Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Zeda Zhang"'
Autor:
Ninghui Mao, Zeda Zhang, Young Sun Lee, Danielle Choi, Aura Agudelo Rivera, Dan Li, Cindy Lee, Samuel Haywood, Xiaoping Chen, Qing Chang, Guotai Xu, Hsuan-An Chen, Elisa de Stanchina, Charles Sawyers, Neal Rosen, Andrew C. Hsieh, Yu Chen, Brett S. Carver
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Understanding the mechanisms driving PI3K isoform dependency in prostate cancer can help the design of future clinical trials. Here, the authors show that gain-of-function mutations in PIK3CA or PIK3CB can confer PI3K p110 isoform dependency and that
Externí odkaz:
https://doaj.org/article/907e2e85e15748fa85c06a824495c169
Autor:
Bryan C. Szeglin, Chao Wu, Michael R. Marco, Hyun Sung Park, Zeda Zhang, Bing Zhang, Julio Garcia‐Aguilar, R. Daniel Beauchamp, X. Steven Chen, J. Joshua Smith
Publikováno v:
Cancer Reports, Vol 5, Iss 1, Pp n/a-n/a (2022)
Abstract Background Colorectal cancer is the second‐leading cause of cancer‐related mortality in the United States and a leading cause of cancer‐related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the
Externí odkaz:
https://doaj.org/article/f76dec1243af45d18f90e3544bb643b1
Autor:
Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161084 (2016)
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases. The fusion event is an early, if not initiating, event in prostate cancer,
Externí odkaz:
https://doaj.org/article/c7848b1536d844d4976f31c6711bd4ab
Autor:
Brett S. Carver, Yu Chen, Anuradha Gopalan, Charles L. Sawyers, Neal Rosen, Danielle Choi, Zeda Zhang, Patrick Sullivan, Young Sun Lee, Shangqian Wang, Haley Hieronymus, Sunyana Gadal, Wenhuo Hu, Dong Gao, Ninghui Mao
Genomic rearrangements leading to the aberrant expression of ERG are the most common early events in prostate cancer and are significantly enriched for the concomitant loss of PTEN. Genetically engineered mouse models reveal that ERG overexpression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabd2d2fb63da659913b574b2aa663f2
https://doi.org/10.1158/0008-5472.c.6512302.v1
https://doi.org/10.1158/0008-5472.c.6512302.v1
Autor:
Brett S. Carver, Yu Chen, Anuradha Gopalan, Charles L. Sawyers, Neal Rosen, Danielle Choi, Zeda Zhang, Patrick Sullivan, Young Sun Lee, Shangqian Wang, Haley Hieronymus, Sunyana Gadal, Wenhuo Hu, Dong Gao, Ninghui Mao
List of most significantly differentially expressed genes following ERG knock-out.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70da04c32528f3aca2f277f9c7b94c1b
https://doi.org/10.1158/0008-5472.22426318.v1
https://doi.org/10.1158/0008-5472.22426318.v1
Autor:
Xue-Feng Li, Cigdem Selli, Han-Lin Zhou, Jian Cao, Shuiqing Wu, Ruo-Yu Ma, Ye Lu, Cheng-Bin Zhang, Bijie Xun, Alyson D. Lam, Xiao-Cong Pang, Anu Fernando, Zeda Zhang, Asier Unciti-Broceta, Neil O. Carragher, Prakash Ramachandran, Neil C. Henderson, Ling-Ling Sun, Hai-Yan Hu, Gui-Bo Li, Charles Sawyers, Bin-Zhi Qian
Publikováno v:
Li, X, Selli, C, Zhou, H, Cao, J, Wu, S, Ma, R, Lu, Y, Zhang, C, Xun, B, Lam, A D, Pang, X, Fernando, A, Zhang, Z, Unciti-Broceta, A, Carragher, N O, Ramachandran, P, Henderson, N C, Sun, L, Hu, H, Li, G, Sawyers, C & Qian, B 2023, ' Macrophages promote anti-androgen resistance in prostate cancer bone disease ', Journal of Experimental Medicine, vol. 220, no. 4 . https://doi.org/10.1084/jem.20221007
Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of disease mechanisms, the specific contribution of the metastatic mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26da5f113bef6a77bec6c7bdb241903
https://www.pure.ed.ac.uk/ws/files/328311624/Macrophage_promotion_of_anti_androgen_resistance_in_metastatic_hormone_sensitive_prostate_cancer.pdf
https://www.pure.ed.ac.uk/ws/files/328311624/Macrophage_promotion_of_anti_androgen_resistance_in_metastatic_hormone_sensitive_prostate_cancer.pdf
Autor:
Hsuan-An Chen, Samuel Haywood, Ninghui Mao, Neal Rosen, Zeda Zhang, Brett S. Carver, Charles L. Sawyers, Dan Li, Qing Chang, Andrew C. Hsieh, Elisa de Stanchina, Xiaoping Chen, Danielle Choi, Yu Chen, Young Sun Lee, Cindy Lee, Aura Agudelo Rivera, Guotai Xu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Previous studies have suggested that PTEN loss is associated with p110β signaling dependency, leading to the clinical development of p110β-selective inhibitors. Here we use a panel pre-clinical models to reveal that PI3K isoform dependency is not g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed600065b6e9a2c5d108bd0f87fa1a6
https://doaj.org/article/907e2e85e15748fa85c06a824495c169
https://doaj.org/article/907e2e85e15748fa85c06a824495c169
Autor:
Charles L. Sawyers, Danielle Choi, Sunyana Gadal, Dong Gao, Wenhuo Hu, Yu Chen, Young Sun Lee, Neal Rosen, Anuradha Gopalan, Zeda Zhang, Brett S. Carver, Patrick F. Sullivan, Ninghui Mao, Haley Hieronymus, Shangqian Wang
Publikováno v:
Cancer Res
Genomic rearrangements leading to the aberrant expression of ERG are the most common early events in prostate cancer and are significantly enriched for the concomitant loss of PTEN. Genetically engineered mouse models reveal that ERG overexpression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f8c0705706d9e7320f341c71b81c32
https://doi.org/10.1158/0008-5472.can-19-1394
https://doi.org/10.1158/0008-5472.can-19-1394
Autor:
X Steven Chen, Michael R. Marco, Julio Garcia-Aguilar, J. Joshua Smith, R. Daniel Beauchamp, Bing Zhang, Bryan C. Szeglin, Hyun Sung Park, Zeda Zhang, Chao Wu
Publikováno v:
Cancer Reports, Vol 5, Iss 1, Pp n/a-n/a (2022)
Cancer Reports
Cancer Reports
Background Colorectal cancer is the second‐leading cause of cancer‐related mortality in the United States and a leading cause of cancer‐related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the transfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82970e25bf78332c62bf7eb605ce1da
Autor:
Anuradha Gopalan, Zeda Zhang, Charles L. Sawyers, Katia Manova-Todorova, Huiyong Zhao, Brett S. Carver, Dana E. Rathkopf, Jose Mauricio Mota, Steven P. Balk, Eugine Lee, Young Sun Lee, Chao Wu, Ping Mu, Wouter R. Karthaus, John Wongvipat, Ninghui Mao, Elisa de Stanchina, Menghan Liu, Vianne R. Gao, Xuejun Jiang, Xiaoping Chen, Wassim Abida, Danielle Choi, Mary-Ellen Taplin, Spencer D. Barnes, Philip A. Watson, Joshua W. Russo, Eliot Linton, Hsuan An Chen
Publikováno v:
Cancer cell. 38(2)
Summary Despite the development of second-generation antiandrogens, acquired resistance to hormone therapy remains a major challenge in treating advanced prostate cancer. We find that cancer-associated fibroblasts (CAFs) can promote antiandrogen resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae367b4294f0e9db4f1686dce124a55b
https://pubmed.ncbi.nlm.nih.gov/32782364
https://pubmed.ncbi.nlm.nih.gov/32782364