Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ze-Yan Zhang"'
Autor:
Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qianghu Wang, Jie Yang, Aram S. Modrek, Hua Zhang, Aristotelis Tsirigos, Andrew Futreal, Giulio F. Draetta, Roel G. W. Verhaak, Erik P. Sulman
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-23 (2022)
Abstract Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed “CAPTURE”, a single-cell barcoding approach to comprehensive
Externí odkaz:
https://doaj.org/article/e91108592f504fbf93459cedf14bc51e
Autor:
Jie Yang, Qianghu Wang, Ze-Yan Zhang, Lihong Long, Ravesanker Ezhilarasan, Jerome M. Karp, Aristotelis Tsirigos, Matija Snuderl, Benedikt Wiestler, Wolfgang Wick, Yinsen Miao, Jason T. Huse, Erik P. Sulman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
No clinical assay currently exists to classify glioma tumours based on gene expression. Here, the authors develop a DNA methylation-based classifier, Unified Diagnostic Pipeline (UniD) that identifies genomic alterations and gene expression subtypes
Externí odkaz:
https://doaj.org/article/9402e29d8b264f52bcb0e2db7889bfee
Autor:
Shang-Ze Li, Ze-Yan Zhang, Jie Chen, Ming-You Dong, Xue-Hua Du, Jie Gao, Qi-Peng Shu, Chao Li, Xin-Yi Liang, Zhi-Hao Ding, Run-Lei Du, Junli Wang, Xiao-Dong Zhang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible for SRF regulation remain unclear
Externí odkaz:
https://doaj.org/article/f9f2d59e373445dfa84580f40a5d36f6
Autor:
Aram S. Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D. Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P. L. Bhat, Thanh-Thuy T. Le, Floris P. Barthel, Ming Tang, Jie Yang, Lihong Long, Joy Gumin, Frederick F. Lang, Roel G. W. Verhaak, Kenneth D. Aldape, Erik P. Sulman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them specifically are not well understood. We demonstrate that podoplanin (PDPN) expression is an indepe
Externí odkaz:
https://doaj.org/article/17361cb6986142ceaa84f9b6ee8f62af
Autor:
Yingwen Ding, Ze-Yan Zhang, Ravesanker Ezhilarasan, Aram S. Modrek, Jerome Karp, Erik P. Sulman
Publikováno v:
Cancer Research. 83:2819-2819
Glioblastoma multiforme (GBM) are the most malignant primary central nervous system tumors. The standard of care for newly diagnosed GBM patients includes surgery followed by combined radiation therapy (RT) and adjuvant temozolomide (TMZ) therapy. Ho
Autor:
Modrek, Aram S., Eskilsson, Eskil, Ezhilarasan, Ravesanker, Qianghu Wang, Goodman, Lindsey D., Yingwen Ding, Ze-Yan Zhang, Bhat, Krishna P. L., Le, Thanh-Thuy T., Barthel, Floris P., Ming Tang, Jie Yang, Lihong Long, Gumin, Joy, Lang, Frederick F., Verhaak, Roel G. W., Aldape, Kenneth D., Sulman, Erik P.
Publikováno v:
Frontiers in Oncology; 8/18/2022, Vol. 12, p1-14, 14p
Autor:
Veerakumar Balasubramaniyan, Ze-yan Zhang, John DeGroot, Erik P. Sulman, Yuji Piao, Sandeep Mittal, Jianwen Dong, Soon Young Park, Sabbir Khan, Emmanuel Martinez
Publikováno v:
Neuro Oncol
The median survival for patients with glioblastoma (GBM) is 12–15 months highlighting the need for better therapeutic strategies for this deadly disease. Genomic and epigenomic sequencing analysis at the single cell level have identified multiple g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1275070ecd32231590bc0c4db57e103
https://europepmc.org/articles/PMC6847454/
https://europepmc.org/articles/PMC6847454/
Autor:
Shang-Ze Li, Qi Zhang, Rongfu Tu, Zhe Zheng, Run-Lei Du, Ze-Yan Zhang, Yi-fan Jia, Xue-Min Song, Huan Du, Xiao-Dong Zhang
Publikováno v:
Cell Death Differ
The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) is one of the master regulators that control hundreds of genes containing antioxidant response elements (AREs). The NRF2-ARE pathway plays a complex role in colorectal cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c3992faac587161e04d03716823e72
https://europepmc.org/articles/PMC6889501/
https://europepmc.org/articles/PMC6889501/
Autor:
Shang-Ze Li, Qu-Ran Wu, Lu Gao, Wenbin Liu, Hui-Hui Zhang, Tong Liang, Xiao-Dong Zhang, Jun Gong, Na-Na Xing, Run-Lei Du, Ze-Yan Zhang
Publikováno v:
Molecular and Cellular Biology. 35:778-788
Interleukin-1β (IL-1β) is a key proinflammatory cytokine that initiates several signaling cascades, including those involving CCAAT/enhancer binding proteins (C/EBPs). The mechanism by which IL-1β propagates a signal that activates C/EBP has remai
Autor:
Xiao-Dong Zhang, Xingpeng Xiao, Jinyi Wu, Tong Su, Ze-Yan Zhang, Jianwei Ren, Jiongchang Zhu, Rihui Cao, Run-Lei Du
Publikováno v:
European journal of medicinal chemistry. 140
A series of novel water-soluble 4-quinolone-3-carboxamides was prepared and evaluated as antiproliferative agents. Preliminary results indicated that most compounds tested in this study showed potent antiproliferative potencies against human tumor ce