Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zdeněk Grof"'
Publikováno v:
Powder Technology. 386:505-518
Wurster fluid bed coating is an effective way of manufacturing pharmaceutical pellets requiring specific characteristics such as high drug loading or enteric protection. The optimization of coating process can be demanding because it necessitates man
Publikováno v:
Powder Technology. 377:257-268
The design of pharmaceutical tablets involves the determination of formulation parameters that define the tablet composition and internal microstructure. These parameters must be chosen so that the release of an active pharmaceutical ingredient (API)
Autor:
P. Zamostny, Vera Penkavova, Marek Schöngut, Zdeněk Grof, Miroslav Puncochar, Marek C. Ruzicka, Lukáš Kulaviak, Frantisek Stepanek
Publikováno v:
Powder Technology. 342:887-898
Granular particles of anisometric shape are common in many technologies and the knowledge of their compression response is needed for their handling, storage, transport and flow. Despite its importance, a little attention has been paid to this proble
Autor:
Josef Beranek, Matěj Novák, Adam Waněk, Tereza Boleslavská, Aleš Zadražil, Zdeněk Grof, Pavel Kovačík, František Štěpánek
Publikováno v:
AAPS PharmSciTech. 19:3414-3424
The problem of designing tablet geometry and its internal structure that results into a specified release profile of the drug during dissolution was considered. A solution method based on parametric programming, inspired by CAD (computer-aided design
Autor:
Zdeněk Grof, František Štěpánek
Publikováno v:
Computers & Chemical Engineering. 154:107492
A multi-material 3D printing offers nearly endless possibilities for the spatial arrangement of individual materials within the object being printed. In the case of pharmaceutical tablets, the spatial arrangement of individual material domains contai
Autor:
Zdeněk Grof, František Štěpánek
Publikováno v:
Advanced Powder Technology. 27:1093-1100
Understanding the relationship between the applied stress and the behaviour of packings of breakable granular particles is required in many chemical engineering applications. A pharmaceutical tablet is an example where a composite packing (a packing
Publikováno v:
International Journal of Pharmaceutics. 500:136-143
The rate of drug release from polymer matrix-based sustained release formulations is often controlled by the thickness of a gel layer that forms upon contact with dissolution medium. The effect of formulation parameters on the kinetics of elementary
Using a pharmaceutical formulation, granule batches were produced at a range of granulator volumes from 0.5 L to 400 L and process conditions, characterised by the Froude number in the range from Fr = 0.26 to Fr = 1.63. The mean values and the standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed39f9434c04f5066ac34171d1aded00
http://hdl.handle.net/10044/1/60140
http://hdl.handle.net/10044/1/60140
Publikováno v:
Journal of Colloid and Interface Science. 319:182-192
The strength of capillary bridges in randomly packed granular media was analyzed by means of computer simulations. A novel simulation method, based on the tracking of moving interfaces, has been implemented and used for determining the equilibrium sh
Publikováno v:
Granular Matter. 10:93-103
A numerical method for the simulation of spatially evolving liquid–vapour interfaces in arbitrary two dimensional granular media is presented. Solid- and liquid-phase objects are described by polynomials whose edges evolve according to surface tens