Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zegao, Jin"'
Autor:
Xiaoyang Dai, Yang Lu, Zizheng Gao, Wenhu Zhan, Yongzhou Hu, Dan Li, Xiaowu Dong, Sheng Haichao, Binhui Chen, Bo Yang, Qinjie Weng, Zegao Jin, Jinxin Che, Peihua Luo, Qiaojun He, Jian Gao
Publikováno v:
Journal of Medicinal Chemistry. 64:12163-12180
Rash is one of the primary dose-limiting toxicities of Akt (protein kinase B) inhibitors in clinical trials. Here, we demonstrate the inhibition of Akt2 isozyme may be a driver for keratinocyte apoptosis, which promotes us to search for new selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503ce14da4d4662e979089deb0dff82d
https://doi.org/10.1021/acs.jmedchem.1c00815
https://doi.org/10.1021/acs.jmedchem.1c00815
Autor:
Jieqiong You, Hong Zhu, Bo Yang, Zegao Jin, Jinxin Che, Fangjie Yan, Ji Cao, Binhui Chen, Qiaojun He, Jiangfeng Xie, Yongzhou Hu, Xiaowu Dong, Gang Cheng
Publikováno v:
Journal of Medicinal Chemistry. 64:8621-8643
The gain of cell motility is an essential prerequisite for cancer metastasis. The ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1) has been demonstrated to regulate hypoxia-driven tumor cell migration. However, there is still a lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9274212d95ca378d8647168a5d01f76c
https://doi.org/10.1021/acs.jmedchem.1c00586
https://doi.org/10.1021/acs.jmedchem.1c00586
Autor:
Jinxin, Che, Xiaoyang, Dai, Jian, Gao, Haichao, Sheng, Wenhu, Zhan, Yang, Lu, Dan, Li, Zizheng, Gao, Zegao, Jin, Binhui, Chen, Peihua, Luo, Bo, Yang, Yongzhou, Hu, Qiaojun, He, Qinjie, Weng, Xiaowu, Dong
Publikováno v:
Journal of medicinal chemistry. 64(16)
Rash is one of the primary dose-limiting toxicities of Akt (protein kinase B) inhibitors in clinical trials. Here, we demonstrate the inhibition of Akt2 isozyme may be a driver for keratinocyte apoptosis, which promotes us to search for new selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98889dcc77ffd7e58a5fff9463e19276
https://pubmed.ncbi.nlm.nih.gov/34375113
https://pubmed.ncbi.nlm.nih.gov/34375113
Autor:
Zegao Jin, Bo Yang, Qinjie Weng, Yongzhou Hu, Qiaojun He, Yubo Zhou, Gang Cheng, Mengting Zhao, Yanmei Zhao, Wenhu Zhan, Jia Li, Jinxin Che, Xiaoyang Dai, Tian Tian, Yizhe Wu, Yanfei Shao, Lei Xu, Xiaowu Dong
Publikováno v:
Journal of Medicinal Chemistry. 62:7264-7288
A series of 3,4-disubstituted piperidine derivatives were obtained based on a conformational restriction strategy and a lead compound, A12, that exhibited potent in vitro and in vivo antitumor efficacies; however, obvious safety issues limited its fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9911c30b563ae26f56fe26cc8bcedc0
https://doi.org/10.1021/acs.jmedchem.9b00891
https://doi.org/10.1021/acs.jmedchem.9b00891
Publikováno v:
Medicinal Chemistry Research. 24:1369-1379
p53 is a powerful tumor suppressor, and p53–MDM2 protein–protein interaction has been considered as an attractive cancer therapeutic target. More recently developed small molecules exert their effects by interrupting the p53–MDM2 binding and en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89407e979bdb2e387f098c29a4b47a73
https://doi.org/10.1007/s00044-014-1089-7
https://doi.org/10.1007/s00044-014-1089-7