Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zeenat A. Shyr"'
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identi
Externí odkaz:
https://doaj.org/article/5e46c34574a140cd9c8b3546671f327d
Autor:
Christopher H. Emfinger, Réka Lőrincz, Yixi Wang, Nathaniel W. York, Soma S. Singareddy, Jennifer M. Ikle, Robert C. Tryon, Conor McClenaghan, Zeenat A. Shyr, Yan Huang, Christopher A. Reissaus, Dirk Meyer, David W. Piston, Krzysztof Hyrc, Maria S. Remedi, Colin G. Nichols
Publikováno v:
Physiological Reports, Vol 7, Iss 11, Pp n/a-n/a (2019)
Abstract Islet β‐cell membrane excitability is a well‐established regulator of mammalian insulin secretion, and defects in β‐cell excitability are linked to multiple forms of diabetes. Evolutionary conservation of islet excitability in lower
Externí odkaz:
https://doaj.org/article/a0d6372c22d44973a78da986fad96465
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to be a global threat since its emergence. Although several COVID-19 vaccines have become available, the prospective timeframe for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e825855d5b285f91c46e3c4a07b74af7
http://europepmc.org/articles/PMC8686716
http://europepmc.org/articles/PMC8686716
Publikováno v:
Diabetes. 71
Diabetes progression is characterized by loss of functional β-cell mass. Non-obese KATP-GOF mouse models of human neonatal diabetes developed severe diabetes due to lack of insulin secretion; with a marked loss of β-cell mass/identity and dediffere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b8884e36aca0537c8e2702061a60d3f
https://doi.org/10.2337/db22-318-or
https://doi.org/10.2337/db22-318-or
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics
Coronavirus disease 2019 (COVID-19) is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus that was first detected in December of 2019 in Wuhan, China, and has rapidly spread worldwide. The search for a suit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8187bb515506a72b3e0c45325495761
https://doi.org/10.1124/jpet.120.000123
https://doi.org/10.1124/jpet.120.000123
Autor:
Zihan Yan, Manuela Fortunato, Zeenat A. Shyr, Amy L. Clark, Matt Fuess, Colin G. Nichols, Maria S. Remedi
Publikováno v:
Diabetes. 71(6)
β-Cell failure and loss of β-cell mass are key events in diabetes progression. Although insulin hypersecretion in early stages has been implicated in β-cell exhaustion/failure, loss of β-cell mass still occurs in KATP gain-of-function (GOF) mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2352594758119e7743de2186c5f8a0ec
https://pubmed.ncbi.nlm.nih.gov/35294000
https://pubmed.ncbi.nlm.nih.gov/35294000
Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e01b341c7df357a90326ff8e088745d
https://doi.org/10.1101/2021.09.17.460837
https://doi.org/10.1101/2021.09.17.460837
Publikováno v:
PloS one. 17(2)
Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfde0b052922d90807d5280770c0b05
https://pubmed.ncbi.nlm.nih.gov/35180212
https://pubmed.ncbi.nlm.nih.gov/35180212
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Persistent hyperglycemia is causally associated with pancreatic β-cell dysfunction and loss of pancreatic insulin. Glucose normally enhances β-cell excitability through inhibition of KATP channels, opening of voltage-dependent calcium channels, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ee045e6f816c2ed976f0c645fe94ad
http://link.springer.com/article/10.1038/s41598-019-43452-8
http://link.springer.com/article/10.1038/s41598-019-43452-8