Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zdeněk Hodný"'
Autor:
Alexandra Urbancokova, Terezie Hornofova, Josef Novak, Sarka Andrs Salajkova, Sona Stemberkova Hubackova, Alena Uvizl, Tereza Buchtova, Martin Mistrik, Brian McStay, Zdenek Hodny, Jiri Bartek, Pavla Vasicova
Publikováno v:
eLife, Vol 12 (2024)
PML, a multifunctional protein, is crucial for forming PML-nuclear bodies involved in stress responses. Under specific conditions, PML associates with nucleolar caps formed after RNA polymerase I (RNAPI) inhibition, leading to PML-nucleolar associati
Externí odkaz:
https://doaj.org/article/a1e5baec59f2483e9bfc86be8159da44
Autor:
Veronika Fedorova, Veronika Pospisilova, Tereza Vanova, Katerina Amruz Cerna, Pavel Abaffy, Jiri Sedmik, Jan Raska, Simona Vochyanova, Zuzana Matusova, Jana Houserova, Lukas Valihrach, Zdenek Hodny, Dasa Bohaciakova
Publikováno v:
Molecular Oncology, Vol 17, Iss 4, Pp 647-663 (2023)
It is currently challenging to adequately model the growth and migration of glioblastoma using two‐dimensional (2D) in vitro culture systems as they quickly lose the original, patient‐specific identity and heterogeneity. However, with the advent
Externí odkaz:
https://doaj.org/article/b304c5e41f08440b9da8a1c990ebbc79
Autor:
Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y. Alomar, Fernanda D. Botelho, Tanos C.C. Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115600- (2023)
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s br
Externí odkaz:
https://doaj.org/article/44e7104b724844208bfcb788fd0917db
Autor:
Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Marek Bajda, Milan Reinis, Romana Mikyskova, Ondrej Novotny, Rudolf Andrys, Adam Skarka, Pavla Vasicova, Josef Novak, Martin Valis, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties. Therefore, we have dec
Externí odkaz:
https://doaj.org/article/2138141c119d4080852852773bb5684e
Autor:
Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication str
Externí odkaz:
https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa2
Autor:
Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://doaj.org/article/cfac0c0e4320428ab38cfae14e7c28f8
Autor:
Barbora Salovska, Hongwen Zhu, Tejas Gandhi, Max Frank, Wenxue Li, George Rosenberger, Chongde Wu, Pierre‐Luc Germain, Hu Zhou, Zdenek Hodny, Lukas Reiter, Yansheng Liu
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 3, Pp 1-19 (2020)
Abstract Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function. To thoroughly assess the role of protein post‐translational turnover, we devised a strateg
Externí odkaz:
https://doaj.org/article/7eb9b1cb88724f28b0e02d5b8de1d4d0
Autor:
Barbora Salovska, Alexandra Kondelova, Kristyna Pimkova, Zuzana Liblova, Miroslav Pribyl, Ivo Fabrik, Jiri Bartek, Marie Vajrychova, Zdenek Hodny
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102212- (2022)
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been re
Externí odkaz:
https://doaj.org/article/684d6ac1987a4935b8941c9e82074986
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 11, p e1389 (2011)
Latent toxoplasmosis, a lifelong infection with the protozoan Toxoplasma gondii, has cumulative effects on the behaviour of hosts, including humans. The most impressive effect of toxoplasmosis is the "fatal attraction phenomenon," the conversion of i
Externí odkaz:
https://doaj.org/article/1c1b942e480a47adb864d87131e80dfc
Publikováno v:
International Journal of Oncology
Cellular senescence is the process of the permanent proliferative arrest of cells in response to various inducers. It is accompanied by typical morphological changes, in addition to the secretion of bioactive molecules, including proinflammatory cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79db5e2b2acf288f046ebc3e10e8374
https://doi.org/10.3892/ijo.2018.4553
https://doi.org/10.3892/ijo.2018.4553