Výsledky vyhledávání - "Ze'ev A Ronai"

Akademický článek

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

Autor: Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J Kaufman, Ze'ev A Ronai

Publikováno v: PLoS Genetics, Vol 10, Iss 5, p e1004348 (2014)

The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). Yet, it is not known how UPR-signaling coordinates adaptation versus cell death. Previous studies suggested tha

Externí odkaz: https://doaj.org/article/6ddf1d2d0fe64df59b796ae086022ff2

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Akademický článek

β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors.

Autor: Luca Grumolato, Guizhong Liu, Tomomi Haremaki, Sathish Kumar Mungamuri, Phyllus Mong, Gal Akiri, Pablo Lopez-Bergami, Adriana Arita, Youssef Anouar, Marek Mlodzik, Ze'ev A Ronai, Joshua Brody, Daniel C Weinstein, Stuart A Aaronson

Publikováno v: PLoS Genetics, Vol 9, Iss 8, p e1003603 (2013)

The role of Wnt signaling in embryonic development and stem cell maintenance is well established and aberrations leading to the constitutive up-regulation of this pathway are frequent in several types of human cancers. Upon ligand-mediated activation

Externí odkaz: https://doaj.org/article/74e5edd7df0848589a031e25ce840979

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Akademický článek

The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.

Autor: Meifan Chen, Gustavo J Gutierrez, Ze'ev A Ronai

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35520 (2012)

The anaphase-promoting complex or cyclosome (APC/C) is a multi-subunit ubiquitin ligase that regulates exit from mitosis and G1 phase of the cell cycle. Although the regulation and function of APC/C(Cdh1) in the unperturbed cell cycle is well studied

Externí odkaz: https://doaj.org/article/1333fa9c2aae4ab8a14e4442859ecb38

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Akademický článek

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.

Autor: Ersheng Kuang, Cheryl Y M Okumura, Sharon Sheffy-Levin, Tal Varsano, Vincent Chih-Wen Shu, Jianfei Qi, Ingrid R Niesman, Huei-Jiun Yang, Carlos López-Otín, Wei Yuan Yang, John C Reed, Limor Broday, Victor Nizet, Ze'ev A Ronai

Publikováno v: PLoS Genetics, Vol 8, Iss 10, p e1003007 (2012)

Autophagy is the mechanism by which cytoplasmic components and organelles are degraded by the lysosomal machinery in response to diverse stimuli including nutrient deprivation, intracellular pathogens, and multiple forms of cellular stress. Here, we

Externí odkaz: https://doaj.org/article/8cd0cc7e2da7426d9f257e0e0de91174

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Akademický článek

A role for ATF2 in regulating MITF and melanoma development.

Autor: Meera Shah, Anindita Bhoumik, Vikas Goel, Antimone Dewing, Wolfgang Breitwieser, Harriet Kluger, Stan Krajewski, Maryla Krajewska, Jason Dehart, Eric Lau, David M Kallenberg, Hyeongnam Jeong, Alexey Eroshkin, Dorothy C Bennett, Lynda Chin, Marcus Bosenberg, Nic Jones, Ze'ev A Ronai

Publikováno v: PLoS Genetics, Vol 6, Iss 12, p e1001258 (2010)

The transcription factor ATF2 has been shown to attenuate melanoma susceptibility to apoptosis and to promote its ability to form tumors in xenograft models. To directly assess ATF2's role in melanoma development, we crossed a mouse melanoma model (N

Externí odkaz: https://doaj.org/article/22c8be667d5045afa6cddd3301a0049b

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