Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zeev Slobodnik"'
Autor:
Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber
Publikováno v:
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Externí odkaz:
https://doaj.org/article/8ec54c204be64101928f8e9ebb75bef6
Autor:
Daniel Stein, Zeev Slobodnik, Benjamin Tam, Monica Einav, Barak Akabayov, Shimon Berstein, Debra Toiber
Publikováno v:
Aging Cell. 21
Loss of proteostasis can occur due to mutations, the formation of aggregates, or general deficiency in the correct translation and folding of proteins. These phenomena are commonly observed in pathologies, but most significantly, loss of proteostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935a564f066c206b561722db6f8e4012
https://doi.org/10.1111/acel.13738
https://doi.org/10.1111/acel.13738
Autor:
Alfredo Garcia Venzor, Debra Toiber, Ekaterina Khrameeva, Anastasia Golova, Daniel Stein, Monica Einav, Shai Kaluski, Amir Mizrahi, Adam Saretzky, Zeev Slobodnik
Publikováno v:
Aging
Aging (Albany NY)
Aging (Albany NY)
Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfa85d6caee51750ed596ffd0836d18
https://doi.org/10.18632/aging.202755
https://doi.org/10.18632/aging.202755
Autor:
Segev Naveh Tassa, Shiran Lacham-Hartman, Debra Toiber, Zeev Slobodnik, Niv Papo, Shani Ben Zichri, Ofek Oren, Raz Jelinek, Ekaterina Eremenko
Publikováno v:
ACS chemical neuroscience. 12(9)
It is currently believed that molecular agents that specifically bind to and neutralize the toxic proteins/peptides, amyloid β (Aβ42), tau, and the tau-derived peptide PHF6, hold the key to attenuating the progression of Alzheimer's disease (AD). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c2f0d7c6a4b6b957340b4637ca7bec
https://pubmed.ncbi.nlm.nih.gov/33904703
https://pubmed.ncbi.nlm.nih.gov/33904703
Publikováno v:
Cell Reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::a6e98416951a130516beefb33b9fedc1
Autor:
Ekaterina Eremenko, Lior Onn, Shai Kaluski, Thomas Arendt, Debra Toiber, Martina K. Brückner, Monica Einav, Uwe Ueberham, Miguel Portillo, Daniel Stein, Zeev Slobodnik
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegenerative patients. Here, we show that Tau hyper-acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee3d9894f875469e06ca354859dabb1
https://doi.org/10.1101/2020.09.01.276782
https://doi.org/10.1101/2020.09.01.276782
Autor:
Zeev Slobodnik, Daniel Stein, Miguel Portillo, Gal Cleitman, Ido Shirat, Fabian Erdel, Barak Akabayov, Stefan Ilic, Lior Onn, Debra Toiber, Shai Kaluski, Monica Einav
Publikováno v:
eLife
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51636⟩
'eLife ', vol: 9, pages: e51636-1-e51636-26 (2020)
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51636⟩
'eLife ', vol: 9, pages: e51636-1-e51636-26 (2020)
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dd07dbc54e6329ea5e163ca2a7a2c0
https://doi.org/10.7554/elife.51636
https://doi.org/10.7554/elife.51636
Autor:
Zeev Slobodnik, Debra Toiber, Daniel Stein, Lior Onn, Gal Cleitman, Monica Einav, Miguel Portillo, Barak Akabayov, Fabian Erdel, Stefan Ilic, Shai Kaluski, Ido Shirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0fc6ba377eed6bc1ac4e7de6254a0e2
https://doi.org/10.7554/elife.51636.sa2
https://doi.org/10.7554/elife.51636.sa2
Autor:
Daniel Stein, Alfredo Garcia-Venzor, Monica Einav, Zeev Slobodnik, Debra Toiber, Uwe Ueberham, Shai Kaluski, Adam Zaretsky, Miguel Portillo, Martina K. Brückner, Ekaterina Eremenko, Lior Onn, Thomas Arendt
Publikováno v:
Cell Reports. 35:109035
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegeneration. Here, we show that Tau hyper-acetylation at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734f1f62c0c98ed888b1fb8339b727ec
https://doi.org/10.1016/j.celrep.2021.109035
https://doi.org/10.1016/j.celrep.2021.109035