Zobrazeno 1 - 10
of 2 037
pro vyhledávání: '"Zebrafish larvae"'
Publikováno v:
MethodsX, Vol 12, Iss , Pp 102492- (2024)
Zebrafish larvae are a model organism increasingly used in the study of the effect of neuroactive chemicals on vertebrate sleep/wake cycles. Sleep disturbances have a negative impact on mood, cognition and overall health. Here we present a protocol t
Externí odkaz:
https://doaj.org/article/98ffa66434c947aaa04c4c9b9901f62b
Autor:
Laxmi Sen Thakuri, Chul Min Park, Jin Yeong Choi, Hyeon-A Kim, Han Kyu Lim, Jin Woo Park, Dong Wook Kim, Dong Young Rhyu
Publikováno v:
Fisheries and Aquatic Sciences, Vol 27, Iss 2, Pp 122-135 (2024)
Obesity is a disease involving mechanisms of fat accumulation, low-grade inflammatory cytokine release, and mitochondrial dysfunction. The aim of the current study was to investigate the effects of abalone intestine extract on fat metabolism in 3T3-L
Externí odkaz:
https://doaj.org/article/f5fc062b661642708eade0bba6c910e2
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 14, Iss 1, Pp 82-90 (2024)
Background and aim: Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to insulin. Loss of insulin sensitivity disrupts glucose homeostasis and elevates the risk of developing the metabolic syndrome that inclu
Externí odkaz:
https://doaj.org/article/51855b3e6ba94e149757505e09a657a0
Autor:
Clovis P. Wouters, Benjamin Klein, Nicholas Price, François Boemer, Marianne L. Voz, Dominique-Marie Votion
Publikováno v:
Molecules, Vol 29, Iss 20, p 4954 (2024)
Hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG) are protoxins produced by Sapindaceae plants, particularly Acer pseudoplatanus, and are responsible for causing atypical myopathy (AM) in equids. These protoxins metabolise into toxic compoun
Externí odkaz:
https://doaj.org/article/22ffd636e8df42978d7985daa28d7d1a
Autor:
Hee Jin Jung, Hyeon Seo Park, Hye Jin Kim, Hye Soo Park, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1248 (2024)
2-Mercaptomethylbenzo[d]imidazole (2-MMBI) derivatives were designed and synthesized as tyrosinase (TYR) chelators using 2-mercaptomethylimidazole scaffolds. Seven of the ten 2-MMBI derivatives exhibited stronger inhibition of mushroom TYR activity t
Externí odkaz:
https://doaj.org/article/09e7f6b7bc374893b73f581c8cd94b62
Autor:
Marta Marszalek-Grabska, Monika Turska-Kozlowska, Edyta Kaczorek-Lukowska, Katarzyna Wicha-Komsta, Waldemar A. Turski, Andrzej K. Siwicki, Kinga Gawel
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1148 (2024)
Kynurenic acid (KYNA) is a metabolite of tryptophan formed on the kynurenine pathway. Its pharmacological effects are relatively well characterized in mammals, whereas its role in fish is poorly understood. Therefore, the aim of the study was to expa
Externí odkaz:
https://doaj.org/article/44ee75576d6342c2b2d40231e907ca10
Autor:
Hee Jin Jung, Hyeon Seo Park, Hye Soo Park, Hye Jin Kim, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 29, Iss 17, p 4162 (2024)
Inspired by the potent tyrosinase inhibitory activity of phenolic compounds with a 2-phenylbenzo[d]thiazole scaffold, we explored phenolic compounds 1–15 with 2-phenylbenzo[d]oxazole, which is isosterically related to 2-phenylbenzo[d]thiazole, as n
Externí odkaz:
https://doaj.org/article/95b92502467c43a78d94d637211f1045
Publikováno v:
Toxics, Vol 12, Iss 7, p 527 (2024)
Microcystin-LR (MCLR) poses a significant threat to aquatic ecosystems and public health. This study investigated the protective effects of the probiotic Lactobacillus rhamnosus against MCLR-induced developmental toxicity in zebrafish larvae. Zebrafi
Externí odkaz:
https://doaj.org/article/e59cc9cf31364c1fa225847e6eccc10e
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e26167- (2024)
Jiuzao, the residue from Baijiu production, has shown radical scavenging properties in prior investigations, suggesting its potential as a hepatoprotective agent against acute liver damage. This study reveals that Jiuzao polysaccharides ameliorated l
Externí odkaz:
https://doaj.org/article/3b2c15096ffb45aa9849d8619913758f
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116096- (2024)
Drug repurposing can accelerate drug development while reducing the cost and risk of toxicity typically associated with de novo drug design. Several disorders lacking pharmacological solutions and exhibiting poor results in clinical trials - such as
Externí odkaz:
https://doaj.org/article/f42096f654b043fab1198133efb03db0