Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Zeev Pancer"'
Autor:
Zeev, Pancer, Chris T, Amemiya, Götz R A, Ehrhardt, Jill, Ceitlin, G Larry, Gartland, Max D, Cooper
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(5)
Publikováno v:
The Journal of Immunology. 192:3207-3217
Although the negative selection of self-reactive B cells in the bone marrow of mammals has been clearly demonstrated, it remains unclear in models of gut-associated B cell lymphopoiesis, such as that of the chicken (Gallus gallus). We have generated
Autor:
William E. Bentley, Xiaohua Yang, Xiaowen Shi, Eunkyoung Kim, Gary W. Rubloff, Gregory F. Payne, Yi Liu, Zeev Pancer, Reza Ghodssi
Publikováno v:
Advanced Functional Materials. 20:1645-1652
Autor:
S. Annie Gai, Roy A. Mariuzza, K. Dane Wittrup, Zeev Pancer, Gang Xu, C. Alejandro Velikovsky, Satoshi Tasumi, Martin F. Flajnik
Publikováno v:
Proceedings of the National Academy of Sciences. 106:12891-12896
Lamprey are members of the ancestral vertebrate taxon (jawless fish), which evolved rearranging antigen receptors convergently with the jawed vertebrates. But instead of Ig superfamily domains, lamprey variable lymphocyte receptors (VLRs) consist of
Autor:
Zeev Pancer, Victoria G. Liston, Lizhi Liang, Lakshminarayan M. Iyer, Igor B. Rogozin, L. Aravind, Youri I. Pavlov, Galina V. Glazko
Publikováno v:
Nature Immunology. 8:647-656
The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey geno
Autor:
Zeev Pancer, Max D. Cooper
Publikováno v:
Annual Review of Immunology. 24:497-518
Approximately 500 mya two types of recombinatorial adaptive immune systems appeared in vertebrates. Jawed vertebrates generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragmen
Autor:
Jun Kasamatsu, Chris T. Amemiya, Masanori Kasahara, Max D. Cooper, Nil Ratan Saha, Takashi Suzuki, Zeev Pancer
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9224-9229
A previously uncharacterized type of variable lymphocyte receptors (VLR) was identified recently in the Sea lamprey. This jawless vertebrate generates an extensive VLR repertoire through differential insertion of neighboring diverse leucine-rich repe
Autor:
John P. Cannon, Diana Skapura, Max D. Cooper, Zeev Pancer, M. Gail Mueller, Robert N. Haire, Gary W. Litman
Publikováno v:
Immunogenetics. 56:924-929
Immunoglobulins (Igs) and T cell antigen receptors (TCRs) that undergo somatic diversification have not been identified in the two extant orders of jawless vertebrates, which occupy essential positions in terms of understanding the evolution of the e
Publikováno v:
Proceedings of the National Academy of Sciences. 101:13273-13278
All jawed vertebrates have highly diverse lymphocyte receptors, which allow discrimination between self and nonself antigens as well as the recognition of potential pathogens. Key elements of the anticipatory recombinatorial immune system in jawed ve
Autor:
Max D. Cooper, G. Larry Gartland, Götz R. A. Ehrhardt, Chris T. Amemiya, Jill Ceitlin, Zeev Pancer
Publikováno v:
Nature. 430:174-180
Although jawless vertebrates are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates. Our search for the phylogenetic roots of adaptive immunity in