Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Zbynek Heger"'
Autor:
Xueqin Huang, Eugenie Nepovimova, Vojtech Adam, Ladislav Sivak, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-26 (2024)
Abstract Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matrix metalloproteinase 9, within th
Externí odkaz:
https://doaj.org/article/62a2336fe2ad43b0b5b81b2a4d4bf541
Autor:
Miguel Angel Merlos Rodrigo, Hana Michalkova, Ana Maria Jimenez Jimenez, Frantisek Petrlak, Tomas Do, Ladislav Sivak, Yazan Haddad, Petra Kubickova, Vivian de los Rios, J. Ignacio Casal, Marina Serrano-Macia, Teresa C. Delgado, Loreto Boix, Jordi Bruix, Maria L. Martinez Chantar, Vojtech Adam, Zbynek Heger
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background & aims Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular carcinoma (HCC) cell
Externí odkaz:
https://doaj.org/article/7a0c75ad3012498a9f15fd7e736949c9
Autor:
Huaqing Jing, Yingzi Ren, Yue Zhou, Min Xu, Sona Krizkova, Zbynek Heger, Qiang Lu, Siyu Wang, Xiaoyang Liang, Vojtech Adam, Nan Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 5030-5047 (2023)
Liver fibrosis is a reversible pathological process caused by chronic liver damage and a major risk factor for hepatocellular carcinoma (HCC). Hepatic stellate cell (HSC) activation is considered the main target for liver fibrosis therapy. However, t
Externí odkaz:
https://doaj.org/article/333514efeab44f278703ef2cb243ae19
Autor:
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
AbstractPhosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberra
Externí odkaz:
https://doaj.org/article/2625c42c0d07439f92419713efaf92ad
Autor:
Eliska Prchalova, Martina Sukupova, David Malinak, Rudolf Andrys, Ladislav Sivak, Vladimir Pekarik, Adam Skarka, Jana Svobodova, Lukas Prchal, Lukas Fresser, Zbynek Heger, Kamil Musilek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115490- (2023)
The BODIPY-labelled oxime reactivator was prepared and used to study its biodistribution into central nervous system. The newly synthesized oxime was found to be weak inhibitor of acetylcholinesterase and strong inhibitor of butyrylcholinesterase. It
Externí odkaz:
https://doaj.org/article/e1552502a55f468193830aae36c102b1
Autor:
Hana Stepankova, Hana Michalkova, Zbynek Splichal, Lukas Richtera, Pavel Svec, Tomas Vaculovic, Jan Pribyl, Martin Kormunda, Simona Rex, Vojtech Adam, Zbynek Heger
Publikováno v:
Bioactive Materials, Vol 20, Iss , Pp 489-500 (2023)
Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nanoscaled materials, the relation between the size/morphology of nanoparticles with their biological activity remains not well understood. Therefor
Externí odkaz:
https://doaj.org/article/e6e9da90c26847df825914ccdd83765d
Autor:
Haoyu Gao, Eugenie Nepovimova, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca, Vojtech Adam
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106841- (2023)
Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer’s disease. The underlying me
Externí odkaz:
https://doaj.org/article/4000c7c7e6154523be784fecf503a04e
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have demonstrated that hypo
Externí odkaz:
https://doaj.org/article/59d2e4ea25f34731b6ab70e139099ec8
Autor:
Katerina Mitrevska, Miguel Angel Merlos Rodrigo, Natalia Cernei, Hana Michalkova, Zbynek Splichal, David Hynek, Ondrej Zitka, Zbynek Heger, Pavel Kopel, Vojtech Adam, Vedran Milosavljevic
Publikováno v:
Materials Today Bio, Vol 19, Iss , Pp 100570- (2023)
The combination of in ovo and ex ovo chorioallantoic membrane (CAM) assay provides an excellent platform which extends its relevance in studying carcinogenesis to the field of screening of anticancer activity of platinum nanoparticles (PtNPs) and fur
Externí odkaz:
https://doaj.org/article/47d5ea2b873e41f8a37cfe70229958c8
Autor:
Melanie Schürz, Joachim Danmayr, Maria Jaritsch, Eva Klinglmayr, Heloisa Melo Benirschke, Cristian‐Tudor Matea, Patrick Zimmerebner, Jakob Rauter, Martin Wolf, Fausto Gueths Gomes, Zdenek Kratochvil, Zbynek Heger, Andrew Miller, Thomas Heuser, Vesna Stanojlovic, Jana Kiefer, Tanja Plank, Litty Johnson, Martin Himly, Constantin Blöchl, Christian G. Huber, Martin Hintersteiner, Nicole Meisner‐Kober
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 12, Pp n/a-n/a (2022)
Abstract Extracellular vesicle (EV) research increasingly demands for quantitative characterisation at the single vesicle level to address heterogeneity and complexity of EV subpopulations. Emerging, commercialised technologies for single EV analysis
Externí odkaz:
https://doaj.org/article/bc490fa820b5407eba1c66b48d2d0011