A RAC-GEF network critical for early intestinal tumourigenesis

Autor: Jim Cassidy, Owen J. Sansom, William C. Clark, Luis Serrano, Volker M. Stucke, Martin J Drysdale, Martin R Turner, Arafath Kaja Najumudeen, R.P. Fordham, Karen Pickering, Lucas B. Zeiger, Ewan J. McGhee, Saskia M. Brachmann, Ann Hedley, Andrew D. Campbell, Kathryn Gilroy, Jeanette A. Johansson, Maureen M. Bain, David F. Vincent, Kevin Myant, Christina Kiel, Kurt I. Anderson, Benjamin LeRoy Miller, Angeliki Malliri, S.R. van Hoof, Sigrid K. Fey, Jan Paul Medema, E.B. Unal, Anna-Karin E. Johnsson, Catherine Nixon, Laura M. Machesky, Douglas Strathdee

Publikováno v: Nature communications, 12(1):56. Nature Publishing Group
Nature Communications
Pickering, KA, Gilroy, K, Cassidy, JW, Fey, SK, Najumudeen, AK, Zeiger, LB, Vincent, DF, Gay, DM, Johansson, J, Fordham, RP, Miller, B, Clark, W, Hedley, A, Unal, EB, Kiel, C, McGhee, E, Macheskey, LM, Nixon, C, Johnsson, AE, Bain, M, Strathdee, D, van Hoof, SR, Medema, JP, Anderson, KI, Brachmann, SM, Stucke, VM, Malliri, A, Drysdale, M, Turner, M, Serrano, L, Myant, K B, Campbell, AD & Sansom, OJ 2021, ' A RAC-GEF network critical for early intestinal tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-020-20255-4
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
University of Edinburgh-PURE

RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we reasoned that indirect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a4588ea791829c408931197ab3e425
https://pure.amc.nl/en/publications/a-racgef-network-critical-for-early-intestinal-tumourigenesis(1d3b7cc2-5483-46a6-accd-e659022a288b).html

Implications of Peak Selection in the Interpretation of Unsupervised Mass Spectrometry Imaging Data Analyses.

Autor: Murta T; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Steven RT; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Nikula CJ; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Thomas SA; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Zeiger LB; Cancer Research UK Beatson Institute, Glasgow G61 1BD, U.K.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, U.K., Dexter A; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Elia EA; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Yan B; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K., Campbell AD; Cancer Research UK Beatson Institute, Glasgow G61 1BD, U.K., Goodwin RJA; Imaging and AI, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, U.K.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K., Takáts Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, U.K., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow G61 1BD, U.K.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, U.K., Bunch J; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0WL, U.K.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, U.K.; The Rosalind Franklin Institute, Oxfordshire OX11 0FA, U.K.

Publikováno v: Analytical chemistry [Anal Chem] 2021 Feb 02; Vol. 93 (4), pp. 2309-2316. Date of Electronic Publication: 2021 Jan 04.

The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development.

Autor: Demetz E; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Tymoszuk P; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Hilbe R; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Volani C; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Haschka D; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Heim C; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Auer K; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Lener D; Department of Internal Medicine III, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Zeiger LB; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Pfeifhofer-Obermair C; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Boehm A; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Obermair GJ; Department of Physiology and Medical Physics, Medical University of Innsbruck, Fritz-Pregl-Straße 3, 6020 Innsbruck, Austria.; Division of Physiology, Karl Landsteiner University of Health Sciences, Dr.-Karl-Dorrek-Straße 30, 3500 Krems, Austria., Ablinger C; Department of Physiology and Medical Physics, Medical University of Innsbruck, Fritz-Pregl-Straße 3, 6020 Innsbruck, Austria., Coassin S; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Schöpfstraße 41, 6020 Innsbruck, Austria., Lamina C; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Schöpfstraße 41, 6020 Innsbruck, Austria., Kager J; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Petzer V; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Asshoff M; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Schroll A; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Nairz M; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Dichtl S; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Seifert M; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.; Christian Doppler Laboratory for Iron Metabolism and Anemia Research, Medical University of Innsbruck, Innsbruck, Austria., von Raffay L; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Fischer C; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Barros-Pinkelnig M; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Brigo N; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Valente de Souza L; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.; Christian Doppler Laboratory for Iron Metabolism and Anemia Research, Medical University of Innsbruck, Innsbruck, Austria., Sopper S; Department of Internal Medicine V, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Hirsch J; Department of Cardiac Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Graber M; Department of Cardiac Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Gollmann-Tepeköylü C; Department of Cardiac Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Holfeld J; Department of Cardiac Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Halper J; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Macheiner S; Department of Internal Medicine I, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Gostner J; Division of Medical Biochemistry, Medical University of Innsbruck, Innrain 80/IV, 6020 Innsbruck, Austria., Vogel GF; Department of Pediatrics I, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Pechlaner R; Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Moser P; Department of Pathology, Innsbruck University Hospital, Anichstraße 35, 6020 Innsbruck, Austria., Imboden M; Swiss Tropical and Public Health Institute, Socinstraße 57, 4051 Basel, Switzerland.; Department of Public Health, University of Basel, Bernoullistraße 28, 4056 Basel, Switzerland., Marques-Vidal P; Department of Internal Medicine, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne, Switzerland., Probst-Hensch NM; Swiss Tropical and Public Health Institute, Socinstraße 57, 4051 Basel, Switzerland.; Department of Public Health, University of Basel, Bernoullistraße 28, 4056 Basel, Switzerland., Meiselbach H; Department of Nephrology and Hypertension, University Hospital Erlangen, Maximiliansplatz 2, 91054 Erlangen, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Marchioninistraße 15, 81377 Munich, Germany., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.; German Center for Diabetes Research, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.; German Center for Cardiovascular Research, Lazarettstraße 36, 80636 Munich, Germany., Paulweber B; First Department of Medicine, Paracelsus Medical University Salzburg, Strubergasse 21, 5020 Salzburg, Austria., Willeit J; Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Kiechl S; Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Kronenberg F; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Schöpfstraße 41, 6020 Innsbruck, Austria., Theurl I; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Tancevski I; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria., Weiss G; Department of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.; Christian Doppler Laboratory for Iron Metabolism and Anemia Research, Medical University of Innsbruck, Innsbruck, Austria.

Publikováno v: European heart journal [Eur Heart J] 2020 Oct 21; Vol. 41 (40), pp. 3949-3959.