: 9781627030342
Chromosomal instability and aneuploidy are commonly observed in breast tumor cells. Loss of function of the breast- and ovarian-specific tumor suppressor gene, BRCA1, results in supernumerary centrosomes that are likely to contribute to the genetic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1af829227c3b20588f0c0e76899630d
https://doi.org/10.1007/978-1-62703-035-9_14
https://doi.org/10.1007/978-1-62703-035-9_14
Autor:
Gang He, Haritha Mathsyaraja, Zeina Kais, Charles L. Shapiro, Robert Pilarski, Kun Huang, Alicia Zha, Sanford H. Barsky, Derek J.R. Ransburgh, Jeffrey D. Parvin
To find genes and proteins that collaborate with BRCA1 or BRCA2 in the pathogenesis of breast cancer, we used an informatics approach and found a candidate BRCA interactor, KIAA0101, to function like BRCA1 in exerting a powerful control over centroso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aec831d8cb35a3ec01e99b48b05d1e
https://europepmc.org/articles/PMC3157549/
https://europepmc.org/articles/PMC3157549/
Autor:
Mansi Arora, Shweta Kotian, Alicia Zha, Ümit V. Çatalyürek, Jeffrey D. Parvin, Kun Huang, Zeina Kais, Derek J.R. Ransburgh, Doruk Bozdağ
Publikováno v:
2009 Ohio Collaborative Conference on Bioinformatics.
We are developing a new framework for discovery of genes involved in the breast carcinogenesis process. Among families that have a predisposition to breast cancer, approximately 25% have inherited mutations in either breast cancer associated (“BRCA