Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Zeba Sultana"'
Autor:
Jonas Engesser, Robin Khatri, Darius P. Schaub, Yu Zhao, Hans-Joachim Paust, Zeba Sultana, Nariaki Asada, Jan-Hendrik Riedel, Varshi Sivayoganathan, Anett Peters, Anna Kaffke, Saskia-Larissa Jauch-Speer, Thiago Goldbeck-Strieder, Victor G. Puelles, Ulrich O. Wenzel, Oliver M. Steinmetz, Elion Hoxha, Jan-Eric Turner, Hans-Willi Mittrücker, Thorsten Wiech, Tobias B. Huber, Stefan Bonn, Christian F. Krebs, Ulf Panzer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN r
Externí odkaz:
https://doaj.org/article/287d8b69dd7e4d95bc28f18d29e2859c
Autor:
Zeba Sultana, Mathurin Dorel, Bertram Klinger, Anja Sieber, Ilona Dunkel, Nils Blüthgen, Edda G Schulz
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 11, Pp n/a-n/a (2023)
Abstract For a short period during early development of mammalian embryos, both X chromosomes in females are active, before dosage compensation is ensured through X‐chromosome inactivation. In female mouse embryonic stem cells (mESCs), which carry
Externí odkaz:
https://doaj.org/article/5b44e3745a824717b6b7764ab828cf7a
Autor:
Zeba Sultana, Feda Azab, Taher Abbasi, Ravi Vij, Nicholas Potter, Anuj Tyagi, Shireen Vali, Pilar de la Puente, Abdel Kareem Azab, Mark A. Fiala, Barbara Muz, Jacob Paasch, Joseph Abraham
Publikováno v:
British Journal of Haematology. 165:89-101
The phosphatidylinositide 3-kinase (PI3K) pathway is activated and correlated with drug resistance in multiple myeloma (MM). In the present study we investigated the role of PI3KCA (PI3K-α) in the progression and drug resistance in MM. We showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c917ff2547dce94377ad0fdf1556b1b
https://doi.org/10.1111/bjh.12734
https://doi.org/10.1111/bjh.12734
Autor:
Janitha C Darlybai, Taher Abbasi, Ansu Kumar, Amitabha Mazumder, Aditi Aggarwal, Krithika Shetty, Neeraj Kumar Singh, Shweta Kapoor, Ashish Kumar Agrawal, Nicole A. Doudican, Zeba Sultana, Anay Talawdekar, Kabya Basu, Chandan Kumar, Anuj Tyagi, Shireen Vali
Publikováno v:
Journal of Cancer
Introduction Ursolic acid (UA) is a pentacyclic triterpene acid present in many plants, including apples, basil, cranberries, and rosemary. UA suppresses proliferation and induces apoptosis in a variety of tumor cells via inhibition of nuclear factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b04ed2ea4662e4f622d8b6f70d21f5
https://doi.org/10.7150/jca.7680
https://doi.org/10.7150/jca.7680
Autor:
Julie K. Andersen, Zeba Sultana, S. Sharada, Purushottam Sharma, M.M. Srinivas Bharath, Shireen Vali, Neetu Singh, Shankar J. Chinta, Jun Peng
Publikováno v:
Free Radical Biology and Medicine. 45:1290-1301
Dopaminergic neurodegeneration during Parkinson disease (PD) involves several pathways including proteasome inhibition, alpha-synuclein (alpha-syn) aggregation, mitochondrial dysfunction, and glutathione (GSH) depletion. We have utilized a systems bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d68a804ef0b1c7054931acb65615696
https://doi.org/10.1016/j.freeradbiomed.2008.08.002
https://doi.org/10.1016/j.freeradbiomed.2008.08.002
Autor:
Mary Ann Perle, Nicole A. Doudican, Zeba Sultana, Neeraj Kumar Singh, Ansu Kumar, Amitabha Mazumder, Ravi Vij, Kabya Basu, Mark A. Fiala, Shireen Vali, Deepak Anil Lala, Justin King, Prashant Ramachandran Nair, Krishna Kumar Tiwari, Anuj Tyagi, Taher Abbasi, Anay Talawdekar
Publikováno v:
Journal of Translational Medicine
Background The personalization of cancer treatments implies the reconsideration of a one-size-fits-all paradigm. This move has spawned increased use of next generation sequencing to understand mutations and copy number aberrations in cancer cells. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29dc30e2ef02346c467978dee0e3089
http://europepmc.org/articles/PMC4320499
http://europepmc.org/articles/PMC4320499
Autor:
H. Jiao, Zeba Sultana, Karima M. Al-Mansoori, Shireen Vali, Omar M. A. El-Agnaf, Mustafa T. Ardah, Francis Martin, Neeraj Kumar Singh, S. Usmani, Muchukunte Mukunda Srinivas Bharath, K.E. Paleologou
Publikováno v:
Neuroscience. 199
Protein aggregation is the major pathological hallmark seen in neurodegenerative disorders such as Parkinson's disease (PD). Alpha-synuclein (αS) is the main component of protein aggregates that form Lewy bodies (LBs) in PD and dementia with LBs. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3bb6a64318a0719dc1dbd99f2b2119
https://pubmed.ncbi.nlm.nih.gov/22056602
https://pubmed.ncbi.nlm.nih.gov/22056602
Autor:
Taher Abbasi, Kabya Basu, Neeraj Kumar Singh, Amitabha Mazumder, Ansu Kumar, Nicole A. Doudican, Zeba Sultana, Shireen Vali
Publikováno v:
Cancer Research. 75:5443-5443
Background: Given the genomic variability observed across multiple myeloma patients, treatment personalization becomes imperative. Personalization (N = 1) driven by actionable mutations alone is a step forward but has limitations. Holistically incorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93994ebb5851498e0bf6cd4588dbd32
https://doi.org/10.1158/1538-7445.am2015-5443
https://doi.org/10.1158/1538-7445.am2015-5443
Autor:
Taher Abbasi, Ansu Kumar, Mark A. Fiala, Justin King, Nicole A. Doudican, Zeba Sultana, Shireen Vali, Amitabha Mazumder, Ravi Vij, Kabya Basu, Neeraj Kumar Singh
Publikováno v:
Blood. 124:2232-2232
Background The epitome of cancer treatment personalization is N=1 segmentation where a custom therapy is designed for every patient. Because most cancer aberrations are not actionable mutations and tumors can have more than one actionable mutation, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13df33c2232bbd6c04dec0ce0c97189a
https://doi.org/10.1182/blood.v124.21.2232.2232
https://doi.org/10.1182/blood.v124.21.2232.2232
Autor:
Ansu Kumar, Annette Leon, Neeraj Kumar Singh, Amitabha Mazumder, Shweta Kapoor, Anuj Tyagi, Shireen Vali, Taher Abbasi, Nicole A. Doudican, Zeba Sultana
Publikováno v:
Cancer Research. 74:1706-1706
Background: The unique signature of a patient's tumor mandates the need to rationally design personalized therapies employing N=1 segmentation conceptually. By focusing on rationally designed personalized treatments, our strategy targets key pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70383e0e5bf9610a37bc310511a5dc87
https://doi.org/10.1158/1538-7445.am2014-1706
https://doi.org/10.1158/1538-7445.am2014-1706