Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Zbyněk Heger"'
Autor:
Ganesh Selvaraj Duraisamy, Eunji Jo, Ivana Huvarová, Kyu-Ho P. Park, Zbyněk Heger, Vojtěch Adam, Daniel Růžek, Marc P. Windisch, Andrew D. Miller
Publikováno v:
Heliyon, Vol 8, Iss 9, Pp e10465- (2022)
Ginsenosides are a class of natural steroid glycosides and triterpene saponins found in Panax ginseng. After screening of a commercial ginsenoside compound library for low cellular cytotoxicity and the ability to mediate efficient reductions in hepat
Externí odkaz:
https://doaj.org/article/a8de4d1d5ad84c698c444ee4e38e4f30
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112391- (2022)
Lenvatinib, a small molecule tyrosine kinase inhibitor (TKI), exhibits good inhibitory effect in several types of carcinomas. Specifically, it is the most effective TKI used for treatment of thyroid cancer. To extend pharmacokinetics data on this ant
Externí odkaz:
https://doaj.org/article/2f244a7545cb4a5faf7f44487ac55988
Autor:
Kateřina Jáklová, Tereza Feglarová, Simona Rex, Zbyněk Heger, Tomáš Eckschlager, Jan Hraběta, Petr Hodek, Matúš Kolárik, Radek Indra
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4250 (2021)
A tyrosine kinase inhibitor, vandetanib (Van), is an anticancer drug affecting the signaling of VEGFR, EGFR and RET protooncogenes. Van is primarily used for the treatment of advanced or metastatic medullary thyroid cancer; however, its usage is sign
Externí odkaz:
https://doaj.org/article/396c504b67bd4c449cfa0abb83b41c12
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 547 (2020)
Herein, the in vitro metabolism of tyrosine kinase inhibitor cabozantinib, the drug used for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma, was studied using hepatic microsomal samples of different human donor
Externí odkaz:
https://doaj.org/article/a49d55891bc547c19c2ebc52e3eb3fd4
Autor:
Jan Hraběta, Marie Belhajová, Hana Šubrtová, Miguel Angel Merlos Rodrigo, Zbyněk Heger, Tomáš Eckschlager
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4392 (2020)
Resistance to chemotherapeutics and targeted drugs is one of the main problems in successful cancer therapy. Various mechanisms have been identified to contribute to drug resistance. One of those mechanisms is lysosome-mediated drug resistance. Lysos
Externí odkaz:
https://doaj.org/article/2a64c230c017427d8d42287fa6476bfb
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling.
Externí odkaz:
https://doaj.org/article/96ba63b125104fb8bb0de0044473192a
Autor:
Radek Indra, Petr Pompach, Václav Martínek, Paulína Takácsová, Katarína Vavrová, Zbyněk Heger, Vojtěch Adam, Tomáš Eckschlager, Kateřina Kopečková, Volker Manfred Arlt, Marie Stiborová
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3392 (2019)
The metabolism of vandetanib, a tyrosine kinase inhibitor used for treatment of symptomatic/progressive medullary thyroid cancer, was studied using human hepatic microsomes, recombinant cytochromes P450 (CYPs) and flavin-containing monooxygenases (FM
Externí odkaz:
https://doaj.org/article/83936630d3544288aeea09a012d49661
Autor:
Avitabile, Marianna, Bonfiglio, Ferdinando, Aievola, Vincenzo, Cantalupo, Sueva, Maiorino, Teresa, Lasorsa, Vito Alessandro, Domenicotti, Cinzia, Marengo, Barbara, Zbyněk, Heger, Vojtěch, Adam, Iolascon, Achille, Capasso, Mario
Publikováno v:
In Computational and Structural Biotechnology Journal 2022 20:4437-4445
Autor:
Xueqin Huang, Eugenie Nepovimova, Vojtech Adam, Ladislav Sivak, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-26 (2024)
Abstract Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matrix metalloproteinase 9, within th
Externí odkaz:
https://doaj.org/article/62a2336fe2ad43b0b5b81b2a4d4bf541
Autor:
Haoyu Gao, Eugenie Nepovimova, Vojtech Adam, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Aging is generally regarded as an irreversible process, and its intricate relationship with the immune system has garnered significant attention due to its profound implications for the health and well-being of the aging population. As people age, a
Externí odkaz:
https://doaj.org/article/6d9bfa57f8f34d55949417fabec923a8