Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Zeguang Wu"'
Publikováno v:
BioTechniques, Vol 63, Iss 5, Pp 205-214 (2017)
For immunological research on the human cytomegalovirus (HCMV), a virus that combines the broad cell tropism of clinical isolates, efficient replication in cell culture, the complete set of MHC-I modulator genes, and suitability for genetic engineeri
Externí odkaz:
https://doaj.org/article/01ce051940fe44bb94411db2bf05e563
Autor:
Zeguang Wu, Narmadha Subramanian, Eva-Maria Jacobsen, Kerstin Laib Sampaio, Johannes van der Merwe, Manfred Hönig, Thomas Mertens
Publikováno v:
Microorganisms, Vol 7, Iss 11, p 546 (2019)
The recombination-activating genes (RAGs) and the DNA cross-link repair 1C gene (DCLRE1C) encode the enzymes RAG1, RAG2 and Artemis. They are critical components of the V(D)J recombination machinery. V(D)J recombination is well known as a prerequisit
Externí odkaz:
https://doaj.org/article/8d897f806eb642d287d4e783a28612e1
Autor:
Katharine C. Hsu, Peter M Conaty, Colleen M. Lau, Joseph C. Sun, Thomas Mertens, Ann B. Hill, Kerstin Laib Sampaio, M. Kazim Panjwani, Stuart P. Adler, Nai-Kong V. Cheung, Zeguang Wu, Rosa Sottile, Katja Srpan, Juliet N. Barker, Jean-Benoît Le Luduec
Publikováno v:
The Journal of Immunology. 207:2534-2544
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f2252fe439db89b51627fe509cd82e
https://doi.org/10.4049/jimmunol.2001319
https://doi.org/10.4049/jimmunol.2001319
Autor:
Sam Sheppard, Grégoire Altan-Bonnet, Zeguang Wu, Yi Zhong, Colleen M. Lau, Soo Park, Jayajit Das, Katharine C. Hsu, Joseph C. Sun
Publikováno v:
Sci Signal
Interactions between human leukocyte antigen (HLA) molecules on target cells and the inhibitory killer cell immunoglobulin-like receptors (KIRs) and heterodimeric inhibitory receptor CD94-NKG2A on human natural killer (NK) cells shape and program var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612f85f6e474e276af2e5ec2ad240577
https://europepmc.org/articles/PMC8791782/
https://europepmc.org/articles/PMC8791782/
Autor:
Guanglei Li, Xiangyang Li, Songkuan Zhuang, Liren Wang, Yifan Zhu, Yangcan Chen, Wen Sun, Zeguang Wu, Zhuo Zhou, Jia Chen, Xingxu Huang, Jin Wang, Dali Li, Wei Li, Haoyi Wang, Wensheng Wei
Publikováno v:
Science China. Life sciences. 65(4)
The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats (CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574f3b2b347ae878648cd2ab52e5e5b9
https://pubmed.ncbi.nlm.nih.gov/35235150
https://pubmed.ncbi.nlm.nih.gov/35235150
Autor:
Liang Qu, Zongyi Yi, Yong Shen, Liangru Lin, Feng Chen, Yiyuan Xu, Zeguang Wu, Huixian Tang, Xiaoxue Zhang, Feng Tian, Chunhui Wang, Xia Xiao, Xiaojing Dong, Li Guo, Shuaiyao Lu, Chengyun Yang, Cong Tang, Yun Yang, Wenhai Yu, Junbin Wang, Yanan Zhou, Qing Huang, Ayijiang Yisimayi, Yunlong Cao, Youchun Wang, Zhuo Zhou, Xiaozhong Peng, Jianwei Wang, Xiaoliang Sunney Xie, Wensheng Wei
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its emerging variants of concern (VOC), such as Delta (B.1.617.2) and Omicron (B.1.1.529), has continued to drive the worldwide pandemic. Therefore, there is a high demand for vaccines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1742d9cc75995f4aa279adf8d386b47
https://doi.org/10.1101/2021.03.16.435594
https://doi.org/10.1101/2021.03.16.435594
Autor:
Zeguang, Wu, Colleen M, Lau, Rosa, Sottile, Jean-Benoît, Le Luduec, M Kazim, Panjwani, Peter M, Conaty, Katja, Srpan, Kerstin, Laib Sampaio, Thomas, Mertens, Stuart P, Adler, Ann B, Hill, Juliet N, Barker, Nai-Kong V, Cheung, Joseph C, Sun, Katharine C, Hsu
Publikováno v:
J Immunol
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f677e0da97e5ab48e4dbfb6e04502d7d
https://pubmed.ncbi.nlm.nih.gov/34625521
https://pubmed.ncbi.nlm.nih.gov/34625521
Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs
Autor:
Huazheng Ma, Shiyou Zhu, Ping Xu, Yiyuan Xu, Zhongzheng Cao, Zhiheng Liu, Zeguang Wu, Ying Bao, Ying Liu, Wensheng Wei, Zhuo Zhou
Publikováno v:
Nature biotechnology. 39(11)
Canonical CRISPR-knockout (KO) screens rely on Cas9-induced DNA double-strand breaks (DSBs) to generate targeted gene KOs. These methodologies may yield distorted results because DSB-associated effects are often falsely assumed to be consequences of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912ec5857da075c47690d510a224efb1
https://pubmed.ncbi.nlm.nih.gov/34358458
https://pubmed.ncbi.nlm.nih.gov/34358458
Autor:
Giada Frascaroli, Luka Cicin-Sain, Kerstin Laib Sampaio, Thomas Mertens, Narmadha Subramanian, Frank Reister, Zeguang Wu
Publikováno v:
Journal of General Virology. 98:3068-3085
Apart from classical antigen-presenting cells (APCs) like dendritic cells and macrophages, there are semiprofessional APCs such as endothelial cells (ECs) and Langerhans' cells. Human cytomegalovirus (HCMV) infects a wide range of cell types includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ac688be6f300d9eddefe30dc7c66
https://doi.org/10.1099/jgv.0.000976
https://doi.org/10.1099/jgv.0.000976
Autor:
Hubert Schrezenmeier, Paul Schnitzler, Donald Bunjes, Anthony D. Ho, Peter Dreger, Angela Hückelhoven, Hartmut Döhner, Markus Wiesneth, Marlies Götz, Peter Schauwecker, Lei Wang, Birgit Michels, Susanne Hofmann, Michael Schmitt, Thomas Mertens, Anita Schmitt, Volker Eckstein, Patrick Wuchter, Jochen Greiner, Birgit Maccari, Zeguang Wu, Jürgen Kuball
Publikováno v:
Theranostics
Theranostics, 7(6), 1705. Ivyspring International Publisher
Theranostics, 7(6), 1705. Ivyspring International Publisher
Rationale: Patients receiving an allogeneic stem cell graft from cytomegalovirus (CMV) seronegative donors are particularly prone to CMV reactivation with a high risk of disease and mortality. Therefore we developed and manufactured a novel vaccine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669048c91531213d65c41e92b7239f09
http://europepmc.org/articles/PMC5436522
http://europepmc.org/articles/PMC5436522