Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and CancerSummary

Autor: Nicola Currey, Zeenat Jahan, C. Elizabeth Caldon, Phuong N. Tran, Fahad Benthani, Penelope De Lacavalerie, Daniel L. Roden, Brian S. Gloss, Claudia Campos, Elaine G. Bean, Amanda Bullman, Saskia Reibe-Pal, Marcel E. Dinger, Mark A. Febbraio, Stephen J. Clarke, Jane E. Dahlstrom, Maija R.J. Kohonen-Corish

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 819-839 (2019)

Background & Aims: The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous l

Externí odkaz: https://doaj.org/article/3f5a2d0c39a64c9b94fae8baddfca8d1

Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth

Autor: John E. Pimanda, Bryan W. Day, Kerrie L. McDonald, Ashwin Unnikrishnan, Han Shen, Govardhan Anande, Shruthi Subramanian, Zeenat Jahan, Toni Rose Jue, Kathleen S. Ensbey, Sylvia A. Chung, Brett W. Stringer, Julie A.I. Thoms, Anchit Khanna

Figure S1, related to Figure 1: Expression and correlation of CHK1 and CIP2A in multiple glioma cohorts. Figure S2, related to Figure 1: Overall survival and mRNA expression of PP2A subunits in glioma patients. Figure S3, related to Figure 1: Role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797ba9f3cc2355aafc11bcb0f6c2b6c1
https://doi.org/10.1158/1541-7786.22515163.v1

Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

Autor: Mark A. Jenkins, Maija R.J. Kohonen-Corish, Nicola Currey, Sabine Meessen, Zeenat Jahan, Hannah W. Parker, Daniel D. Buchanan, Eva Segelov, John L. Hopper, Jane E. Dahlstrom

Publikováno v: Cancers
Volume 13
Issue 14
Cancers, Vol 13, Iss 3529, p 3529 (2021)

Simple Summary A type of DNA mismatch repair defect known as “elevated microsatellite alterations at selected tetranucleotide repeats” (EMAST) is found across many different cancers. Tetranucleotide microsatellite instability, which is caused by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5d06c4f2c61d1dbb1cee8c4893e58d
https://hdl.handle.net/10453/154593

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation

Autor: Robert Brink, Christopher J. Jolly, Igor Stevanovski, Wolfgang Weninger, Caitlin Shepard, Zeenat Jahan, Daniel Bosnjak, Baek Kim, Timothy Durack, Eddy Sanchai Thientosapol, Michelle van Geldermalsen, Jeff Holst

Publikováno v: Proceedings of the National Academy of Sciences. 115:4921-4926

Significance Antibody affinity rises during immune responses to viruses via antibody gene somatic hypermutation and Darwinian selection of mutated B cells—in a time frame of days. The enzyme activation-induced deaminase (AID) initiates hypermutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d925a945bd7ac34b28ae60dbdc1dc4b
https://doi.org/10.1073/pnas.1719771115

Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

Autor: Saskia Reibe-Pal, Mark A. Febbraio, Amanda Bullman, Brian S. Gloss, Elaine G. Bean, C. Elizabeth Caldon, Stephen Clarke, Marcel E. Dinger, Nicola Currey, Daniel L. Roden, Maija R.J. Kohonen-Corish, Phuong N. Tran, Penelope De Lacavalerie, Fahad Benthani, Jane E. Dahlstrom, Claudia Guimarães Camargo Campos, Zeenat Jahan

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 819-839 (2019)

Background & Aims The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c468af758b15860c11906bdd37df6fef