Conserved and divergent arms of the antiviral response in the duplicated genomes of salmonid fishes

Autor: Clark, Thomas C, Naseer, Shahmir, Gundappa, Manu Kumar, Laurent, Audrey, Perquis, Aline, Collet, Bertrand, Macqueen, Daniel J, Martin, Samuel A M, Boudinot, Pierre

Publikováno v: Clark, T C, Naseer, S, Gundappa, M K, Laurent, A, Perquis, A, Collet, B, Macqueen, D J, Martin, S A M & Boudinot, P 2023, ' Conserved and divergent arms of the antiviral response in the duplicated genomes of salmonid fishes ', Genomics, vol. 115, no. 4, 110663, pp. 1-13 . https://doi.org/10.1016/j.ygeno.2023.110663

Antiviral innate immunity is orchestrated by the interferon system, which appeared in ancestors of jawed vertebrates. Interferon upregulation induces hundreds of interferon-stimulated-genes (ISGs) with effector or regulatory functions. Here we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::7324b2cbe6bdac75aadd10092cc80c6d
https://hdl.handle.net/20.500.11820/27ca9fee-0e94-4b83-8ee0-ac3d762d2f0b

Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

Autor: Medina-Gomez, Carolina, Mullin, Benjamin H, Chesi, Alessandra, Prijatelj, Vid, Kemp, John P, Shochat-Carvalho, Chen, Trajanoska, Katerina, Wang, Carol, Joro, Raimo, Evans, Tavia E, Schraut, Katharina E, Li-Gao, Ruifang, Ahluwalia, Tarunveer S, Zillikens, M Carola, Zhu, Kun, Mook-Kanamori, Dennis O, Evans, Daniel S, Nethander, Maria, Knol, Maria J, Thorleifsson, Gudmar, Prokic, Ivana, Zemel, Babette, Broer, Linda, McGuigan, Fiona E, van Schoor, Natasja M, Reppe, Sjur, Pawlak, Mikolaj A, Ralston, Stuart H, van der Velde, Nathalie, Lorentzon, Mattias, Stefansson, Kari, Adams, Hieab H H, Wilson, Scott G, Ikram, M Arfan, Walsh, John P, Lakka, Timo A, Gautvik, Kaare M, Wilson, James F, Orwoll, Eric S, van Duijn, Cornelia M, Bønnelykke, Klaus, Uitterlinden, Andre G, Styrkársdóttir, Unnur, Akesson, Kristina E, Spector, Timothy D, Tobias, Jonathan H, Ohlsson, Claes, Felix, Janine F, Bisgaard, Hans, Grant, Struan F A, Richards, J Brent, Evans, David M, van der Eerden, Bram, van de Peppel, Jeroen, Ackert-Bicknell, Cheryl, Karasik, David, Kague, Erika, Rivadeneira, Fernando

Publikováno v: Medina-Gomez, C, Mullin, B H, Chesi, A, Prijatelj, V, Kemp, J P, Shochat-Carvalho, C, Trajanoska, K, Wang, C, Joro, R, Evans, T E, Schraut, K E, Li-Gao, R, Ahluwalia, T S, Zillikens, M C, Zhu, K, Mook-Kanamori, D O, Evans, D S, Nethander, M, Knol, M J, Thorleifsson, G, Prokic, I, Zemel, B, Broer, L, McGuigan, F E, van Schoor, N M, Reppe, S, Pawlak, M A, Ralston, S H, van der Velde, N, Lorentzon, M, Stefansson, K, Adams, H H H, Wilson, S G, Ikram, M A, Walsh, J P, Lakka, T A, Gautvik, K M, Wilson, J F, Orwoll, E S, van Duijn, C M, Bønnelykke, K, Uitterlinden, A G, Styrkársdóttir, U, Akesson, K E, Spector, T D, Tobias, J H, Ohlsson, C, Felix, J F, Bisgaard, H, Grant, S F A, Richards, J B, Evans, D M, van der Eerden, B, van de Peppel, J, Ackert-Bicknell, C, Karasik, D, Kague, E & Rivadeneira, F 2023, ' Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis ', Communications Biology, vol. 6, no. 1, 691 . https://doi.org/10.1038/s42003-023-04869-0
Medina-Gomez, C, Mullin, B H, Chesi, A, Prijatelj, V, Kemp, J P, Shochat-Carvalho, C, Trajanoska, K, Wang, C, Joro, R, Evans, T E, Schraut, K E, Li-Gao, R, Ahluwalia, T S, Zillikens, M C, Zhu, K, Mook-Kanamori, D O, Evans, D S, Nethander, M, Knol, M J, Thorleifsson, G, Prokic, I, Zemel, B, Broer, L, McGuigan, F E, van Schoor, N M, Reppe, S, Pawlak, M A, Ralston, S H, van der Velde, N, Lorentzon, M, Stefansson, K, Adams, H H H, Wilson, S G, Ikram, M A, Walsh, J P, Lakka, T A, Gautvik, K M, Wilson, J F, Orwoll, E S, van Duijn, C M, Bønnelykke, K, Uitterlinden, A G, Styrkársdóttir, U, Akesson, K E, Spector, T D, Tobias, J H, Ohlsson, C, Felix, J F, Bisgaard, H, Grant, S F A, Richards, J B, Evans, D M, van der Eerden, B, van de Peppel, J, Ackert-Bicknell, C, Karasik, D, Kague, E & Rivadeneira, F 2023, ' Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis ', Communications biology, vol. 6, no. 1, pp. 691 . https://doi.org/10.1038/s42003-023-04869-0

Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analysis (n ~

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https://curis.ku.dk/portal/da/publications/bone-mineral-density-loci-specific-to-the-skull-portray-potential-pleiotropic-effects-on-craniosynostosis(88c44e23-5a91-4fc4-9d6f-4630753c248f).html

Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium

Autor: Mytlis, Avishag, Kumar, Vineet, Qiu, Tao, Deis, Rachael, Hart, Neta, Levy, Karine, Masek, Markus, Shawahny, Amal, Ahmad, Adam, Eitan, Hagai, Nather, Farouq, Adar-Levor, Shai, Birnbaum, Ramon Y, Elia, Natalie, Bachmann-Gagescu, Ruxandra, Roy, Sudipto, Elkouby, Yaniv M

Publikováno v: Science. 376

A hallmark of meiosis is chromosomal pairing, which requires telomere tethering and rotation on the nuclear envelope through microtubules, driving chromosome homology searches. Telomere pulling toward the centrosome forms the “zygotene chromosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2521973df16400199ebc82ac2e7a00
https://doi.org/10.1126/science.abh3104

OMAMO: orthology-based alternative model organism selection

Autor: Christophe Dessimoz, Adrian Altenhoff, Sina Majidian, Alina Nicheperovich

Publikováno v: Bioinformatics, vol. 38, no. 10, pp. 2965-2966
Bioinformatics, 38 (10)

The conservation of pathways and genes across species has allowed scientists to use non-human model organisms to gain a deeper understanding of human biology. However, the use of traditional model systems such as mice, rats and zebrafish is costly, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ea14b8015a9a73a61a798dd54cdeaf
https://serval.unil.ch/notice/serval:BIB_E49811D00537

Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome

Autor: Tessadori, Federico, Duran, Karen, Knapp, Karen, Fellner, Matthias, Deciphering Developmental Disorders Study, Smithson, Sarah, Beleza Meireles, Ana, Elting, Mariet W, Waisfisz, Quinten, O'Donnell-Luria, Anne, Nowak, Catherine, Douglas, Jessica, Ronan, Anne, Brunet, Theresa, Kotzaeridou, Urania, Svihovec, Shayna, Saenz, Margarita S, Thiffault, Isabelle, Del Viso, Florencia, Devine, Patrick, Rego, Shannon, Tenney, Jessica, van Haeringen, Arie, Ruivenkamp, Claudia A L, Koene, Saskia, Robertson, Stephen P, Deshpande, Charulata, Pfundt, Rolph, Verbeek, Nienke, van de Kamp, Jiddeke M, Weiss, Janneke M M, Ruiz, Anna, Gabau, Elisabeth, Banne, Ehud, Pepler, Alexander, Bottani, Armand, Laurent, Sacha, Guipponi, Michel, Bijlsma, Emilia, Bruel, Ange-Line, Sorlin, Arthur, Willis, Mary, Powis, Zoe, Smol, Thomas, Vincent-Delorme, Catherine, Baralle, Diana, Colin, Estelle, Revencu, Nicole, Calpena, Eduardo, Wilkie, Andrew O M, Chopra, Maya, Cormier-Daire, Valerie, Keren, Boris, Afenjar, Alexandra, Niceta, Marcello, Terracciano, Alessandra, Specchio, Nicola, Tartaglia, Marco, Rio, Marlene, Barcia, Giulia, Rondeau, Sophie, Colson, Cindy, Bakkers, Jeroen, Mace, Peter D, Bicknell, Louise S, van Haaften, Gijs

Publikováno v: American journal of human genetics, Vol. 109, no.4, p. 750-758 (2022)
American journal of human genetics, 109(4), 750-758. Cell Press
American Journal of Human Genetics, 109, 750-758
American Journal of Human Genetics, 109(4), 750-758. CELL PRESS
Deciphering Developmental Disorders Study 2022, ' Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome ', American journal of human genetics, vol. 109, no. 4, pp. 750-758 . https://doi.org/10.1016/j.ajhg.2022.02.003
American Journal of Human Genetics, 109(4), 750-758. Cell Press
American Journal of Human Genetics, 109, 4, pp. 750-758

Contains fulltext : 252023.pdf (Publisher’s version ) (Open Access) Chromatin is essentially an array of nucleosomes, each of which consists of the DNA double-stranded fiber wrapped around a histone octamer. This organization supports cellular proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26baf96963f72d8c775857dfc818214
https://doi.org/10.1016/j.ajhg.2022.02.003