Výsledky vyhledávání - "Zdenek Vavrin"

Akademický článek

Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose

Autor: John B. Hibbs Jr., Zdenek Vavrin, James E. Cox

Publikováno v: Redox Biology, Vol 8, Iss C, Pp 271-284 (2016)

Complex metabolism is thought to occur exclusively in the crowded intracellular environment. Here we report that diluted enzymes from lysed human leukocytes produce extracellular energy. Our findings involve two pathways: the purine nucleotide catabo

Externí odkaz: https://doaj.org/article/b1b2ba89f4c64a1b807f12a4c654e7bc

Zobrazit plný text záznamu

Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose

Autor: James E. Cox, John B. Hibbs, Zdenek Vavrin

Publikováno v: Redox Biology, Vol 8, Iss C, Pp 271-284 (2016)
Redox Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97019a8ae08f6f9f4bdbae6ef7dbff9
http://www.sciencedirect.com/science/article/pii/S221323171630012X

Zobrazit plný text záznamu

Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells

Autor: Zdenek Vavrin, Marion L. Woods, John B. Hibbs, Jeanmarie Mayer

Publikováno v: Scopus-Elsevier

McCoy cells, murine-derived cells commonly used for propagation of chlamydiae, were found to be efficient producers of nitric oxide (NO) when primed with murine gamma interferon (IFN-gamma) and then exposed to the second signals provided by Escherich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb744d25325c1710bcd151bac2f8207
https://doi.org/10.1128/iai.61.2.491-497.1993

Zobrazit plný text záznamu

Nitric oxide production during murine Lyme disease: lack of involvement in host resistance or pathology

Autor: Janis J. Weis, Zdenek Vavrin, Ernst J. Eichwald, Kathleen Petri Seiler, John B. Hibbs

The murine model of Lyme disease was used to determine the role of inflammatory induced nitric oxide (NO) during infection by the spirochete Borrelia burgdorferi. The outer surface lipoproteins of B. burgdorferi are potent stimulators of inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91445d337e0893ea9c732dafd63f00b6
https://europepmc.org/articles/PMC173547/

Zobrazit plný text záznamu

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy

Autor: C. Kablitz, R. L. Menlove, Read R. Taintor, M. P. McMurry, R. L. Baranowski, Zdenek Vavrin, James P. Kushner, John B. Hibbs, John H. Ward, Christof Westenfelder

An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. High-dose interleukin-2 (IL-2) therapy is known to induce the same cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdb15f8586f42386c5e6ecc3421ec52
https://europepmc.org/articles/PMC442932/

Zobrazit plný text záznamu

Activated macrophage conditioned medium: identification of the soluble factors inducing cytotoxicity and the L-arginine dependent effector mechanism

Autor: Charles J. Parker, Read R. Taintor, Ina J. Amber, Zdenek Vavrin, Barbara B. Johnson, John B. Hibbs

Publikováno v: Journal of leukocyte biology. 49(6)

Conditioned medium (CM) from cultures of cytotoxic activated macrophages causes inhibition of mitochondrial respiration, DNA synthesis, and aconitase activity in murine EMT-6 mammary adenocarcinoma cells by an l-arginine dependent effector mechanism.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4d194fb2c712ba8a59a77d8e0902fa
https://pubmed.ncbi.nlm.nih.gov/1902865

Zobrazit plný text záznamu

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

Autor: Read R. Taintor, John B. Hibbs, Zdenek Vavrin

Publikováno v: Science. 235:473-476

Previous studies have shown that cytotoxic activated macrophages cause inhibition of DNA synthesis, of mitochondrial respiration, and of aconitase activity in tumor target cells. An L-arginine-dependent biochemical pathway synthesizing L-citrulline a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c2cfdc19aa7dc4868d15657746a6e1
https://doi.org/10.1126/science.2432665

Zobrazit plný text záznamu

SHORT COMMUNICATION: Cytokines Induce an L-Arginine-Dependent Effector System in Nonmacrophage Cells

Autor: Read R. Taintor, Zdenek Vavrin, Ina J. Amber, John B. Hibbs

Publikováno v: Journal of Leukocyte Biology. 44:58-65

Treatment of EMT-6 mammary adenocarcinoma cells with gamma interferon (rMuIFNγ) plus tumor necrosis factor (rMuTNFα) and/or interleukin-1 (rHuIL-1α) causes release of iron-55 label, inhibition of DNA replication, and inhibition of aconitase activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da7090bb4be332830147e68b46bb5cee
https://doi.org/10.1002/jlb.44.1.58

Zobrazit plný text záznamu

Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation

Autor: Harold A. Chapman, Zdenek Vavrin, O L Stone

Publikováno v: Journal of Clinical Investigation. 73:806-815

Fibrin deposition is prominent in the histopathology of a number of inflammatory lung diseases. Plasmin, activated locally in the lung, can degrade not only this fibrin but potentially structural proteins important to normal lung architecture. Becaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0053612cd3a1217d9259e42cf4cc711f
https://doi.org/10.1172/jci111275

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání