Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

Autor: Fabian Kruse, Federico Tessadori, Erika Tsingos, Vincent M. Christoffels, Malou van den Boogaard, Susanne C. van den Brink, Roeland M. H. Merks, Enrico Sandro Colizzi, Jeroen Bakkers

Publikováno v: eLife, 10:e61733. eLife Sciences Publications
eLife, 10. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 10 (2021)
eLife, 10. eLife Sciences Publications

Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established during embryogenesis. The heart is the first organ to display visible left-right asymmetries through its left-sided positioning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82adc38e0ecfc09fd869d8e4f224b3f
https://pure.amc.nl/en/publications/twisting-of-the-zebrafish-heart-tube-during-cardiac-looping-is-a-tbx5dependent-and-tissueintrinsic-process(617f79c9-e09e-46e7-8fad-7d2194562306).html

Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts

Autor: Emma M. Jenkinson, Andrew P. Badrock, Denis L. J. Lafontaine, Gillian I. Rice, Raymond T. O'Keefe, Siobhan Crilly, Paul R. Kasher, Ludivine Wacheul, Carolina Uggenti, Yanick J. Crow

Publikováno v: Am J Hum Genet
Badrock, A, Uggenti, C, Wacheul, L, Crilly, S, Jenkinson, E, Rice, G, Kasher, P, Lafontaine, D, Crow, Y & O'Keefe, R 2020, ' Analysis of U8 snoRNA Variants in Zebrafish Reveals how Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts ', American Journal of Human Genetics, vol. 106, no. 5, pp. 694-706 . https://doi.org/10.1016/j.ajhg.2020.04.003
Badrock, A P, Uggenti, C, Wacheul, L, Crilly, S, Jenkinson, E M, Rice, G I, Kasher, P R, Lafontaine, D L J, Crow, Y J & O'Keefe, R T 2020, ' Analysis of U8 snoRNA Variants in Zebrafish Reveals how Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts ', American Journal of Human Genetics, vol. 106, no. 5, pp. 694-706 . https://doi.org/10.1016/j.ajhg.2020.04.003
American journal of human genetics, 106 (5

How mutations in the non-coding U8 snoRNA cause the neurological disorder leukoencephalopathy with calcifications and cysts (LCC) is poorly understood. Here, we report the generation of a mutant U8 animal model for interrogating LCC-associated pathol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849cb23302137c98d55f60d6c34d5a35
https://pubmed.ncbi.nlm.nih.gov/32359472

Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

Autor: Gerrard, Dave T., Berry, Andrew A., Jennings, Rachel E., Birket, Matthew J., Zarrineh, Peyman, Garstang, Myles G., Withey, Sarah L., Short, Patrick, Jiménez-Gancedo, Sandra, Firbas, Panos, Donaldson, Ian J., Sharrocks, Andrew D., Piper Hanley, Karen, Hurles, Matthew E., Gómez-Skarmeta, José Luis, Bobola, Nicoletta, Hanley, Neil A.

Publikováno v: Nature Communications
Gerrard, D T, Berry, A, Jennings, R, Birket, M, Zarrineh, P, Garstang, M, Withey, S, Short, P, Jiménez-Ganced, S, Firbas, P N, Donaldson, I, Sharrocks, A, Piper Hanley, K, Hurles, M E, Gomez-Skarmeta, J L, Bobola, N & Hanley, N 2020, ' Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders ', Nature Communications, vol. 11, no. 1, 3920, pp. 3920 . https://doi.org/10.1038/s41467-020-17305-2
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname

© The Author(s) 2020.
How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f30b91a04248ce2af21ba27666f9fbb
http://hdl.handle.net/10261/226280

Persistent increase in ecto‑5'‑nucleotidase activity from encephala of adult zebrafish exposed to ethanol during early development

Autor: Julia Huppes Majolo, Luiza Reali Nazario, Stefani Altenhofen, Talita Carneiro Brandão Pereira, Aline Haab Lutte, Rosane Souza da Silva, Maurício Reis Bogo, Adilio da Silva Dadda

Publikováno v: Neurotoxicology and Teratology, 70, 60-66

Prenatal alcohol exposure causes alterations to the brain and can lead to numerous cognitive and behavioral outcomes. Long-lasting effects of early ethanol exposure have been registered in glutamatergic and dopaminergic systems. The purinergic system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9707674144c6dab07458f37fb62e79e
https://research.rug.nl/en/publications/98462a00-9b44-4a87-8f09-e517358645ed

TALE factors use two distinct functional modes to control an essential zebrafish gene expression program

Autor: Nicoletta Bobola, William Stanney, Franck Ladam, Ian J. Donaldson, Charles G. Sagerström, Ozge Yildiz

Publikováno v: eLife
eLife, Vol 7 (2018)
Ladam, F, Stanney, W, Donaldson, I, Yildiz, O, Bobola, N & Sagerström, C 2018, ' TALE factors use two distinct functional modes to control an essential zebrafish gene expression program ', eLife, vol. 7, e36144 . https://doi.org/10.7554/eLife.36144

TALE factors are broadly expressed embryonically and known to function in complexes with transcription factors (TFs) like Hox proteins at gastrula/segmentation stages, but it is unclear if such generally expressed factors act by the same mechanism th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4e4c1c53a529742b515f7133c6a5cf
http://europepmc.org/articles/PMC6023610