Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Zeba Wunderlich"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011567 (2023)
Innate immune priming increases an organism's survival of a second infection after an initial, non-lethal infection. We used Drosophila melanogaster and an insect-derived strain of Enterococcus faecalis to study transcriptional control of priming. In
Externí odkaz:
https://doaj.org/article/5ec1ad9529b3416fa1f4aa1c40ce45a6
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011071 (2023)
Enhancers are stretches of regulatory DNA that bind transcription factors (TFs) and regulate the expression of a target gene. Shadow enhancers are two or more enhancers that regulate the same target gene in space and time and are associated with most
Externí odkaz:
https://doaj.org/article/f681706b22b44780973026bf9dc8aa81
Autor:
Bryan A. Ramirez-Corona, Anna C. Love, Srikiran Chandrasekaran, Jennifer A. Prescher, Zeba Wunderlich
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105378- (2022)
Summary: The innate immune system is critical for infection survival. Drosophila melanogaster is a key model for understanding the evolution and dynamics of innate immunity. Current toolsets for fly infection studies are limited in throughput and, be
Externí odkaz:
https://doaj.org/article/79bafaa1675147bda5b79a15cfb33f6f
Autor:
Francheska López-Rivera, Olivia K. Foster Rhoades, Ben J. Vincent, Edward C. G. Pym, Meghan D. J. Bragdon, Javier Estrada, Angela H. DePace, Zeba Wunderlich
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 12, Pp 4473-4482 (2020)
Externí odkaz:
https://doaj.org/article/7877909398334da2832ed1d253415d15
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103034- (2021)
Summary: Transgenic reporters allow the measurement of regulatory DNA activity in vivo and consequently have long been useful tools for studying enhancers. Despite their utility, few studies have investigated the effects these reporters may have on t
Externí odkaz:
https://doaj.org/article/2350c307b4ab473a8d6248153f137acb
Autor:
Zeba Wunderlich, Charless C. Fowlkes, Kelly B. Eckenrode, Meghan D. J. Bragdon, Arash Abiri, Angela H. DePace
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2171-2182 (2019)
Complex spatiotemporal gene expression patterns direct the development of the fertilized egg into an adult animal. Comparisons across species show that, in spite of changes in the underlying regulatory DNA sequence, developmental programs can be main
Externí odkaz:
https://doaj.org/article/9a3bccc7564c43f1bb7f313ed4835c39
Publikováno v:
eLife, Vol 9 (2020)
Shadow enhancers, groups of seemingly redundant enhancers, are found in a wide range of organisms and are critical for robust developmental patterning. However, their mechanism of action is unknown. We hypothesized that shadow enhancers drive consist
Externí odkaz:
https://doaj.org/article/4db077763b75456d9893ed45cf12183b
Autor:
Md. Abul Hassan Samee, Tara Lydiard-Martin, Kelly M. Biette, Ben J. Vincent, Meghan D. Bragdon, Kelly B. Eckenrode, Zeba Wunderlich, Javier Estrada, Saurabh Sinha, Angela H. DePace
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 236-245 (2017)
Computational models of enhancer function generally assume that transcription factors (TFs) exert their regulatory effects independently, modeling an enhancer as a “bag of sites.” These models fail on endogenous loci that harbor multiple enhancer
Externí odkaz:
https://doaj.org/article/9483d46b30264d13827a992033d7aa7d
Autor:
Jeehae Park, Javier Estrada, Gemma Johnson, Ben J Vincent, Chiara Ricci-Tam, Meghan DJ Bragdon, Yekaterina Shulgina, Anna Cha, Zeba Wunderlich, Jeremy Gunawardena, Angela H DePace
Publikováno v:
eLife, Vol 8 (2019)
Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm e
Externí odkaz:
https://doaj.org/article/89490033d56044918068e1ebc5396b93
Autor:
Ben J Vincent, Max V Staller, Francheska Lopez-Rivera, Meghan D J Bragdon, Edward C G Pym, Kelly M Biette, Zeba Wunderlich, Timothy T Harden, Javier Estrada, Angela H DePace
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007644 (2018)
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its targ
Externí odkaz:
https://doaj.org/article/5083d378a6224632ac9d51e671b59a36