Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Zbigniew Zaslona"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9782 (2024)
Arginases are key enzymes that hydrolyze L-arginine to urea and L-ornithine in the urea cycle. The two arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), regulate the proliferation of cancer cells, migration, and apoptosis; affect immunosupp
Externí odkaz:
https://doaj.org/article/f55d7a71b0b640678ba32335c28fb305
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 513 (2024)
Asthma has reached epidemic levels, yet progress in developing specific therapies is slow. One of the main reasons for this is the fact that asthma is an umbrella term for various distinct subsets. Due to its high heterogeneity, it is difficult to es
Externí odkaz:
https://doaj.org/article/acaab72d2c644ed1a4e5a0d66f49609f
Autor:
Caroline E. Sutton, Conor M. Finlay, Mathilde Raverdeau, James O. Early, Joseph DeCourcey, Zbigniew Zaslona, Luke A. J. O’Neill, Kingston H. G. Mills, Annie M. Curtis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Circadian controls of immune responses by the molecular clock have been reported, but the underlying mechanisms are unclear. Here the authors show that the master circadian gene, Bmal1, is essential for modulating the homeostasis of myeloid cells to
Externí odkaz:
https://doaj.org/article/4eaabe1ffd9242d6a2d583bbb9b1dc73
Autor:
Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke A.J. O’Neill
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 151-161.e5 (2019)
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyropto
Externí odkaz:
https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785
Autor:
Bartlomiej Borek, Julita Nowicka, Anna Gzik, Marek Dziegielewski, Karol Jedrzejczak, Joanna Brzezinska, Marcin Grzybowski, Paulina Stanczak, Paulina Pomper, Agnieszka Zagozdzon, Tomasz Rejczak, Krzysztof Matyszewski, Adam Golebiowski, Jacek Olczak, Kamil Lisiecki, Magdalena Tyszkiewicz, Magdalena Kania, Sylwia Piasecka, Anna Cabaj, Paulina Dera, Krzysztof Mulewski, Jacek Chrzanowski, Damian Kusmirek, Elzbieta Sobolewska, Marta Magdycz, Lukasz Mucha, Marek Masnyk, Jakub Golab, Marcin Nowotny, Elzbieta Nowak, Agnieszka Napiorkowska-Gromadzka, Stanislaw Pikul, Radoslaw Jazwiec, Karolina Dzwonek, Pawel Dobrzanski, Michael Meyring, Krzysztof Skowronek, Piotr Iwanowski, Zbigniew Zaslona, Roman Blaszczyk
Publikováno v:
Molecular Cancer Therapeutics.
Pharmacological inhibition of the controlling immunity pathway enzymes arginases 1 and 2 (ARG1 and ARG2) is a promising strategy for cancer immunotherapy. Here, we report the discovery and development of OATD-02, an orally bioavailable, potent argina
Autor:
Derek P. Nolan, Zbigniew Zaslona, Luke A. J. O'Neill, Anne F. McGettrick, Victoria J. Tyrrell, Valerie B. O'Donnell, Sarah E. Corcoran, Ciana Diskin
Publikováno v:
The Journal of Immunology. 207:2551-2560
The protozoan parasite Trypanosoma brucei is the causative agent of the neglected tropical disease human African trypanosomiasis, otherwise known as sleeping sickness. Trypanosomes have evolved many immune-evasion mechanisms to facilitate their own s
Autor:
James J. Moon, Zbigniew Zaslona, Joseph Bazzill, Loka R. Penke, Yvonne J. Huang, Christina Draijer, Marc Peters-Golden, Njira L Lugogo, Jennifer M. Speth
Publikováno v:
FASEB J
Resident alveolar macrophages (AMs) suppress allergic inflammation in murine asthma models. Previously we reported that resident AMs can blunt inflammatory signaling in alveolar epithelial cells (ECs) by transcellular delivery of suppressor of cytoki
Autor:
Alessia Zotta, Sarah E. Corcoran, Ciana Diskin, Victoria J. Tyrrell, Zbigniew Zaslona, Valerie B. O'Donnell, Luke A. J. O'Neill
Publikováno v:
J. Immunol
PGs are important proinflammatory lipid mediators, the significance of which is highlighted by the widespread and efficacious use of nonsteroidal anti-inflammatory drugs in the treatment of inflammation. 4-Octyl itaconate (4-OI), a derivative of the
Autor:
Daniel R. Goldstein, Jennifer M. Speth, Peter Mancuso, Christine M. Freeman, Judy Chen, Christina Draijer, Loka R. Penke, Jeffrey L. Curtis, Zbigniew Zaslona, Marc Peters-Golden
Publikováno v:
Life Science Alliance
Dysregulation of self-renewal contributes to alterations in alveolar macrophages (AMs). In this study, Penke et al identify PGE2 as a suppressor of AM proliferation, whose divergent bioavailability in aged and cigarette smoke-exposed mice could expla
Autor:
Marc Peters-Golden, Zbigniew Zaslona, Christina Draijer, Jennifer M. Speth, Loka R. Penke, Joseph Bazzill, James J. Moon
Publikováno v:
A31. ASTHMA TRANSLATIONAL STUDIES.