Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Zdzisław M. Szulc"'
Autor:
Maria Podbielska, Zdzisław M. Szulc, Ewa Kurowska, Edward L. Hogan, Jacek Bielawski, Alicja Bielawska, Narayan R. Bhat
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 11, Pp 2028-2039 (2016)
Th1 pro-inflammatory cytokines, i.e., TNF-α and IFN-γ, in combination are known to induce cell death in several cell types, including oligodendrocytes, but the mechanism of their synergistic cytotoxicity is unclear. Although ceramide (Cer) has been
Externí odkaz:
https://doaj.org/article/0cb7825e57444a58a6b77d7b412c5112
Autor:
Megan Sheridan, Nityananda Chowdhury, Bridgette Wellslager, Natalia Oleinik, Mohamed Faisal Kassir, Han G. Lee, Mindy Engevik, Yuri Peterson, Subramanya Pandruvada, Zdzislaw M. Szulc, Özlem Yilmaz, Besim Ogretmen
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109860- (2024)
Summary: Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P. gingivalis infection mediates therapeutic resistance via inhibiting let
Externí odkaz:
https://doaj.org/article/220745108259458d9a2aad4c63ed23d9
Autor:
Maria Podbielska, Zdzislaw M. Szulc, Toshio Ariga, Anna Pokryszko-Dragan, Wojciech Fortuna, Małgorzata Bilinska, Ryszard Podemski, Ewa Jaskiewicz, Ewa Kurowska, Robert K. Yu, Edward L. Hogan
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1464-1479 (2020)
Multiple sclerosis (MS) is a CNS disease characterized by immune-mediated demyelination and progressive axonal loss. MS-related CNS damage and its clinical course have two main phases: active and inactive/progressive. Reliable biomarkers are being so
Externí odkaz:
https://doaj.org/article/1a60c2df186d41a794a955403678fd2f
Autor:
Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and act
Externí odkaz:
https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e
Autor:
Qi Hou, Junfei Jin, Hui Zhou, Sergei A. Novgorodov, Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Yi-Te Hsu
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 278-288 (2011)
C6-pyridinium (d-erythro-2-N-[6′-(1′′-pyridinium)-hexanoyl]sphingosine bromide [LCL29]) is a cationic mitochondrion-targeting ceramide analog that promotes mitochondrial permeabilization and cancer cell death. In this study, we compared the bio
Externí odkaz:
https://doaj.org/article/273e6d08020446feb5a1621d0a08299c
Autor:
Samer El Bawab, Julnar Usta, Patrick Roddy, Zdzislaw M. Szulc, Alicja Bielawska, Yusuf A. Hannun
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 1, Pp 141-148 (2002)
In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of subst
Externí odkaz:
https://doaj.org/article/29977435aa38499db1faa476259b0c74