Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zdenek Skrott"'
Autor:
Tereza Buchtova, Zdenek Skrott, Katarina Chroma, Jiri Rehulka, Petr Dzubak, Marian Hajduch, David Lukac, Stefanos Arampatzis, Jiri Bartek, Martin Mistrik
Publikováno v:
Molecular Oncology, Vol 16, Iss 7, Pp 1541-1554 (2022)
Disulfiram (DSF), an established alcohol‐aversion drug, is a candidate for repurposing in cancer treatment. DSF’s antitumor activity is supported by preclinical studies, case reports, and small clinical trials; however, ongoing clinical trials of
Externí odkaz:
https://doaj.org/article/3191b1b97405485c86205c2179ad7bf2
Autor:
Katarina Chroma, Zdenek Skrott, Jan Gursky, Jaroslav Bacovsky, Pavel Moudry, Tereza Buchtova, Martin Mistrik, Jiri Bartek
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract Despite several approved therapeutic modalities, multiple myeloma (MM) remains an incurable blood malignancy and only a small fraction of patients achieves prolonged disease control. The common anti-MM treatment targets proteasome with speci
Externí odkaz:
https://doaj.org/article/3a153f215b3941189abf8b25abc8d0bc
Autor:
Martin Mistrik, Zdenek Skrott, Petr Muller, Ales Panacek, Lucie Hochvaldova, Katarina Chroma, Tereza Buchtova, Veronika Vandova, Libor Kvitek, Jiri Bartek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Existing methods for inflicting cellular heat shock are limited by the time delay in achieving the desired temperature and the spatial precision that can be achieved. Here the authors report a method to induce focused thermal protein damage using pla
Externí odkaz:
https://doaj.org/article/67d69097392d41a296cc051f0474624c
Autor:
Dusana Majera, Zdenek Skrott, Katarina Chroma, Joanna Maria Merchut-Maya, Martin Mistrik, Jiri Bartek
Publikováno v:
Cells, Vol 9, Iss 2, p 469 (2020)
Research on repurposing the old alcohol-aversion drug disulfiram (DSF) for cancer treatment has identified inhibition of NPL4, an adaptor of the p97/VCP segregase essential for turnover of proteins involved in multiple pathways, as an unsuspected can
Externí odkaz:
https://doaj.org/article/723530eee941401d91ee45362c782d89
Autor:
Dimitris C. Kanellis, Asimina Zisi, Zdenek Skrott, Bennie Lemmens, Jaime A. Espinoza, Martin Kosar, Andrea Björkman, Xuexin Li, Stefanos Arampatzis, Jirina Bartkova, Miguel Andújar-Sánchez, Oscar Fernandez-Capetillo, Martin Mistrik, Mikael S. Lindström, Jiri Bartek
Publikováno v:
Cell Death & Differentiation.
Drug repurposing is a versatile strategy to improve current therapies. Disulfiram has long been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its clinical value in oncology are ongoing. We have recently reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325a36b9b0cd268632e2140c12998faf
https://doi.org/10.1038/s41418-023-01167-4
https://doi.org/10.1038/s41418-023-01167-4
Publikováno v:
Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XX.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a97f7dbc9985a3d9c53a56e120e8e2
https://doi.org/10.1117/12.2646593
https://doi.org/10.1117/12.2646593
Publikováno v:
Cancer Research. 83:4814-4814
Due to malignant transformation, cancer cells are characterized by elevated levels of genotoxic, replication or proteotoxic stresses, which makes them vulnerable to various external conditions, including increased temperature. Thus, hyperthermia repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c1fd48861997821ea5f2bacf364298
https://doi.org/10.1158/1538-7445.am2023-4814
https://doi.org/10.1158/1538-7445.am2023-4814
Publikováno v:
International Journal of Molecular Sciences. 24:2885
Cannabidiol (CBD) is an easily accessible and affordable Marijuana (Cannabis sativa L.) plant derivative with an extensive history of medical use spanning thousands of years. Interest in the therapeutic potential of CBD has increased in recent years,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2190782b4ca22d89deba56e92303f0
https://doi.org/10.3390/ijms24032885
https://doi.org/10.3390/ijms24032885
Autor:
David Lukac, Katarina Chroma, Jiri Bartek, Marian Hajduch, Jiri Rehulka, Stefanos Arampatzis, Zdenek Skrott, Petr Dzubak, Martin Mistrik, Tereza Buchtova
Publikováno v:
Molecular oncology. 16(7)
Disulfiram (DSF), an established alcohol-aversion drug, is a candidate for repurposing in cancer treatment. DSF's antitumor activity is supported by preclinical studies, case reports, and small clinical trials; however, ongoing clinical trials of adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631b8e2b36e2ee157ff0f05aca6b67c3
https://pubmed.ncbi.nlm.nih.gov/34632694
https://pubmed.ncbi.nlm.nih.gov/34632694
Autor:
Martin Mistrik, Tereza Buchtova, Katarina Chroma, Marian Hajduch, Jiri Rehulka, Jiri Bartek, Petr Dzubak, Zdenek Skrott, Stefanos Arampatzis, David Lukac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf9407d91bc6ecad58e4e05c9233f76
https://doi.org/10.1002/1878-0261.13114/v2/response1
https://doi.org/10.1002/1878-0261.13114/v2/response1
