Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Zdenek Andrysik"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 p
Externí odkaz:
https://doaj.org/article/ba96d94410b24d0bac5244271212e7b7
Autor:
Maria M. Szwarc, Anna L. Guarnieri, Molishree Joshi, Huy N. Duc, Madison C. Laird, Ahwan Pandey, Santosh Khanal, Emily Dohm, Aimee K. Bui, Kelly D. Sullivan, Matthew D. Galbraith, Zdenek Andrysik, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112230- (2023)
Summary: Inactivation of the p53 tumor suppressor, either by mutations or through hyperactivation of repressors such as MDM2 and MDM4, is a hallmark of cancer. Although many inhibitors of the p53-MDM2/4 interaction have been developed, such as Nutlin
Externí odkaz:
https://doaj.org/article/d6d8dbe69f8949288e595955b15dcfa6
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating
Externí odkaz:
https://doaj.org/article/08311375eed848a4a71efdc960482a8f
Autor:
Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108407- (2020)
Summary: Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN) signaling and chronic inflammation, which could potentially be explained by the extra copy of four IFN receptor (IFNR) genes encoded on chromosome 21
Externí odkaz:
https://doaj.org/article/8fd7536ebdba4b9c98e33eeca1e00d4f
Autor:
Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3224-3236 (2018)
Summary: The transcriptional repressor ΔNp63α is a potent oncogene widely overexpressed in squamous cell carcinomas (SCCs) of diverse tissue origins, where it promotes malignant cell proliferation and survival. We report here the results of a genom
Externí odkaz:
https://doaj.org/article/60fb82783f564e16bde7d87fedbfa965
Autor:
Matthew D. Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A. Bonner, Amanda A. Hill, Kelly D. Sullivan, Joaquín M. Espinosa
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1495-1506 (2017)
Summary: Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues. Despite its importance in cancer development, our understanding of mechanisms driving this form of metabolic reprogramming is incomplete. We report her
Externí odkaz:
https://doaj.org/article/dc5a2aad688c43518f9bf36aa5059abd
Autor:
Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz, Jacob Gump, Paola Maycotte, Andrew Oberst, Douglas R. Green, Joaquín M. Espinosa, Andrew Thorburn
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 45-52 (2014)
Macroautophagy is thought to protect against apoptosis; however, underlying mechanisms are poorly understood. We examined how autophagy affects canonical death receptor-induced mitochondrial outer membrane permeabilization (MOMP) and apoptosis. MOMP
Externí odkaz:
https://doaj.org/article/5fb7353bdfb54e0ea13f4207e9e8414c
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1346-1354 (2013)
The p53 transcription factor participates in diverse cellular responses to stress, including cell-cycle arrest, apoptosis, senescence, and autophagy. The molecular mechanisms defining the ultimate outcome of p53 activation remain poorly characterized
Externí odkaz:
https://doaj.org/article/f1ca345cc362454aa31a57511d337e8e
Autor:
Mary Ann Allen, Zdenek Andrysik, Veronica L Dengler, Hestia S Mellert, Anna Guarnieri, Justin A Freeman, Kelly D Sullivan, Matthew D Galbraith, Xin Luo, W Lee Kraus, Robin D Dowell, Joaquin M Espinosa
Publikováno v:
eLife, Vol 3 (2014)
The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq). Shortly after MDM2 inhibition by Nutlin-3, low levels of p53 rapidly activ
Externí odkaz:
https://doaj.org/article/ed7fdb31069f44269a183d27ea24807e
Autor:
Roubina Tatavosian, Micah G. Donovan, Matthew D. Galbraith, Huy N. Duc, Maria M. Szwarc, Molishree U. Joshi, Amy Frieman, Ganna Bilousova, Yingqiong Cao, Keith P. Smith, Kunhua Song, Angela L. Rachubinski, Zdenek Andrysik, Joaquin M. Espinosa
Publikováno v:
Cell Death & Differentiation. 30:952-965
The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite decades of research, the mechanisms by which p53 impedes tumorigenesis across vastly different cellular c