Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Zehava Eichenbaum"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT In the presence of molecular oxygen, the human pathogen Streptococcus pneumoniae produces and secretes large amounts of hydrogen peroxide (H2O2), which can readily interact with free and heme-bound iron. Here, we investigated the role of the
Externí odkaz:
https://doaj.org/article/7634731fffc5452ebc78114914effc28
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Group A Streptococcus (GAS) is a major pathogen that causes simple and invasive infections. GAS requires iron for metabolic processes and pathogenesis, and heme is its preferred iron source. We previously described the iron-regulated hupZ in GAS, sho
Externí odkaz:
https://doaj.org/article/6a9ff122c3444841acb8a05d6e8a2f7a
Autor:
Erin McDevitt, Faidad Khan, Anna Scasny, Courtney D. Thompson, Zehava Eichenbaum, Larry S. McDaniel, Jorge E. Vidal
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT Streptococcus pneumoniae and other streptococci produce a greenish halo on blood agar plates referred to as alpha-hemolysis. This phenotype is utilized by clinical microbiology laboratories to report culture findings of alpha-hemolytic strep
Externí odkaz:
https://doaj.org/article/56f84435c9c14458b2d0761f05ba9ed0
Autor:
Laura C. C. Cook, Nilanjana Chatterjee, Yan Li, Jorge Andrade, Michael J. Federle, Zehava Eichenbaum
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Streptococcus pyogenes (group A streptococcus [GAS]) is a serious human pathogen with the ability to colonize mucosal surfaces such as the nasopharynx and vaginal tract, often leading to infections such as pharyngitis and vulvovaginitis. We
Externí odkaz:
https://doaj.org/article/c6d79089914746b8b2256d0f0e6bd126
Autor:
Ephrahime S. Traore, Jiasong Li, Tapiwa Chiura, Jiafeng Geng, Ankita J. Sachla, Francis Yoshimoto, Zehava Eichenbaum, Ian Davis, Piotr J. Mak, Aimin Liu
Publikováno v:
Molecules, Vol 26, Iss 3, p 549 (2021)
HupZ is an expected heme degrading enzyme in the heme acquisition and utilization pathway in Group A Streptococcus. The isolated HupZ protein containing a C-terminal V5-His6 tag exhibits a weak heme degradation activity. Here, we revisited and charac
Externí odkaz:
https://doaj.org/article/48e33a0209c94d188c758fdbce52962e
From Host Heme To Iron: The Expanding Spectrum of Heme Degrading Enzymes Used by Pathogenic Bacteria
Autor:
Kristin V. Lyles, Zehava Eichenbaum
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Iron is an essential nutrient for many bacteria. Since the metal is highly sequestered in host tissues, bound predominantly to heme, pathogenic bacteria often take advantage of heme uptake and degradation mechanisms to acquire iron during infection.
Externí odkaz:
https://doaj.org/article/9b8b8be9ec3943aa8e1b714ded4cbdd5
Autor:
Bingchen Yu, Manjusha Roy Choudhury, Xiaoxiao Yang, Stéphane L. Benoit, Edroyal Womack, Kristin Van Mouwerik Lyles, Atanu Acharya, Arvind Kumar, Ce Yang, Anna Pavlova, Mengyuan Zhu, Zhengnan Yuan, James C. Gumbart, David W. Boykin, Robert J. Maier, Zehava Eichenbaum, Binghe Wang
Publikováno v:
ACS Infectious Diseases. 8:1491-1508
The rapid and persistent emergence of drug-resistant bacteria poses a looming public health crisis. The possible task of developing new sets of antibiotics to replenish the existing ones is daunting to say the least. Searching for adjuvants that rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adadf5703cc696bb0d78aef3323554d7
https://doi.org/10.1021/acsinfecdis.2c00121
https://doi.org/10.1021/acsinfecdis.2c00121
Autor:
Susanna F. Greer, Zehava Eichenbaum, Ya Shu Huang, Nilanjana Chatterjee, Lawrence M. Kauvar, Kristin V. Lyles, Julie E. Morgan
Publikováno v:
J Infect Dis
Background A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake and provides an effective target for active and passive immunization. Here, we isolated human monoclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e991f5169d6d5fda45d44169134393
https://doi.org/10.1093/infdis/jiaa540
https://doi.org/10.1093/infdis/jiaa540
Autor:
Jorge E. Vidal, Yoann Le Breton, Zehava Eichenbaum, Shrikant Pawar, Fahmina Akhter, Edroyal Womack, Kevin S. McIver
Publikováno v:
Infection and Immunity. 89
Streptococcus pneumoniae grows in biofilms during both asymptomatic colonization and infection. Pneumococcal biofilms on abiotic surfaces exhibit delayed growth and lower biomass and lack the structures seen on epithelial cells or during nasopharynge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07aab6c83f7446166fb1ff723d9cbb3a
https://doi.org/10.1128/iai.00779-20
https://doi.org/10.1128/iai.00779-20
Autor:
Tapiwa Chiura, Ian Davis, Zehava Eichenbaum, Aimin Liu, Jiafeng Geng, Piotr J. Mak, Ankita J Sachla, Francis K. Yoshimoto, Jiasong Li, Ephrahime S Traore
Publikováno v:
Molecules, Vol 26, Iss 549, p 549 (2021)
Molecules
Volume 26
Issue 3
Molecules
Volume 26
Issue 3
HupZ is an expected heme degrading enzyme in the heme acquisition and utilization pathway in Group A Streptococcus. The isolated HupZ protein containing a C-terminal V5-His6 tag exhibits a weak heme degradation activity. Here, we revisited and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5782b3a65a6818c2b4a75820c9663546
https://www.mdpi.com/1420-3049/26/3/549
https://www.mdpi.com/1420-3049/26/3/549