Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Zbynek Kozmik"'
Autor:
Anna Markos, Jan Kubovciak, Simona Mikula Mrstakova, Anna Zitova, Jan Paces, Simona Machacova, Zbynek Kozmik-Jr, Zbynek Kozmik, Iryna Kozmikova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract To shed light on the enigmatic origin of the vertebrate head, our study employs an integrated approach that combines single-cell transcriptomics, perturbations in signaling pathways, and cis-regulatory analysis in amphioxus. As a representat
Externí odkaz:
https://doaj.org/article/fddd25ac5d8b484b8335ef8f7cf02273
Autor:
Simona Mikula Mrstakova, Zbynek Kozmik
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Landmark discovery of eye defects caused by Pax6 gene mutations in humans, rodents, and even fruit flies combined with Pax6 gene expression studies in various phyla, led to the master control gene hypothesis postulating that the gene is required almo
Externí odkaz:
https://doaj.org/article/37029815e67d4dbabf8316fa7d351780
Autor:
Zbynek Kozmik, Iryna Kozmikova
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The Pax6 gene is essential for eye and brain development across various animal species. Here, we investigate the function of Pax6 in the development of the anterior central nervous system (CNS) of the invertebrate chordate amphioxus using CRISPR/Cas9
Externí odkaz:
https://doaj.org/article/e84f441e9ad54488acdadf46a7f28032
Autor:
Katerina Kvapilova, Pavol Misenko, Jan Radvanszky, Ondrej Brzon, Jaroslav Budis, Juraj Gazdarica, Ondrej Pos, Marie Korabecna, Martin Kasny, Tomas Szemes, Petr Kvapil, Jan Paces, Zbynek Kozmik
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Whole exome sequencing (WES) and whole genome sequencing (WGS) have become standard methods in human clinical diagnostics as well as in population genomics (POPGEN). Blood-derived genomic DNA (gDNA) is routinely used in the clinic
Externí odkaz:
https://doaj.org/article/a0a7b7e5449b4f6383ccc83c0d0fa3f4
Autor:
Cassie L. Kemmler, Jana Smolikova, Hannah R. Moran, Brandon J. Mannion, Dunja Knapp, Fabian Lim, Anna Czarkwiani, Viviana Hermosilla Aguayo, Vincent Rapp, Olivia E. Fitch, Seraina Bötschi, Licia Selleri, Emma Farley, Ingo Braasch, Maximina Yun, Axel Visel, Marco Osterwalder, Christian Mosimann, Zbynek Kozmik, Alexa Burger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression
Externí odkaz:
https://doaj.org/article/8918433ad9dc464ebd1fe886936070f5
Autor:
Andrea Kuzelova, Naoko Dupacova, Barbora Antosova, Sweetu Susan Sunny, Zbynek Kozmik, Jan Paces, Arthur I. Skoultchi, Tomas Stopka
Publikováno v:
Cells, Vol 12, Iss 7, p 1035 (2023)
Chromatin remodeling complexes are required for many distinct nuclear processes such as transcription, DNA replication, and DNA repair. However, the contribution of these complexes to the development of complex tissues within an organism is poorly ch
Externí odkaz:
https://doaj.org/article/13534090a80743e2a479128598f42d17
Autor:
Soyeon Lim, You-Joung Kim, Sooyeon Park, Ji-heon Choi, Young Hoon Sung, Katsuhiko Nishimori, Zbynek Kozmik, Han-Woong Lee, Jin Woo Kim
Publikováno v:
eLife, Vol 10 (2021)
Retinal progenitor cells (RPCs) divide in limited numbers to generate the cells comprising vertebrate retina. The molecular mechanism that leads RPC to the division limit, however, remains elusive. Here, we find that the hyperactivation of mechanisti
Externí odkaz:
https://doaj.org/article/a03459b91f7d4c9f9755e27b55ef3cbb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cephalochordates (amphioxi or lancelets) are representatives of the most basally divergent group of the chordate phylum. Studies of amphioxus development and anatomy hence provide a key insight into vertebrate evolution. More widespread use of amphio
Externí odkaz:
https://doaj.org/article/90fb81a837ea4a799c5e73c2e998cd8f
Autor:
Karin D. Prummel, Christopher Hess, Susan Nieuwenhuize, Hugo J. Parker, Katherine W. Rogers, Iryna Kozmikova, Claudia Racioppi, Eline C. Brombacher, Anna Czarkwiani, Dunja Knapp, Sibylle Burger, Elena Chiavacci, Gopi Shah, Alexa Burger, Jan Huisken, Maximina H. Yun, Lionel Christiaen, Zbynek Kozmik, Patrick Müller, Marianne Bronner, Robb Krumlauf, Christian Mosimann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Numerous tissues are derived from the lateral plate mesoderm (LPM) but how this is specified is unclear. Here, the authors identify a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corr
Externí odkaz:
https://doaj.org/article/cfe6d2cea11f4fa1bf72c26475a34643
Autor:
Jan Kriska, Lucie Janeckova, Denisa Kirdajova, Pavel Honsa, Tomas Knotek, David Dzamba, Denisa Kolenicova, Olena Butenko, Martina Vojtechova, Martin Capek, Zbynek Kozmik, Makoto Mark Taketo, Vladimir Korinek, Miroslava Anderova
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Modulating endogenous regenerative processes may represent a suitable treatment for central nervous system (CNS) injuries, such as stroke or trauma. Neural stem/progenitor cells (NS/PCs), which naturally reside in the subventricular zone (SVZ) of the
Externí odkaz:
https://doaj.org/article/abcd8bb230064c7b80ad86ff6baa7608